Granted Patent
B2
US 12,528,842 · App. 17/310,205 · Granted Jan 20, 2026
Method of producing transduction particles
Assignee:
SNIPR Biome ApS
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Abstract
The invention relates to the production of transduction particles, such as phage, as well as compositions comprising the particles and use of these. The particles are particularly useful for delivering toxic payloads into target bacteria for antibacterial action. The invention is also useful for the production of wild-type (“native”) phage and phage cocktails comprising different types of phage. Embodiments enable production of compositions of such particles for use in medical, environmental or food production settings.
Claims (21)
1 . A method of producing transduction particles wherein the particles are capable of recognizing a receptor on bacterial target cells for transduction of the cells, the method comprising producing the particles in bacterial producer cells, wherein the bacterial producer cells do not express the receptor on their surface,
wherein the production yield of transduction particles is enhanced compared to production in bacterial producer cells that express the receptor on their surface.
2 . The method of claim 1 , wherein the bacterial producer and bacterial target cells are cells of the same species.
3 . The method of claim 1 , wherein the bacterial producer cells are E. coli cells.
4 . The method of claim 1 , wherein the transduction particles comprise a phage capsid, wherein the capsid comprises a packaged nucleic acid of interest (NSI) for transduction into bacterial target cells.
5 . The method of claim 4 , wherein the NSI comprises or encodes an antibacterial agent that kills bacterial target cells, or wherein the NSI comprises or encodes a component of such an agent.
6 . The method of claim 5 , wherein the NSI comprises a nucleotide sequence encoding a guide RNA of a CRISPR/Cas system.
7 . The method of claim 1 , wherein the transduction particles are phages.
8 . The method of claim 1 , wherein the transduction particles are non-self-replicative.
9 . The method of claim 1 , wherein the genome of each bacterial producer cell comprises a genetic modification that disrupts synthesis of the receptor and/or its expression as a cell surface receptor.
10 . The method of claim 9 , wherein the modification is a modification of a lipopolysaccharide (LPS) synthesis pathway.
11 . The method of claim 1 , wherein the receptor comprises an LPS.
12 . The method of claim 1 , wherein the yield is increased at least 10-fold compared to production in bacterial producer cells that surface-express the receptor.
13 . The method of claim 12 , wherein the yield is increased at least 100-fold.
14 . The method of claim 12 , wherein the yield is increased 10- to 1000-fold.
15 . The method of claim 1 , comprising isolating the transduction particles from cellular material to obtain a composition comprising the transduction particles.
16 . The method of claim 15 , wherein the composition comprises no bacterial producer cell LPS.
17 . The method of claim 1 , wherein the bacterial target cells are Escherichia, Klebsiella, Clostridium or Pseudomonas cells.
18 . The method of claim 1 , wherein the bacterial target cells are E. coli, K. pneumoniae, C. difficile or P. aeruginosa cells.
19 . The method of claim 1 , wherein the transduction particles comprise a P2 phage capsid and the receptor is a P2 receptor.
20 . The method of claim 1 , further comprising infecting bacterial producer cells not expressing the receptor on their surface to produce the transduction particles.
Assignments (2)
CORRECTIVE ASSIGNMENT TO CORRECT THE ASSIGNORS NAME PREVIOUSLY RECORDED AT REEL: 57126 FRAME: 101. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT.
Recorded Aug 22, 2025
From: SEMSEY, SZABOLCS
To: SNIPR BIOME APS
Reel/Frame 072528/0015 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Aug 9, 2021
From: SZABOLCS, SEMSEY
To: SNIPR BIOME APS
Reel/Frame 057126/0101 →
Priority Claims (1)
GB 1901099
· Jan 27, 2019
· national
Continuity (1)
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