Granted Patent B2

US 12,521,550 · App. 18/473,533 · Granted Jan 13, 2026

Inventors: Eric A. Schepis (Alpharetta, GA); Amol Soin (Dayton, OH)

Assignee: Soin Neuroscience, LLC

A61N1/0529A61N1/056A61N1/36071

Abstract

Claims (53)

1 . A system for providing therapy to a patient, the system comprising:

at least one electrode;

at least one noise generator coupled to the at least one electrode; and

a controller comprising at least one processor and at least memory having a plurality of instructions stored thereon that, in response to execution by the at least one processor, causes the controller to:

instruct the at least one noise generator to generate an electrical noise signal;

partition the electrical noise signal into a plurality of discrete frequency bands, each of the discrete frequency bands having a corresponding bandwidth;

deliver the electrical noise signal through the at least one electrode to the patient to target at least one of neural tissue or non-neural tissue of the patient;

adjust an amplitude of one or more of a voltage or current of the electrical noise signal within a selected frequency band of the plurality of discrete frequency bands to generate an adjusted electrical signal based on feedback received from the patient; and

deliver the adjusted electrical signal through the at least one electrode to provide therapy to the patient.

2 . The system of claim 1 , wherein the feedback received from the patient is patient self-report regarding the therapy delivered to the patient.

3 . The system of claim 1 , further comprising at least one sensor configured to measure one or more physiological outcomes of the patient; and

wherein the feedback is based on data generated by the at least one sensor.

4 . The system of claim 1 , wherein the feedback comprises data received from a machine learning system.

5 . The system of claim 1 , wherein to adjust the amplitude of one or more of the voltage or current of the electrical noise signal within the selected frequency band of the plurality of discrete frequency bands comprises to adjust the amplitude of the voltage of the electrical noise signal within the selected frequency band of the plurality of discrete frequency bands.

6 . The system of claim 5 , wherein the amplitude of the voltage of the electrical noise signal within the selected frequency band of the plurality of discrete frequency bands is adjustable within a range of 0.01 V to 200 V.

7 . The system of claim 5 , wherein the amplitude of the voltage of the electrical noise signal within the selected frequency band of the plurality of discrete frequency bands is adjustable within a range of 0.1 V to 100 V.

8 . The system of claim 5 , wherein the amplitude of the voltage of the electrical noise signal within the selected frequency band of the plurality of discrete frequency bands is adjustable within a range of 0.5 V to 50 V.

9 . The system of claim 1 , wherein to adjust the amplitude of one or more of the voltage or current of the electrical noise signal within the selected frequency band of the plurality of discrete frequency bands comprises to adjust the amplitude of the current of the electrical noise signal within the selected frequency band of the plurality of discrete frequency bands.

10 . The system of claim 1 , wherein to partition the electrical noise signal into the plurality of discrete frequency bands comprises to partition the entire frequency range of the electrical noise signal into the plurality of discrete frequency bands.

11 . The system of claim 1 , wherein the at least one noise generator consists of a single noise generator.

12 . The system of claim 1 , wherein the at least one noise generator comprises a first noise signal generator and a second noise signal generator;

wherein to instruct the at least one noise generator to generate the electrical noise signal comprises to (i) instruct the first noise signal generator to generate a first electrical noise signal within a first frequency band of the plurality of discrete frequency bands and (ii) instruct the second noise signal generator to generate a second electrical noise signal within a second frequency band of the plurality of discrete frequency bands; and

wherein the electrical noise signal is compiled from at least the first electrical noise signal and the second electrical noise signal.

13 . The system of claim 1 , wherein the at least one noise generator is configured to generate the electrical noise signal based on one or more of subtractive synthesis, additive synthesis, component modeling synthesis, wavetable synthesis, vector synthesis, linear arithmetic synthesis, phase distortion synthesis, frequency modulation synthesis, sample-based synthesis, or random number generation.

14 . The system of claim 1 , wherein to adjust the amplitude of one or more of the voltage or current of the electrical noise signal within the selected frequency band of the plurality of discrete frequency bands comprises to:

adjust an amplitude of one or more of the voltage or current of the electrical noise signal within a first frequency band of the plurality of discrete frequency bands to a first amplitude; and

adjust an amplitude of one or more of the voltage or current of the electrical noise signal within a second frequency band of the plurality of discrete frequency bands to a second amplitude different from the first amplitude.

15 . The system of claim 1 , wherein each of the discrete frequency bands has the same bandwidth.

16 . The system of claim 1 , wherein each of the discrete frequency bands is an octave band.

17 . The system of claim 1 , wherein the at least one noise generator comprises a filter bank having a plurality of bandpass filters;

wherein each bandpass filter of the plurality of bandpass filters is associated with a corresponding discrete frequency band of the plurality of discrete frequency bands such that the bandpass filter passes signal frequencies within the corresponding bandwidth; and

wherein to partition the electrical noise signal into the plurality of discrete frequency bands comprises to process the electrical noise signal with the filter bank.

18 . A system for providing electrical stimulation therapy to a patient, the system comprising:

at least one electrode;

at least one noise generator coupled to the at least one electrode; and

a controller comprising at least one processor and at least memory having a plurality of instructions stored thereon that, in response to execution by the at least one processor, causes the controller to:

instruct the at least one noise generator to generate an electrical noise signal;

partition the electrical noise signal into a plurality of discrete frequency bands, each of the discrete frequency bands having a corresponding bandwidth;

deliver the electrical noise signal through the at least one electrode to the patient to target tissue of the patient;

adjust one or more of an amplitude of a voltage of the electrical noise signal, an amplitude of a current of the electrical noise signal, or a phase component of the electrical noise signal within a selected frequency band of the plurality of discrete frequency bands to generate an adjusted electrical signal; and

deliver the adjusted electrical signal through the at least one electrode to provide the electrical stimulation therapy to the patient.

19 . A system for providing electrical stimulation therapy to a patient, the system comprising:

at least one electrode;

at least one signal generator coupled to the at least one electrode; and

a controller comprising at least one processor and at least memory having a plurality of instructions stored thereon that, in response to execution by the at least one processor, causes the controller to:

instruct the at least one signal generator to generate an electrical stimulation signal;

partition the electrical stimulation signal into a plurality of discrete frequency bands, each of the discrete frequency bands having a corresponding bandwidth;

deliver the electrical stimulation signal through the at least one electrode to the patient to target at least one of neural tissue or non-neural tissue of the patient;

adjust, for each of a plurality of selected frequency bands of the plurality of discrete frequency bands, a corresponding amplitude of one or more of a voltage or current of the electrical stimulation signal within a corresponding frequency band of the plurality of discrete frequency bands to generate an adjusted electrical stimulation signal based on feedback received from the patient; and

deliver the adjusted electrical signal through the at least one electrode to provide the electrical stimulation therapy to the patient.

20 . The system of claim 19 , wherein to adjust, for each of the plurality of selected frequency bands of the plurality of discrete frequency bands, the corresponding amplitude of one or more of the voltage or current of the electrical stimulation signal within the corresponding frequency band of the plurality of discrete frequency bands comprises to:

adjust an amplitude of one or more of the voltage or current of the electrical stimulation signal within a first frequency band of the plurality of discrete frequency bands based on first feedback received from the patient to generate a first adjusted electrical stimulation signal; and

adjust an amplitude of one or more of the voltage or current of the first adjusted electrical stimulation signal within the second frequency band of the plurality of discrete frequency bands based on second feedback received from the patient to generate a second adjusted electrical stimulation signal.

Assignments (3)

Continuity (4)

References Cited (38)