Micellar disinfectants
The present disclosure relates to micellar compositions conformed by biomimetic phospholipids and nonionic surfactants, among other ingredients, for eliminating one or more types of microorganisms including mycobacteria, bacteria, fungi, and viruses from a surface within a contact time on the surface of less than about 1 minutes and having pH of from about 0.3 to 8. The present invention aims on using 100% bio-based (renewable) biodegradable, non-toxic ingredients to be applied not only to hard inanimate surfaces but also on tissue for endodontic applications.
1 . A physically and chemically stable micellar composition for eliminating one or more of bacteria, fungi, and viruses from a surface, the composition comprises:
a micelle;
a phospholipid;
a surfactant, consisting of a nonionic surfactant; hydrogen peroxide; and
aromatic carboxylic acid and/or aromatic dicarboxylic acid; or tricarboxylic acid; and/or aromatic hydroxy carboxylic acid and/or aromatic dihydroxy; or trihydroxy mono or di carboxylic acid,
wherein the composition eliminates one or more of bacteria, fungi, viruses from a surface within a contact time of less than 1 minute;
wherein the micellar composition is physically and chemically stable and has a shelf life exceeding two years.
2 . The composition according to claim 1 wherein a pH is from about 0.3 to 8.
3 . The composition according to claim 1 wherein the phospholipid is alkyl amide propyl-propylene glycol-dimonium chloride phosphate; the nonionic surfactant is a polyglyceryl fatty acid ester or an alkyl (C5 to Cl 8) ethoxylate (4 to 16) surfactant or their polydisperse mixture, or alkylpolysaccharides or polyoxyethylene derivatives of sorbitan esters or a combination thereof.
4 . The composition according to claim 3 wherein the phospholipid is in concentrations of about 0.3 to 10% w/w relative to the total weight of the micellar composition; the nonionic surfactant is in a concentration of from 0 to 10% w/w of the total weight of the micellar composition; the hydrogen peroxide is in a concentration of about 0.1 to 2.9% w/w relative to the total weight of the micellar composition; and/or the aromatic carboxylic acid and/or aromatic dicarboxylic or tricarboxylic acid, and/or aromatic hydroxy carboxylic acid, aromatic dihydroxy mono or di carboxylic acid is in a concentration of about 0.01 to 1% w/w relative to the total weight of the micellar composition.
5 . The composition according to claim 1 wherein the phospholipid is Myristamidopropyl PG-Dimonium Chloride Phosphate, or Cocamidopropyl PG-Dimonium Chloride Phosphate, or Linoleamidopropyl PG-dimonium Chloride Phosphate or a combination thereof.
6 . The composition according to claim 3 wherein the alkylpolysaccharides is D-Glucopyranose, or oligomeric, decyl-octyl glycoside and the polyoxyethylene derivatives of sorbitan esters is POE (20) sorbitan monopalmitate or POE (20) sorbitan monooleate; or the polyglyceryl fatty acid ester is polyglyceryl-10 caprylate/caprate, or polyglyceryl-4 laurate/sebacate and polyglyceryl-4 caprylate/caprate, or polyglyceryl-4 laurate/sebacate and polyglyceryl-6 caprylate/caprate or a combination thereof.
7 . The composition according to claim 1 wherein the aromatic carboxylic acid is benzoic acid.
8 . The composition according to claim 1 further comprising:
a saturated alkyl mono, di, or tri hydroxy carboxylic acid; and/or
an unsaturated alkyl dicarboxylic acid; and
further comprising:
an aromatic alpha hydroxy acid;
an ortho, para or beta aminobenzoic acid;
5-pyrrolidone-2-carboxylic acid;
ascorbic acid;
aspartic acid;
praline;
glycine;
urea; and
further comprising: an aromatic glycol ether;
one anticorrosive;
one organic salt;
inorganic salts;
inorganic salts; or
a combinations thereof.
9 . The composition according to claim 8 wherein the saturated alkyl mono, di, or tri hydroxy carboxylic acid in a concentration from about 0.01 to 5% w/w relative to the total weight of the micellar composition; wherein the aromatic alpha hydroxy acid, and/or ortho, para or beta aminobenzoic acid, and/or 5-pyrrolidone-2-carboxylic acid, and/or ascorbic acid, and/or aspartic acid, and/or praline and/or glycine and/or urea in a concentration of 0.01 to 3% w/w relative to the total weight of the micellar composition; wherein the at least an aromatic glycol ether is from 0.5 to 5% w/w relative to the total weight of the micellar composition; wherein the anticorrosive is in a concentration of from 0.01 to 1%; wherein the organic salt is in a concentration from of 0.01 to 2%.
10 . The composition according to claim 8 wherein the aromatic glycol ether is phenoxyethanol; wherein the at least one anticorrosive is benzotriazole; wherein the organic salt is a salt of an alkali metal, a salt of an alkaline earth metal, the alkali metal comprising lithium, sodium, or potassium citrate, the alkaline earth metal comprising calcium or magnesium citrate, sodium or calcium benzoate, sodium EDTA, or magnesium acetate or a mixture of thereof; wherein the at least one organic salt is sodium citrate or functions as anticorrosive or chelant or PH adjuster or kosmotrophe, or a combination thereof; wherein the inorganic salt is a salt of an alkali metal, a salt of an alkaline earth metal, the alkali metal comprising lithium, sodium or potassium chloride, the alkaline earth metal comprising calcium or magnesium chloride, or magnesium nitrate or mixture thereof; wherein the inorganic salt is a salt of an alkali metal, a salt of an alkaline earth metal; and/or wherein the inorganic salt is lithium, sodium or potassium chloride, calcium or magnesium chloride, or magnesium nitrate or mixture thereof.
11 . The composition according to claim 1 wherein the composition is formulated to solubilize poorly soluble disinfecting components; is formulated to solubilize very slightly soluble (0.1-1 mg/ml), slightly soluble (1-10 mg/ml), sparingly soluble (10-33 mg/ml), soluble (33-100 mg/ml), and/or freely soluble (100-1000 mg/ml) disinfecting components; and/or is formulated such that the micelle has a range of from about 4 to about 30 nm or from about 20 to about 50 nm.
12 . The composition according to claim 1 wherein the surface is a non-porous surface or a porous surface.
13 . The composition of claim 12 wherein the surface is a table or a tooth.
14 . The composition according to claim 1 wherein a pH of the composition is from about 2 to 4.
15 . A method to disinfect a surface from one or more of bacteria, fungi, viruses, the method comprising:
applying the composition of claim 1 to the surface to disinfect the surface from one or more of bacteria, fungi, and viruses within a contact time on the surface of less than 1 minute.
16 . A physically and chemically stable endodontic irrigant micellar composition for use in treating or eliminating bacteria and/or bacterial products within a root canal, the composition comprises:
a. a micelle;
b. a phospholipid;
c. a nonionic surfactant;
d. hydrogen peroxide; and
e. aromatic carboxylic acid and/or aromatic dicarboxylic acid; or tricarboxylic acid; and/or aromatic hydroxy carboxylic acid and/or aromatic dihydroxy; or trihydroxy mono or di carboxylic acid,
wherein the composition treats or eliminates bacteria from a root canal within a contact time of less than 1 minute.
17 . The composition of claim 16 wherein a pH of the composition is from about 4 to about 8.
18 . A method of disinfecting a root canal comprising contacting a tooth with the composition of claim 16 .
19 . A chemically and physically stable micellar composition for eliminating one or more of bacteria, fungi, and viruses from a surface, the composition comprises:
a micelle;
a phospholipid;
a surfactant, consisting of a nonionic and non-phosphorus surfactant; hydrogen peroxide; and
non-phosphate containing acids, the non-phosphate containing acids comprising:
aromatic carboxylic acid;
aromatic dicarboxylic or tricarboxylic acid;
aromatic hydroxy carboxylic acid;
aromatic dihydroxy, or trihydroxy mono or di carboxylic acid,
wherein the composition eliminates one or more of bacteria, fungi, viruses from a surface within a contact time of less than 1 minute;
wherein the micellar composition is physically and chemically stable and has a shelf life exceeding two years.