IP Library › Granted Patent US 12,581,586
Granted Patent B2
US 12,581,586 · App. 18/557,687 · Granted Mar 17, 2026

Systems and methods for igniting plasma within tubes

Inventors: Andrew Pennington Myers (West Lafayette, IN); Lee Edward Organski (West Lafayette, IN); Alexey Shashurin (West Lafayette, IN); Xingxing Wang (West Lafayette, IN)
Assignee: Eli Lilly and Company
H05H1/246B29C59/005B29C59/142H05H1/2431B29C2059/145B29K2023/0633H05H2245/42
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Quick Facts
Patent No.
US 12,581,586
App. No.
18/557,687
Granted
Mar 17, 2026
Kind
B2
Abstract

A system is provided for generating plasma within narrow diameter tubes, e.g., tubes with an inner diameter of less than 1 millimeter. The system may comprise the tube, a nozzle connected to at least one end of the tube configured to supply a gas into the interior of the tube at atmospheric pressure, at least one ring-shaped anode electrode and configured to surround an outer surface of the tube, at least one ring-shaped cathode electrode spaced apart from the anode electrode along the longitudinal axis and configured to surround the outer surface of the tube, and a voltage source connected to the at least one anode electrode. When activated, the system is configured to generate an electric field between the electrodes which ignites a plasma within the gas in the interior of the tube.

Claims (25)

1 . A system for generating plasma within a polymer tube, the system comprising:

the polymer tube having a longitudinal axis and an inner diameter of less than 1 millimeter;

a nozzle connected to at least one end of the tube and configured to supply a gas into an interior of the tube;

at least one ring-shaped anode electrode positioned around an outer surface of the tube;

at least one ring-shaped cathode electrode spaced apart from the at least one anode electrode along the longitudinal axis and positioned around the outer surface of the tube; and

a voltage source connected to the at least one anode electrode, wherein the system is configured to activate the voltage source to ignite a plasma within the gas in the interior of the tube.

2 . The system of claim 1 , wherein the nozzle is configured to supply the gas into the interior of the tube at atmospheric pressure.

3 . The system of claim 1 , wherein the plasma, when ignited, forms protrusions on an interior surface of the tube to increase a hydrophilicity of the interior surface.

4 . The system of claim 1 , wherein a cross-sectional thickness of the at least one anode electrode closest to the outer surface of the tube is less than 6 mm.

5 . The system of claim 4 , wherein the cross-sectional thickness of the at least one anode electrode closest to the outer surface of the tube is less than 1 mm.

6 . The system of claim 5 , wherein the cross-sectional thickness of the at least one anode electrode closest to the outer surface of the tube is less than 0.1 mm.

7 . The system of claim 1 , wherein a cross-sectional thickness of the at least one cathode electrode closest to the outer surface of the tube is less than 6 mm.

8 . The system of claim 7 , wherein the cross-sectional thickness of the at least one cathode electrode closest to the outer surface of the tube is less than 1 mm.

9 . The system of claim 8 , wherein the cross-sectional thickness of the at least one cathode closest to the outer surface of the tube is less than 0.1 mm.

10 . The system of claim 1 , wherein:

the at least one ring-shaped cathode electrode and the at least one ring-shaped anode electrode consists essentially of metal;

a space between the outer surface of the tube and the at least one ring-shaped cathode electrode is devoid of a dielectric barrier; and

a space between the outer surface of the tube and the at least one ring-shaped anode electrode is devoid of a dielectric barrier.

11 . The system of claim 1 , wherein the tube acts as a dielectric barrier between the at least one ring-shaped cathode electrode and the gas in the interior of the tube, and as a dielectric barrier between the at least one ring-shaped anode electrode and the gas in the interior of the tube.

12 . The system of claim 1 , wherein the gas is at least one of helium and oxygen.

13 . The system of claim 1 wherein the tube is flexible, the system further comprising a spool configured to draw the flexible tube through the at least one cathode electrode and the at least one anode electrode while the voltage source is activated to form protrusions on an interior surface of the tube along a length of the flexible tube.

14 . The system of claim 1 , wherein the at least one cathode electrode comprises a plurality of cathode electrodes and the at least one anode electrodes comprises a plurality of anode electrodes, the plurality of anode electrodes and the plurality of cathode electrodes being spaced apart from one another in an alternating arrangement.

15 . The system of claim 1 , wherein the tube comprises low density polyethylene (LDPE).

16 . The system of claim 1 , wherein the gas is a first gas and the nozzle is a first nozzle, the system further comprising a second nozzle connected to at least one end of the tube and configured to supply a second gas into the interior of the tube, wherein the first nozzle and the second nozzle are individually adjustable to allow an operator to adjust a mixture of the first gas and the second gas supplied into the interior of the tube.

17 . The system of claim 1 , wherein the voltage source is configured to provide a square-wave signal to the at least one anode electrode when the voltage source is activated.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 10, 2024
From: PURDUE RESEARCH FOUNDATION
To: ELI LILLY AND COMPANY
Reel/Frame 066074/0237 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 10, 2024
From: MYERS, ANDREW PENNINGTON; ORGANSKI, LEE EDWARD; SHASHURIN, ALEXEY; WANG, XINGXING
To: PURDUE RESEARCH FOUNDATION
Reel/Frame 066074/0520 →
Continuity (2)
Provisional Application 63188615 · May 14, 2021
Related Publication 20240215143A1 · Jun 27, 2024
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