Animal treatments
Compositions and methods for the treatment and control of various conditions in an animal which comprises administering to said animal an effective amount of an immediate release composition of about 0.5% to 50% wt/wt of active ingredient together with excipients to a total of about 100%, wherein said composition dissolves in a relatively short period of time, e.g., 75 seconds or less, 5 seconds or less, or 3 seconds or less, upon administration to said animal.
1 . A method of treating a condition in an animal in need thereof, the method comprising:
determining a dose of detomidine required; and
administering orally to a pre-gastric mucosal cell of the animal a Direct Systemic Introduction (DSI) composition comprising the dose of detomidine;
wherein the DSI composition in the animal's oral cavity is dissolved in less than about 75 seconds; and
wherein the required dose of detomidine is determined by greater than 50% of the administered detomidine being detected in the animal's circulatory system via the pre-gastric mucosal cells lining the animal's alimentary canal prior to the animal's secretory stomach.
2 . The method of claim 1 , wherein the DSI composition is dissolved in less than about 30 seconds.
3 . The method of claim 1 , wherein the DSI composition provides an immediate release of detomidine.
4 . The method of claim 1 , wherein the animal is one of a human, an equine, a bovine, a canine, a feline, an ovine, a caprine, and a porcine.
5 . The method of claim 1 , wherein detomidine is present in the DSI composition in an amount ranging from about 0.5% to about 50% by weight of the overall composition.
6 . The method of claim 1 , wherein the DSI composition further comprises one or more distinct agents of an excipient, a sweetening agent, and/or a flavoring agent.
7 . The method of claim 6 , wherein the excipient includes one or more distinct agents of gelatin, mannitol, and/or another sugar alcohol.
8 . The method of claim 6 , wherein the sweetening agent includes aspartame.
9 . The method of claim 6 , wherein the flavoring agent includes one or more distinct agents of a mint flavoring agent, a peppermint flavoring agent, a fruit flavoring agent, a meat flavoring agent, and/or a fish flavoring agent.
10 . A freeze-dried Direct Systemic Introduction (DSI) composition comprising:
an effective dose of detomidine adapted to exert a therapeutic effect on an animal when administered orally and absorbed via pre-gastric mucosa of the animal to obtain greater than 50% of the administered detomidine being detected in the animal's circulatory system, wherein the detomidine is present in the DSI composition in an amount ranging from about 0.5% to about 50% by weight of the overall composition; and
wherein the DSI composition has an oral dissolution time of less than about 30 seconds.
11 . The freeze-dried DSI composition of claim 10 , further comprising one or more distinct agents as an excipient, a sweetening agent, and/or a flavoring agent.
12 . The freeze-dried DSI composition of claim 11 , wherein the excipient includes one or more distinct agents of gelatin, mannitol, and/or another sugar alcohol.
13 . The freeze-dried DSI composition of claim 11 , wherein the sweetening agent includes aspartame.
14 . The freeze-dried DSI composition of claim 11 , wherein the flavoring agent includes one or more distinct agents of a mint flavoring agent, a peppermint flavoring agent, a fruit flavoring agent, a meat flavoring agent, and/or a fish flavoring agent.
15 . The freeze-dried DSI composition of claim 10 , wherein the DSI composition provides an immediate release of the effective dose of detomidine that is absorbed via pre-gastric mucosa when administered orally.
16 . The freeze-dried DSI composition of claim 10 , wherein the effective dose of the detomidine is determined by greater than 50% of the administered detomidine is detectable within the animal's circulatory system through absorption via the pre-gastric mucosa.