IP Library › Granted Patent US 12,527,963
Granted Patent B2
US 12,527,963 · App. 17/601,337 · Granted Jan 20, 2026

Magnetoelectric data and power to miniature biodevices with tunable amplitude and waveform

Inventors: Jacob Robinson (Houston, TX); Kaiyuan Yang (Houston, TX); Zhanghao Yu (Houston, TX); Joshua Chen (Diamond Bar, CA); Amanda Singer (Houston, TX); Benjamin Avants (Houston, TX); Nishant Verma (Houston, TX)
Assignee: William Marsh Rice University
A61N1/37223A61N1/3787H10N35/101H10N35/80H10N35/85
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 12,527,963
App. No.
17/601,337
Granted
Jan 20, 2026
Kind
B2
Abstract

The disclosure describes new apparatus, systems and methods utilizing magnetoelectric neural stimulators with tunable amplitude and waveform. Specific embodiments of the present disclosure include a magnetoelectric film, a magnetic field generator and an electrical circuit coupled to the magnetoelectric film, in particular embodiments, the electrical circuit comprises components configured modify an electrical output signal produced by the magnetoelectric film. In certain embodiments, the electrical circuit is configured to modify the electric signal to charge a charge storage element, to transmit data to an implantable wireless neural stimulator, and to provide a stimulation output to electrodes.

Claims (42)

1 . A system comprising:

a magnetoelectric film;

a magnetic field generator configured to generate a magnetic field at an input frequency between 20-500 kHz, wherein the magnetic field generator is configured to transmit downlink data by performing amplitude shift keying (ASK) modulation of the magnetic field; and

an electrical circuit coupled to the magnetoelectric film, wherein:

the magnetoelectric film is configured to produce an electrical output signal when the magnetoelectric film is stimulated by the magnetic field at the input frequency;

the electrical circuit configured to receive the electrical output signal comprises:

a charging circuit configured to extract power based on the electrical output signal;

a stimulation driver configured to modify the electrical output signal such that the electrical output signal has an output frequency between 0.5-1000 Hz to stimulate a biological tissue; and

a data circuit configured to recover the downlink data encoded via the amplitude shift keying (ASK) modulation of the magnetic field; and

the electrical circuit is configured to transition between the power, the stimulation and the data recovery based on modulation of the magnetic field.

2 . The system of claim 1 wherein:

the magnetoelectric film comprises a central portion; and

the electrical circuit is coupled to the central portion of the magnetoelectric film.

3 . The system of claim 1 wherein: the magnetoelectric film has a resonant frequency; and

the input frequency is within ten percent of the resonant frequency of the magnetoelectric film.

4 . The system of claim 1 wherein the magnetic field generator is configured to generate a series of pulses of the magnetic field.

5 . The system of claim 4 wherein each pulse in the series of pulses has a duration of approximately 1 millisecond (ms).

6 . The system of claim 4 wherein: the electrical output signal has an output voltage; and

an amplitude of the output voltage depends on a duration of pulses in the series of pulses.

7 . The system of claim 4 wherein: the electrical output signal has an output voltage; and

an amplitude of the output voltage depends on a total number of pulses in the series of pulses.

8 . The system of claim 1 wherein the electrical output signal is a monophasic or biphasic output signal.

9 . The system of claim 1 wherein the magnetoelectric film comprises a magnetostrictive layer and a piezoelectric layer; a polyvinylidene fluoride (PVDF) layer; or a lead zirconate titanate (PZT) layer.

10 . The system of claim 1 , further comprising an electronic device, wherein the electrical output signal powers the electronic device.

11 . The system of claim 1 wherein the magnetoelectric film is a first magnetoelectric film, wherein the apparatus further comprises a second magnetoelectric film, and wherein the electrical circuit is coupled to the second magnetoelectric film.

12 . The system of claim 1 wherein the magnetic field generator comprises an electromagnet.

13 . The system of claim 1 wherein the magnetic field generator further comprises a permanent magnet.

14 . The system of claim 1 wherein the electrical components comprise a full wave rectifier and a transistor.

15 . The system of claim 1 wherein the electrical components comprise a diode and a capacitor.

16 . The system of claim 1 wherein the apparatus further comprises a stereotrode and wherein the electrical output signal is transmitted through the stereotrode.

17 . The system of claim 1 wherein the magnetic field generator configured to generate the magnetic field at the input frequency within five percent of the resonant frequency of the magnetoelectric film.

18 . The system of claim 1 , wherein:

prior to transmitting the downlink data, the magnetic field generator is configured to transmit a pilot tone as an unmodulated portion of the magnetic field that is received by the electrical circuit via the magnetoelectric film; and

the electrical circuit is configured to extract a threshold voltage based on the pilot tone to decode the downlink data.

19 . A system comprising:

a magnetoelectric film;

a magnetic field generator configured to generate a magnetic field at an input frequency between 20-500 kHz, wherein the magnetoelectric film is configured to produce an electrical output signal with a voltage waveform when the magnetoelectric film is stimulated by the magnetic field at the input frequency; and

an electrical circuit or material coupled to the magnetoelectric film to modify the voltage waveform, wherein:

the magnetic field generator is configured to transmit downlink data to control at least part of the system by performing amplitude shift keying modulation of the magnetic field; and

the electrical circuit or material comprises electric components configured to:

modify the electrical output signal such that the electrical output signal has an output frequency between 0.5-1000 Hz; and

recover the downlink data encoded via the amplitude shift keying modulation of the magnetic field.

Assignments (2)
CONFIRMATORY LICENSE Recorded Jan 29, 2025
From: RICE UNIVERSITY
To: NATIONAL SCIENCE FOUNDATION
Reel/Frame 070054/0155 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 8, 2023
From: ROBINSON, JACOB; YANG, KAIYUAN; YU, ZHANGHAO; CHEN, JOSHUA; SINGER, AMANDA; AVANTS, BENJAMIN; VERMA, NISHANT
To: WILLIAM MARSH RICE UNIVERSITY
Reel/Frame 065809/0564 →
Continuity (3)
Provisional Application 62976051 · Feb 13, 2020
Provisional Application 62830089 · Apr 5, 2019
Related Publication 20220168579A1 · Jun 2, 2022
References Cited (28)
US 5630836A · Prem · 1997 [cited by examiner]
US 20070282378A1 · Huang et al. · 2007 [cited by applicant]
US 20090062886A1 · O'Handley · 2009 [cited by examiner]
US 20110125203A1 · Simon et al. · 2011 [cited by applicant]
US 20130289913A1 · Jahns et al. · 2013 [cited by applicant]
US 20140277268A1 · Lee · 2014 [cited by applicant]
US 20150082919A1 · Higashi et al. · 2015 [cited by applicant]
US 20160270927A1 · Zellmer et al. · 2016 [cited by applicant]
US 20180053890A1 · Kang et al. · 2018 [cited by applicant]
US 20180085593A1 · Fayram et al. · 2018 [cited by applicant]
US 20180093099A1 · Cogan et al. · 2018 [cited by applicant]
US 20180231621A1 · Higashi et al. · 2018 [cited by applicant]
Wickens et al., “Magnetoelectric materials for miniature, wireless neural stimualation at therapeutic frequencies”. (Year: 2018). [cited by examiner]
Bayrashev et al., “Low frequency wireless powering of microsystems using piezoelectric-magnetostrictive laminate composites,” [cited by applicant]
Bayrashev et al., “Low frequency wireless powering of microsystems using piezoelectric-magnetostrictive laminate composites,” [cited by applicant]
Extended European Search Report issued in European Application No. 20784948.0, mailed Nov. 15, 2022. [cited by applicant]
Fernando et al., “An embedded wireless neural stimulation and recording system,” Conference on Neural Engineering, 2007. [cited by applicant]
Jin et al., “Multiferroic polymer composites with greatly enhanced magnetoelectric effect under a low magnetic bias,” [cited by applicant]
Kambale et al., “Magnetoelectric properties and magentomechanical energy harvesting from stray vibration and electromagnetic wave by Pb(Mg [cited by applicant]
Kopaei et al., “A novel hybrid approach for wireless powering of biomedical implants,” [cited by applicant]
Martins et al., “Polymer-based magnetoelectric materials,” [cited by applicant]
PCT International Search Report and Written Opinion issued in International Application No. PCT/US2020/026688, mailed Aug. 12, 2020. [cited by applicant]
Pietronave et al., “Monophasic and biphasic electrical stimulation induces a precardiac differentiation in progenitor cells isolated from human heart,” [cited by applicant]
Ribeiro et al., “Proving the suitability of magnetoelectric stimuli for tissue engineering applications,” [cited by applicant]
Wickens et al., “Magnetoelectric materials for miniature, wireless neural stimulation at therapeutic frequencies,” bioRxiv, 2018. [cited by applicant]
Yue et al., “Magneto-electric nano-particles for non-invasive brain stimulation,” [cited by applicant]
Office Action for European Application No. 24160436.2, dated May 14, 2025, 6 Pages. [cited by applicant]
Office Action for European Application No. 24160440.4, dated May 14, 2025, 6 Pages. [cited by applicant]