Medical device with CMUT array and solid state cooling, and associated methods and systems
A medical device includes a capacitive micromachined ultrasonic transducer (CMUT) array configured to emit ultrasound to target tissue, and at least one thermoelectric cooler mechanically coupled with the CMUT array and configured to cool non-target tissue heated by the ultrasound. The medical device may be implemented in a catheter together with a solid thermal conductor coupled to the thermoelectric cooler and extending along the catheter, to conduct heat away from the thermoelectric cooler. A catheter or catheter sleeve includes a tubular wall for insertion into a body channel, and at least one thermoelectric cooler coupled to the tubular wall for cooling the body channel wall. A catheter sleeve includes tubular casing for insertion into a body channel and capable of encasing a catheter, and at least one sensor coupled to the tubular casing for sensing one or more properties of the body channel wall, such as temperature and pressure.
1 . A method for ultrasound treatment with ultrasound imaging feedback, the method comprising:
obtaining an image of a target tissue from an ultrasound transducer array to determine a spatially resolved clutter signal for the target tissue; and
based upon the clutter signal and a predetermined correspondence between the clutter signal and treatment efficacy, determining one or more properties of subsequent generation of ultrasound by the ultrasound transducer array to treat the target tissue,
wherein the predetermined correspondence comprises data determined by:
ultrasonically treating two or more portions of test tissue;
ultrasonically imaging the two or more portions of treated test tissue to obtain spatially resolved clutter signals for the treated test tissue;
determining treatment efficacy based on a degree of necrosis of the two or more portions of treated test tissue; and
comparing the spatially resolved clutter signals and the treatment efficacy results.
2 . The method according to claim 1 , wherein the method comprises repeatedly performing the step of obtaining an image of target tissue to update the spatially resolved clutter signal, and repeatedly revising the step of determining the one or more properties of subsequent generation of ultrasound in accordance with the spatially resolved clutter signal as updated, to update the one or more properties.
3 . The method according to claim 1 , wherein the method further comprises commanding the ultrasound transducer array to generate the ultrasound having the one or more properties.
4 . The method according to claim 1 , wherein the method comprises alternatingly performing the steps of obtaining an image of target tissue and commanding the ultrasound array to generate the ultrasound.
5 . The method according to claim 1 , wherein the step of determining the one or more properties of subsequent generation of ultrasound further comprises taking into account a measurement of temperature of non-target tissue heated by the ultrasound, to determine the one or more properties.
6 . The method according to claim 5 , wherein the target tissue comprises prostate tissue, and the non-target tissue comprises tissue of a portion of a urethral wall.
7 . The method according to claim 5 , wherein the method further comprises at least temporarily ceasing the generation of ultrasound when the temperature as measured of the non-target tissue exceeds a threshold temperature.
8 . The method according to claim 1 , wherein the step of determining the one or more properties of subsequent generation of ultrasound further comprises taking into account measurement of one or both of temperature and pressure of non-target tissue heated by the ultrasound, to determine the one or more properties.
9 . The method according to claim 8 , wherein the target tissue comprises prostate tissue, and the non-target tissue comprises tissue of a portion of a urethral wall.
10 . The method according to claim 1 , wherein the step of determining the one or more properties of subsequent generation of ultrasound comprises determining intensity of the ultrasound to be subsequently generated by the ultrasound transducer array as a function of position within the target tissue.
11 . The method according to claim 10 , further comprising commanding the ultrasound transducer array to beamform the ultrasound according to the intensity as a function of position as determined in the step of determining the one or more properties of subsequent generation of ultrasound.
12 . The method according to claim 11 , wherein the step of commanding the ultrasound transducer array to beamform the ultrasound comprises commanding the ultrasound transducer array to focus the ultrasound on one or more localized regions of the target tissue.
13 . The method according to claim 1 , wherein in the step of obtaining an image of target tissue from an ultrasound transducer array comprises obtaining an image of a prostate, and wherein the step of determining the one or more properties of subsequent generation of ultrasound comprises utilizing a prostate-tissue specific, predetermined correspondence between the clutter signal and treatment efficacy to determine the one or more properties applicable to prostate tissue, to enable ultrasound treatment of a prostate.
14 . The method according to claim 1 , wherein the step of determining the one or more properties of subsequent generation of ultrasound comprises selecting the predetermined correspondence from a selection of blood-perfusion specific correspondences.
15 . The method according to claim 14 , wherein the method further comprises evaluating a degree of blood perfusion of the target tissue from a Doppler image of the target tissue generated by the ultrasound transducer array, and wherein the step of determining the one or more properties of subsequent generation of ultrasound further comprises selecting the predetermined correspondence from the selection of blood-perfusion specific correspondences according to the degree of blood perfusion.
16 . The method according to claim 1 , wherein machine-readable instructions encoded in non-transitory memory, comprise (a) a correspondence between an ultrasound clutter signal and efficacy of the ultrasound treatment, and (b) treatment control instructions that, when executed by a processor, evaluate spatially resolved clutter signals obtained from ultrasound imaging of target tissue and utilize the correspondence to determine one or more properties of subsequent ultrasound exposure of the target tissue.
17 . The method according to claim 1 , wherein the method further comprises a step of cooling non-target tissue to prevent damage to the non-target tissue.
18 . The method according to claim 17 , wherein the method further comprises commanding the ultrasound transducer array to generate the ultrasound having the one or more properties to expose the target tissue to the generated ultrasound, wherein the target tissue comprises the prostate, and wherein the ultrasound array is positioned within a urethra.
19 . The method according to claim 18 , wherein the non-target tissue comprises at least a portion of the tissue of the urethral wall.
20 . The method according to claim 17 , wherein the step of cooling the non-target tissue comprises cooling the non-target tissue with a device comprising a cooling assembly selected from the group consisting of: a solid-state cooling assembly; a liquid cooling assembly; and combinations thereof.
21 . The method according to claim 20 , wherein the device comprises the cooling assembly and the ultrasound transducer array.
22 . The method according to claim 1 , wherein the ultrasound transducer array comprises a capacitive micromachined ultrasonic transducer (CMUT) array.