US 9969686B2
· Tang et al.
· 2018
[cited by applicant]
US 20090263339A1
· Kyono et al.
· 2009
[cited by applicant]
US 20100324109A1
· Saurat
· 2010
[cited by applicant]
US 20190337927A1
· Einziger et al.
· 2019
[cited by applicant]
US 20190381004A1
· Einziger et al.
· 2019
[cited by applicant]
US 20200276100A1
· Einziger et al.
· 2020
[cited by applicant]
CN 106916171A
· 2017
[cited by applicant]
CN 106916171B
· 2019
[cited by applicant]
KR 20160128764A
· 2016
[cited by applicant]
WO WO0236561A1
· 2002
[cited by applicant]
WO 2014143125A1
· 2014
[cited by applicant]
WO WO2017156424A1
· 2017
[cited by examiner]
WO 2019200232A1
· 2019
[cited by applicant]
WO 2020041663A1
· 2020
[cited by applicant]
Bergman, et al., “Synthesis of indolocarbazole quinones; potent aryl hydrocarbon receptor ligands”, Tetrahedron 2002, 58 (7), pp. 1443-1452. (Year: 2002).
[cited by applicant]
Berridge, et al., (1996). The Biochemical and Cellular Basis of Cell Proliferation Assays That Use Tetrazolium Salts. Biochemica; 4:14-19.
[cited by applicant]
Black, et al., (1985). Athymic Nude Mice and Human Skin Grafting. In: Maibach, et al. (eds.). Models in Dermatology, vol. 1. Karger, Basel; 228-39.
[cited by applicant]
Boudreaul T, Pierre-Luc T. et al (2010). Synthesis and characterization of soluble indolo[3,2-b]carbazole derivatives for organic field-effect transistors, Organic Electronics 11(10): 1649-1659.
[cited by applicant]
Colombo, Francisca et al (2008). Three-component indium-mediated domino allylation of 1 H-indole-3-carbaldehyde with electron-rich (hetero)arenes: highly efficient access to variously functionalized indolylbutenes, Euro…
[cited by applicant]
Costin, G.-E, Raabe, R, (2013). Optimized in Vitro Pigmentation Screening Assay Using a Reconstructed Three Dimensional Human Skin Model. Rom. J. Biochem. 50(1); 15-27.
[cited by applicant]
Donato, et al., (1993). A Microassay for Measuring Cytochrome P450IA1 and P450IIB1 Activities in Intact Human and Rat Hepatocytes Cultured on 96-Well Plates. Anal Biochem; 213(1): 29-33.
[cited by applicant]
Elmore, (2007). Apoptosis: A Review of Programmed Cell Death. Toxicologic Pathology; 35:495-516.
[cited by applicant]
Fitzpatrick, et al., (1988). The Validity and Practicality of Sun-Reactive Skin Types I Though VI. Arch Dermatol; 124 (6):869-871.
[cited by applicant]
Gaitanis, et al., (2013). Skin Diseases Associated with Malassezia Yeasts: Facts and Controversies. Clinics in Dermatology; 31 :455-463.
[cited by applicant]
Gambichler, et al. (2007). Quantification of Ultraviolet Protective Effects of Pityriacitrin in Humans. Archives of Dermatological Research; 299(10):517-520.
[cited by applicant]
Gueho, et al., (1996). The Genus
[cited by applicant]
He, et al., “Substrate-Controlled Regioselective Arylations of 2-Indolylmethanols with Indoles: Synthesis of Bis(indolyl)methane and 3,3′-Bisindole Derivatives”, J. Org. Chem. 2017, 82, pp. 2462-2471. (Year: 2017).
[cited by applicant]
Karchner, et al, (1999). Identification and Functional Characterization of Two Highly Divergent Aryl Hydrocarbon Receptors (AHR1 and AHR2) in the Teleost Fundulus Heteroclitus. The Journal of Biological Chemistry; 274 (…
[cited by applicant]
Kramer, et at, (2005). Malassezin, A Novel Analyst of the Aryl Hydrocarbon Receptor From the Yeast Malassezia furfur, Induces Apoptosis in Primary Human Melanocytes. ChemBioChem; 6:860-5.
[cited by applicant]
Lee, et al., (2013). Comparison of Gene Expression Profiles Between Keratinocytes, Melanocytes and Fibroblasts. Ann Dermatol.; 25(1):36-45.
[cited by applicant]
Liang, L., T. Fan, T. Huang, C. Yan, M. Xu and S. Liu, “A biomimetic method to synthesise indolo[3,2-a]carbazoles”, Tetrahedron Letters 56 (2015), pp. 434-436. (Year: 2015).
[cited by applicant]
Lin, Shu-Chen et al (1998). Indole-Carbonyl Coupling Reactions Promoted by Samarium Diiodide. Application to the Synthesis of Indole-Fused Compounds, J. Org. Chem. 63(9): 2909-2917.
[cited by applicant]
Machowinski, et al., (2006). Pityriacitrin—A Potent UV filter Produced by Malassezia furfur and its Effect on Human Skin Microflora. Mycoses; 49(5):388-392.
[cited by applicant]
Manning, et al., (1973). Maintenance of Skin Xenografts of Widely Divergent Phylogenetic Origin on Congenitally Athymic (Nude) Mice. J Exp Med; 138:488-94.
[cited by applicant]
Mayser, et al., (2002). Pityriacitrin—An Ultraviolet-Absorbing Indole Alkaloid from the Yeast Malassezia furfur. Archives of Dermatological Research; 294(3):131-134.
[cited by applicant]
Mayser, et al., (2003). Pityrialactone—A New Fluorochrome from the Tryptophan Metabolism of Malassezia furfur. Antonie van Leeuwenhoek; 84(3):185-191.
[cited by applicant]
Nazzaro-Porro, et al., (1978). Identification of Tyrosinase Inhibitors in Cultures of Pityrosporum. The Journal of Investigative Dermatology; 71:205-208.
[cited by applicant]
Noakes, (2015). The Aryl Hydrocarbon Receptor: A Review of Its Role in the Physiology and Pathology of the Integument and Its Relationship to the Tryptophan Metabolism. Journal of Tryptophan Research; 8:7-18.
[cited by applicant]
Otulakowski, et al., (1994). Use of a Human Skin-Grafted Nude Mouse Model for the Evaluation of Topical Retinoic Acid Treatment. J Invest Dermatol; 102:515-8.
[cited by applicant]
Park, J.I., Lee H.Y., Lee, J.E., Myung, C.H., Hwang, U.S., (2016). Inhibitory Effect of 2-methyl-naphtho[1,2,3-de] quinolin-8-one on melanosome transport and skin pigmentation. Sci. Rep. Jul. 6:6:29189. Doi: 10.1038/sre…
[cited by applicant]
Pillaiyar, et al., “A rapid, efficient and versatile green synthesis of 3,3′-diindolylmethanes”, Arkivoc 2018, part iii, pp. 1-19. (Year: 2017).
[cited by applicant]
Plenat, et al., (1992). Host-Donor Interactions in Healing of Human Split-Thickness Skin Grafts Onto Nude Mice: In Situ Hybridization, Immunohistochemical and Histochemical Studies. Transplantation; 53:1002-10.
[cited by applicant]
Reed, et al., (1973). Long-Term Maintenance of Normal Human Skin on Congenitally Athymic (Nude) Mice. Pmc Soc Exp Biol Med; 143:350-3.
[cited by applicant]
Scott, et al., (1988). The Permeability of Grafted Human Transplant Skin in Athymic Mice. J Pharm Pharmacol; 40:128-9.
[cited by applicant]
Song, et al., (2002). A Ligand for the Aryl Hydrocarbon Receptor Isolated From Lung. PNAS; 99(23):14694-9.
[cited by applicant]
Taylor, et al., (2005). The Taylor Hyperpigmentation Scale: a new visual assessment tool for the evaluation of skin color and pigmentation. Cutis; 76(4):270-4.
[cited by applicant]
Wahlstroem, Niklas et al (2004). Synthesis of 2,3′-diindolylmethanes and substituted indolo[3,2-b]carbazoles, Synthesis (8): 1187-1197.
[cited by applicant]
Wang, et al., (2014). Stress-Induced RNASET2 Overexpression Mediates Melanocyte Apoptosis Via the TRAF2 Pathway In Vitro. Cell Death and Disease; 5:e1022.
[cited by applicant]
Wasmeier, et al., (2008). Melanosomes at a Glance. Journal of Cell Science 2008; 121:3995-3999.
[cited by applicant]
Wille, et al., (2001). Malassezin—A Novel Agonist of the Arylhydrocarbon Receptor From the Yeast Malassezia furfur. Bioorganic & Medicinal Chemistry; 9:955-60.
[cited by applicant]
Winston-McPherson, et al., {2014). Synthesis and Biological Evaluation of 2,3′-diindolylmethanes as Agonists of Aryl Hydrocarbon Receptor. Bioorganic & Medicinal Chemistry Letters; 24:4023-4025.
[cited by applicant]
Whyte, et al., (2000). Ethoxyresorufin-O-deethylase (EROD) Activity in Fish as a Biomarker of Chemical Exposure. Critical Reviews in Toxicology; 30(4):347-570.
[cited by applicant]
Yamaguchi, et al., {2014). Melanocytes and Their Diseases. Cold Spring Harb Perspect Med; 4:a017046.
[cited by applicant]
Zeng, Xio-Fei et al (2005). Novel method for synthesis of unsymmetrical bis(indolyl)alkanes catalyzed by eerie ammonium nitrate (CAN) under ultrasonic irradiation, Tetrahedron 61(43): 10235-10241.
[cited by applicant]
Zonios, et al., (2001). Skin Melanin, Hemoglobin, and Light Scattering Properties can be Quantitatively Assessed In Vivo Using Diffuse Reflectance Spectroscopy. J Invest Dermatol.; 117:1452-1457.
[cited by applicant]
Zhang, et al. {2018). Environmental Adaptability for Quorum Sensing: Regulating Iron Uptake During Biofilm Formation in
[cited by applicant]
S. Luecke et al., “The aryl hydrocarbon receptor (AHR), a novel regulator of human melanogenesis,” Pigment Cell Melanoma Res. 23: 828-833 (2010).
[cited by applicant]
“International Search Report and Written Opinion received for PCT Application No. PCT/US2019/047831”, mailed on Jan. 8, 2020., 17 pages.
[cited by applicant]
Adachi, et al., “Indirubin and Indigo are Potent Aryl Hydrocarbon Receptor Ligands Present in Human Urine”, The Journal of Biological Chemistry, 2001, 276(34):31475-31478.
[cited by applicant]
Costin, et al., “Optimizied in vitro pigmentation screening assay using a reconstructed three-dimensional human skin model.”, Rom. J. Biochem, 2013, 50(1):15-27.
[cited by applicant]
Crisan, et al., “QSAR Study and Molecular Docking on Indirubin Inhibitors of Glycogen Synthase Kinase-3”, Cent. Eur. J. Chem., 2013, 11(1):63-77.
[cited by applicant]
Evdokimov, et al., “Isatin Derivatives with Activity against Apoptosis-resistant Cancer Cells”, Bioorganic & Medicinal Chemistry Letters, 2016, 26(6):1558-1560.
[cited by applicant]
Krämer, et al., “Malassezin, A Novel Agonist of the Aryl Hydrocarbon Receptor from the Yeast Malassezia Furfur, Induces Apoptosis in Primary Human Melanocytes”, Chembiochem, 2005, 6(5):860-865.
[cited by applicant]
Pillaiyar, et al., “Supplementary Material: A rapid, efficient and versatile green synthesis of diindolylmethanes”, Arkivoc, 2018, Part III:S1-S61.
[cited by applicant]
Tholander, et al., “Syntheses of 6, 12-Disubstituted 5,11-Dihydroindolo[3,2-b]carbazoles, Including 5,11-Dihydroindolo[3,2-b]carbazole-6, 12-dicarbaldehyde, an Extremely Efficient Ligand for the TCDD (Ah) Receptor”, Tet…
[cited by applicant]
Tholander, et al., “Syntheses of 6-Substituted Indolo[3,2-b]carbazoles, Including 6-Formylindolo[3,2-b]carbazole, an Extremely Efficient Ligand for the TCDD (Ah) Receptor”, Tetrahedron, 1999, 55:6243-6260.
[cited by applicant]
Tholander, et al., “Synthesis of 6-Formylindolo[3,2-b]carbazole, an Extremely Potent Ligand for the Aryl Hydrogen (Ah) Receptor”, Tetrahedron Letters, Mar. 19, 1998, 39:1619-1622.
[cited by applicant]
Waller, et al., “Three-Dimensional Quantitative Structure-Activity Relationships of Dioxins and Dioxin-like Compounds: Model Validation and Ah Receptor Characterization.”, Chem. Res. Toxicol., 1995, 8:847-858.
[cited by applicant]
Gibbs et al., “Aminocatalytic Preparation of Bisindolylalkanes”, Organic & Biomolecular Chemistry, 2005, 3 (22):4043-4045.
[cited by applicant]
Nguyen et al., “D-Amino Acid Oxidase Generates Agonists of the Aryl Hydrocarbon Receptor from D-Tryptophan”, Chemical Research on Toxicology, 2009, 22(12):1897-1904.
[cited by applicant]
Wahlstrom et al., “Synthesis of Metabolites of the Ah Receptor Ligand 6- Formylindolo[3,2-b]carbazole”, European Journal of Organic Chemistry, 2004, 2004(12):2593-2602.
[cited by applicant]