Fast T2-weighted and diffusion-weighted chirped-CPMG sequences
Various systems and methods for T2-weighted and/or diffusion weighted chirped-CPMG sequences are disclosed herein. In one aspect, a method can include projecting a magnetic field along a longitudinal axis and toward an object of interest and transmitting a radio frequency pulse sequence to a radio frequency coil assembly configured to selectively excite magnetization in the object of interest. The radio frequency pulse sequence can include a frequency-swept excitation pulse and a series of frequency-swept refocusing pulses following the excitation pulse. In some aspects, the radio frequency pulse sequence can include a frequency-swept recovery pulse following the series of refocusing pulses. In some aspects, the method can include transmitting a preparation radio frequency pulse sequence to the radio frequency coil assembly.
1 . A method, comprising:
projecting a magnetic field along a longitudinal axis and toward an object of interest located within a field of view;
transmitting a preparation radio frequency pulse sequence to a radio frequency coil assembly configured to selectively excite magnetization in the object of interest within the field of view, wherein the preparation radio frequency pulse sequence comprises:
a first preparation pulse that is frequency swept across the frequency offset range at the first rate, wherein the first preparation pulse is a 90° pulse;
a second preparation pulse that is frequency swept across the frequency offset range at the second rate, wherein the second preparation pulse is a 180° pulse; and
a third preparation pulse that is frequency swept across the frequency offset range at the first rate, wherein the third preparation pulse is a 90° pulse:
transmitting a radio frequency pulse sequence to the radio frequency coil assembly, wherein the radio frequency pulse sequence comprises:
an excitation pulse that is frequency swept across a frequency offset range;
a series of refocusing pulses following the excitation pulse, wherein each of the refocusing pulses are frequency swept across the frequency offset range, and wherein each of the refocusing pulses are half the duration of the excitation pulse; and
a recovery pulse following the series of refocusing pulses, wherein the recovery pulse is frequency swept across the frequency offset range;
wherein the excitation pulse and the recovery pulse are frequency swept across the frequency offset range at a first rate, wherein the refocusing pulses are frequency swept across the frequency offset range at a second rate, and wherein the second rate is twice the first rate; and
receiving an output signal detected by the radio frequency coil assembly an intermediate two of the refocusing pulses.
2 . The method of claim 1 , wherein the radio frequency pulse sequence is a primary radio frequency pulse sequence, wherein the the preparation radio frequency pulse sequence to the radio frequency coil assembly prior to transmitting the primary radio frequency pulse sequence, and wherein the preparation radio frequency pulse sequence is configured to achieve T2 weighted imaging or diffusion weighted imaging.
3 . The method of claim 2 , further comprising sequentially repeating the transmission of the preparation radio frequency pulse sequence and the primary radio frequency pulse sequence.
4 . The method of claim 3 , wherein the excitation pulse is a 90° pulse, wherein each of the refocusing pulses are 180° pulses, and wherein the recovery pulse is a 90° pulse.
5 . The method of claim 4 , wherein the excitation pulse comprises a first phase ϕ 1 , wherein the recovery pulse comprises a second phase ϕ 2 , and wherein the second phase ϕ 2 equals the first phase ϕ 1 plus 180°.
6 . The method of claim 5 , wherein the series of refocusing pulses comprises sequentially repeating first and second refocusing pulses.
7 . The method of claim 6 , wherein receiving an output signal detected by the radio frequency coil assembly intermediate two of the refocusing pulses comprises receiving multiple output signals from the radio frequency coil assembly, wherein each of the multiple output signals are detected intermediate one of the first refocusing pulses and one of the second refocusing pulses.
8 . The method of claim 7 , wherein each of the multiple output signals is detected after one of the first refocusing pulses and prior to a corresponding one of the second refocusing pulses.
9 . The method of claim 8 , wherein the first refocusing pulses comprise a third phase ϕ 3 , wherein the second refocusing pulses comprise a fourth phase ϕ 4 , wherein the third phase ϕ3 equals the first phase ϕ 1 plus or minus 90°, and wherein the fourth phase ϕ 4 equals the third phase ϕ 3 plus or minus 90°.
10 . The method of claim 9 , wherein the first preparation pulse comprises a fifth phase ϕ 5 , wherein the second preparation pulse comprises a sixth phase ϕ 6 , wherein the third preparation pulse comprises a seventh phase ϕ 7 , wherein the fifth phase ϕ 5 equals the first phase ϕ 1 plus or minus 90°, wherein the sixth phase ϕ 6 equals the fifth phase ϕ 5 plus or minus 90°, and wherein the seventh phase ϕ 7 equals the fifth phase ϕ 5 plus 180°.
11 . The method of claim 9 , wherein the preparation radio frequency pulse sequence is configured for diffusion weighted imaging, the method further comprising:
transmitting a gradient sequence to a gradient coil assembly configured to modify the magnetic field projected along the longitudinal axis, wherein the gradient sequence comprises:
a first diffusion gradient after the first preparation pulse and prior to the second preparation pulse of the preparation radio frequency pulse sequence;
a second diffusion gradient after the second preparation pulse and prior to the third preparation pulse of the preparation radio frequency pulse sequence.
12 . The method of claim 2 , wherein projecting a magnetic field along a longitudinal axis and toward an object of interest located within a field of view comprises projecting a low-field strength magnetic field.
13 . A system, comprising:
an array of magnets configured to generate a low-field strength magnetic field toward an object of interest located within a field of view;
a radio frequency coil assembly configured to selectively excite magnetization in the object of interest in the field of view;
a control circuit comprising a processor and a memory, wherein the memory stores instructions executable by the processor to:
transmit a preparation radio frequency pulse sequence to the radio frequency coil assembly, wherein the preparation radio frequency pulse sequence comprises:
a first preparation pulse that is frequency swept across the frequency offset range at the first rate, wherein the first preparation pulse is a 90 pulse and is the same duration as the excitation pulse;
a second preparation pulse that is frequency swept across the frequency offset range at the second rate, wherein the second preparation pulse is a 1800 pulse and is half the duration as the excitation pulse; and
a third preparation pulse that is frequency swept across the frequency offset range at the first rate, wherein the third preparation pulse is a 90° pulse and is the same duration as the excitation pulse; and
transmit a primary radio frequency pulse sequence to the radio frequency coil assembly, wherein the primary radio frequency pulse sequence comprises:
an excitation pulse that is frequency swept across a frequency offset range at a first rate, wherein the excitation pulse is a 90° pulse; and
a series of refocusing pulses following the excitation pulse, wherein each of the refocusing pulses are frequency swept across the frequency offset range at a second rate that is twice the first rate, and wherein each of the refocusing pulses are 180° pulses and are half the duration of the excitation pulse; and
receive an output signal detected by the radio frequency coil assembly intermediate two of the refocusing pulses.
14 . The system of claim 13 , wherein the primary radio frequency pulse sequence further comprises a recovery pulse following the series of refocusing pulses, wherein the recovery pulse is frequency swept across the frequency offset range at the first rate, and wherein the recovery pulse is a 90° pulse and is the same duration as the excitation pulse.
15 . The system of claim 14 , wherein the excitation pulse comprises a first phase ϕ 1 , wherein the recovery pulse comprises a second phase ϕ 2 , and wherein the second phase ϕ 2 equals the first phase ϕ 1 plus 180°.
16 . The system of claim 15 , wherein the series of refocusing pulses comprises sequentially repeating a first refocusing pulse and a second refocusing pulse, wherein the memory stores instructions executable by the processor to receive multiple output signals from the radio frequency coil assembly, and wherein each of the multiple output signals is received intermediate one of the first refocusing pulses and one of the second refocusing pulses.
17 . The system of claim 16 , wherein the first refocusing pulses comprise a third phase ϕ 3 , wherein the second refocusing pulses comprise a fourth phase ϕ 4 , wherein the first preparation pulse comprises a fifth phase ϕ 5 , wherein the second preparation pulse comprises a sixth phase ϕ 6 , wherein the third preparation pulse comprises a seventh phase ϕ 7 , wherein the third phase ϕ 3 equals the first phase ϕ 2 plus or minus 90°, wherein the fourth phase ϕ 4 equals the third phase ϕ 3 plus or minus 90°, wherein the fifth phase ϕ 5 equals the first phase ϕ 1 plus or minus 90°, wherein the sixth phase ϕ 6 equals the fifth phase ϕ 5 plus or minus 90°, and wherein the seventh phase ϕ 7 equals the fifth phase ϕ 5 plus 180°.
18 . The system of claim 17 , further comprising:
a gradient coil assembly configured to modify the low-field strength magnetic field generated by the array of magnets;
wherein the memory stores instructions executable by the processor to transmit a gradient sequence to the gradient coil assembly, wherein the gradient sequence comprises:
a first diffusion gradient after the first preparation pulse and prior to the second preparation pulse of the preparation radio frequency pulse sequence;
a second diffusion gradient after the second preparation pulse and prior to the third preparation pulse of the preparation radio frequency pulse sequence.