Granted Patent B2

US 12,558,216 · App. 17/822,903 · Granted Feb 24, 2026

Inventors: Robert James Siegel (Beverly Hills, CA); Lawrence Eric Ong (Beverly Hills, CA); Niclas Henning Zieger (Pasadena, CA)

Assignee: Cedars-Sinai Medical Center

A61F2/2403A61F2/2418A61F2/2427A61F2220/0025A61F2220/0075A61F2220/0091A61F2230/0013A61F2230/0095A61F2250/0071

Abstract

Claims (53)

1 . A method, comprising:

advancing a distal body and at least a portion of a proximal body on a delivery catheter into a first heart chamber of a heart by passing the distal body through a heart valve;

exposing the distal body and at least the portion of the proximal body outside a distal end of the delivery catheter while in the first heart chamber;

pivoting the distal body about the proximal body while maintaining contact between the proximal body and the distal body;

separating the proximal body from the distal body;

withdrawing the proximal body from the first heart chamber to a second heart chamber by passing the proximal body through the heart valve;

capturing a portion of a leaflet between the proximal body and the distal body; and

securing the proximal body to the distal body to keep the captured leaflets between the proximal body and the distal body.

2 . The method of claim 1 , wherein pivoting further comprises rotating the distal body so that a longitudinal axis of the distal body is aligned substantially perpendicular to a longitudinal axis of the proximal body.

3 . The method of claim 2 , further comprising, after rotating the distal body, aligning the proximal body so that a longitudinal axis of the proximal body is substantially parallel to the longitudinal axis of the distal body.

4 . The method of claim 1 , wherein securing further comprises cinching a tension member about the distal body and the proximal body.

5 . The method of claim 4 , wherein cinching the tension member comprises cinching a knot by advancing a first knot toward the proximal body with an elongate control body.

6 . The method of claim 5 , wherein cinching the knot further comprises:

withdrawing the elongate control body away from the proximal body to position a second knot between the elongate control body and the proximal body; and

advancing the second knot toward the first knot.

7 . The method of claim 1 , wherein securing further comprises shifting an elongate member of a connector to advance the proximal body and/or the distal body.

8 . The method of claim 7 , further comprising cinching a knot about a proximal body of the connector.

9 . The method of claim 1 , further comprising unlatching a latch mechanism disposed between coaxial shells of the delivery catheter to cause relative movement within the delivery catheter to control one or more of a change in orientation or in relative position of the distal body to the proximal body or the proximal body to the distal body.

10 . The method of claim 1 , further comprising urging a proximal portion of a prosthesis manipulator distal relative to a distal portion of the prosthesis manipulator such that the proximal portion of the prosthesis manipulator is advanced form a first pre-defined position to a second pre-defined position.

11 . A method comprising:

advancing a distal body and at least a portion of a proximal body on a delivery catheter into a first heart chamber of a heart by passing the distal body through a heart valve;

pivoting the distal body about the proximal body while maintaining contact between the proximal body and the distal body;

separating the proximal body from the distal body;

withdrawing the proximal body from the first heart chamber to a second heart chamber by passing the proximal body through the heart valve;

capturing a portion of a leaflet between the proximal body and the distal body; and

securing the proximal body to the distal body to keep the captured leaflets between the proximal body and the distal body,

wherein pivoting comprises sliding a first curved surface of the distal body over a second curved surface of the proximal body.

12 . A method comprising:

advancing a distal body and at least a portion of a proximal body on a delivery catheter into a first heart chamber of a heart by passing the distal body through a heart valve;

pivoting the distal body about the proximal body while maintaining contact between the proximal body and the distal body;

separating the proximal body from the distal body;

withdrawing the proximal body from the first heart chamber to a second heart chamber by passing the proximal body through the heart valve;

capturing a portion of a leaflet between the proximal body and the distal body; and

securing the proximal body to the distal body to keep the captured leaflets between the proximal body and the distal body,

wherein pivoting further comprises receiving a protruding portion of the proximal body into a recessed portion of the distal body.

13 . A method comprising:

advancing a distal body and at least a portion of a proximal body on a delivery catheter into a first heart chamber of a heart by passing the distal body through a heart valve;

pivoting the distal body about the proximal body while maintaining contact between the proximal body and the distal body;

separating the proximal body from the distal body;

withdrawing the proximal body from the first heart chamber to a second heart chamber by passing the proximal body through the heart valve;

capturing a portion of a leaflet between the proximal body and the distal body; and

securing the proximal body to the distal body to keep the captured leaflets between the proximal body and the distal body,

wherein securing further comprises cinching a tension member about the distal body and the proximal body,

wherein cinching the tension member comprises twisting two adjacent strands of wire about each other until a proximal portion of the wire separates from a distal portion, the distal portion securing the proximal body to the distal body.

14 . The method of claim 13 , wherein the wire comprises a fracture zone such that the proximal portion of the wire separates from the distal portion at a pre-defined location.

15 . A method comprising:

advancing a distal body and at least a portion of a proximal body on a delivery catheter into a first heart chamber of a heart by passing the distal body through a heart valve;

pivoting the distal body about the proximal body while maintaining contact between the proximal body and the distal body;

separating the proximal body from the distal body;

withdrawing the proximal body from the first heart chamber to a second heart chamber by passing the proximal body through the heart valve;

capturing a portion of a leaflet between the proximal body and the distal body; and

securing the proximal body to the distal body to keep the captured leaflets between the proximal body and the distal body, wherein capturing comprises compressing a first portion of the leaflet between a lateral stabilization member of the proximal body and a concave recess of the distal body.

16 . The method of claim 15 , wherein the lateral stabilization member comprises a convex projection of the proximal body.

Assignments (1)

Continuity (3)

References Cited (222)