Biochemical analysis instrument
An analysis instrument comprises plural modules connected together over a data network, each module comprising an analysis apparatus operable to perform biochemical analysis of a sample. Each module comprises a control unit that controls the operation of the analysis apparatus. The control units are addressable to select an arbitrary number of modules to operate as a cluster for performing a common biochemical analysis. The control units communicate over the data network, repeatedly during the performance of the common biochemical analysis, to determine the operation of the analysis apparatus of each module required to meet the global performance targets, on the basis of measures of performance derived from the output data produced by the modules. The arrangement of the instrument as modules interacting in this manner provides a scalable analysis instrument.
1 . A method for supplying sample into a nanopore sensor device comprising a plurality of nanopores, the method comprising automatically controlling a fluidics system mounted on a body to supply sample from a reservoir mounted on the body to an inlet of the sensor device;
wherein the fluidics system comprises supply channels and inlet pumps configured for pumping fluids from reservoirs, including the reservoir, to the sensor device;
wherein the fluidics system comprises an output pump configured for pumping fluids out of the sensor device through an outlet channel connected to a waste reservoir configured for disposal of the fluids; and
wherein the fluidics system comprises a selector valve disposed in supply channels between the inlet pumps connected to the reservoirs and the output pump, wherein the selector valve is configured to selectively connect the sensor device to the reservoirs, and wherein the selector valve is configured to selectively connect the sensor device to the waste reservoir.
2 . The method of claim 1 , wherein automatically controlling the fluidics system comprises automatically controlling the fluidics system using a controller to supply sample from a reservoir mounted on the body to an inlet of the sensor device.
3 . The method of claim 2 , wherein the controller is controlled by a control module that is implemented in an embedded computer by software executed thereon.
4 . The method of claim 1 , wherein the body is configured for attachment of a well plate, which may be filled with samples.
5 . The method of claim 1 , wherein the sample comprises an analyte selected from the group consisting of DNA, RNA, polynucleotides, protein, and small molecule.
6 . The method of claim 1 , wherein the sensor device comprises a sensor device body in which there is formed a plurality of recesses, each recess having an electrode arranged therein, wherein an amphiphilic membrane is formed across each recess and each of the plurality of nanopores is inserted into the amphiphilic membrane across a corresponding recess.
7 . The method of claim 6 , wherein the sensor device body is covered by a cover that extends over the sensor device body and is hollow to define a chamber into which each recess opens, wherein a common electrode is disposed within the chamber outside of the recesses.