IP Library › Granted Patent US 12,714,383
Granted Patent B2
US 12,714,383 · App. 18/245,151 · Granted Aug 25, 2026

Multi-modality imaging of a specimen

View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 12,714,383
App. No.
18/245,151
Filed
Mar 13, 2023
Granted
Aug 25, 2026
Kind
B2
Art Unit
2664
USPC
382/131
Assignments (5)
RELEASE OF SECURITY INTEREST RECORDED AT REEL/FRAME 065286/0407 Recorded Apr 24, 2026
From: BANK OF AMERICA, N.A., AS COLLATERAL AGENT
To: HOLOGIC, INC.; GEN-PROBE INCORPORATED; FAXITRON BIOPTICS, LLC; BIOTHERANOSTICS, INC.; GEN-PROBE PRODESSE, INC.
Reel/Frame 075457/0767 →
SECURITY INTEREST Recorded Apr 8, 2026
From: BIOTHERANOSTICS, INC.; GEN-PROBE INCORPORATED; GEN-PROBE PRODESSE, INC.; CYTYC CORPORATION; SUROS SURGICAL SYSTEMS, INC.; GYNESONICS, INC.; BOLDER SURGICAL, LLC; FAXITRON BIOPTICS, LLC; HEALTH BEACONS, INC.; HOLOGIC, INC.
To: ROYAL BANK OF CANADA, AS COLLATERAL AGENT
Reel/Frame 075462/0440 →
SECURITY INTEREST Recorded Apr 8, 2026
From: BIOTHERANOSTICS, INC.; GEN-PROBE INCORPORATED; GEN-PROBE PRODESSE, INC.; CYTYC CORPORATION; SUROS SURGICAL SYSTEMS, INC.; GYNESONICS, INC.; BOLDER SURGICAL, LLC; FAXITRON BIOPTICS, LLC; HEALTH BEACONS, INC.; HOLOGIC, INC.
To: CITIBANK, N.A., AS COLLATERAL AGENT
Reel/Frame 075926/0339 →
SECURITY INTEREST Recorded Oct 19, 2023
From: HOLOGIC, INC.; FAXITRON BIOPTICS, LLC; BIOTHERANOSTICS, INC.; GEN-PROBE INCORPORATED; GEN-PROBE PRODESSE, INC.
To: BANK OF AMERICA, N.A., AS COLLATERAL AGENT
Reel/Frame 065286/0407 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 14, 2023
From: REN, BAORUI; STEIN, JAY A.
To: HOLOGIC, INC.
Reel/Frame 062978/0037 →
Continuity (2)
Provisional Application 63082819 · Sep 24, 2020
Related Publication 20230355200A1 · Nov 9, 2023
References Cited (300)
US 4038988A · Perisse · 1977 [cited by applicant]
US 4134012A · Smallbone et al. · 1979 [cited by applicant]
US 4306570A · Matthews · 1981 [cited by applicant]
US 4549554A · Markham · 1985 [cited by applicant]
US 4658834A · Blankenship et al. · 1987 [cited by applicant]
US 4802195A · Wojcienchowski · 1989 [cited by applicant]
US 4803639A · Steele · 1989 [cited by applicant]
US 4837795A · Garrigus · 1989 [cited by applicant]
US 4852560A · Hermann, Jr. · 1989 [cited by applicant]
US 5023894A · Yamashita · 1991 [cited by applicant]
US 5023895A · McCroskey · 1991 [cited by applicant]
US 5256160A · Clement · 1993 [cited by applicant]
US 5427742A · Holland · 1995 [cited by applicant]
US 5456689A · Kresch et al. · 1995 [cited by applicant]
US 5491344A · Kenny et al. · 1996 [cited by applicant]
US 5505210A · Clement · 1996 [cited by applicant]
US 5526822A · Burbank et al. · 1996 [cited by applicant]
US 5541856A · Hammermeister · 1996 [cited by applicant]
US 5575293A · Miller et al. · 1996 [cited by applicant]
US 5609827A · Russell · 1997 [cited by applicant]
US 5754621A · Suzuki · 1998 [cited by applicant]
US 5872828A · Niklason · 1999 [cited by applicant]
US 5983125A · Alfano et al. · 1999 [cited by applicant]
US 6017316A · Ritchart et al. · 2000 [cited by applicant]
US 6032673A · Savage et al. · 2000 [cited by applicant]
US 6058159A · Conway · 2000 [cited by applicant]
US 6163590A · Wilkins · 2000 [cited by applicant]
US 6207111B1 · Weinberg · 2001 [cited by applicant]
US 6225107B1 · Nagle · 2001 [cited by applicant]
US 6234672B1 · Tomasetti et al. · 2001 [cited by applicant]
US 6322522B1 · Zimmon · 2001 [cited by applicant]
US 6403035B1 · Caratsch et al. · 2002 [cited by applicant]
US 6485436B1 · Truckai et al. · 2002 [cited by applicant]
US 6535284B1 · Hajduk et al. · 2003 [cited by applicant]
US 6646721B2 · Compter · 2003 [cited by applicant]
US 6882700B2 · Wang · 2005 [cited by applicant]
US 6899850B2 · Haywood · 2005 [cited by applicant]
US 6999554B2 · Mertelmeier · 2006 [cited by applicant]
US 7110490B2 · Eberhard et al. · 2006 [cited by applicant]
US 7166113B2 · Arambula · 2007 [cited by applicant]
US 7175612B2 · Felix et al. · 2007 [cited by applicant]
US 7298816B2 · Moore · 2007 [cited by applicant]
US 7397894B2 · Nakai · 2008 [cited by applicant]
US 7453979B2 · Sendai · 2008 [cited by applicant]
US 7546925B1 · Zuk, Jr. · 2009 [cited by applicant]
US 7573977B2 · Tsujita · 2009 [cited by applicant]
US 7616801B2 · Gkanatsios et al. · 2009 [cited by applicant]
US 7662109B2 · Hibner · 2010 [cited by applicant]
US 7692144B2 · Watanabe · 2010 [cited by applicant]
US 7697661B2 · Souchay · 2010 [cited by applicant]
US 7708462B2 · Fujiwara · 2010 [cited by applicant]
US 7715523B2 · Lafferty · 2010 [cited by applicant]
US 7753857B2 · Hibner · 2010 [cited by applicant]
US 7758601B2 · Heywang-Koebrunner et al. · 2010 [cited by applicant]
US 7817773B2 · Stanton · 2010 [cited by applicant]
US 7826588B2 · Eliasson · 2010 [cited by applicant]
US 7835490B2 · Ramsauer · 2010 [cited by applicant]
US 7854705B2 · Pawluczyk et al. · 2010 [cited by applicant]
US 7856081B2 · Peschmann · 2010 [cited by applicant]
US 7858038B2 · Andreyko et al. · 2010 [cited by applicant]
US 7867173B2 · Hibner et al. · 2011 [cited by applicant]
US 7869563B2 · DeFreitas et al. · 2011 [cited by applicant]
US 7881427B2 · Kalender et al. · 2011 [cited by applicant]
US 7881428B2 · Jing et al. · 2011 [cited by applicant]
US 7885378B2 · Kopans · 2011 [cited by applicant]
US 7972062B2 · Nicolosi · 2011 [cited by applicant]
US 8038347B2 · Manak · 2011 [cited by applicant]
US 8038627B2 · Hibner · 2011 [cited by applicant]
US 8050735B2 · Feke · 2011 [cited by applicant]
US 8052616B2 · Andrisek et al. · 2011 [cited by applicant]
US 8162140B2 · Hansen · 2012 [cited by applicant]
US 8177728B2 · Hibner et al. · 2012 [cited by applicant]
US 8213570B2 · Panesar · 2012 [cited by applicant]
US 8217357B2 · Stein et al. · 2012 [cited by applicant]
US 8235913B2 · Hibner et al. · 2012 [cited by applicant]
US 8284896B2 · Singh · 2012 [cited by applicant]
US 8532745B2 · DeFreitas et al. · 2013 [cited by applicant]
US 8553837B2 · Johansson · 2013 [cited by applicant]
US 8565374B2 · DeFreitas et al. · 2013 [cited by applicant]
US 8702623B2 · Parihar · 2014 [cited by applicant]
US 8741232B2 · Baysal · 2014 [cited by applicant]
US 8764679B2 · Miller et al. · 2014 [cited by applicant]
US 8787522B2 · Smith et al. · 2014 [cited by applicant]
US 8838207B2 · Nakayama et al. · 2014 [cited by applicant]
US 8873716B2 · Ren et al. · 2014 [cited by applicant]
US 8911381B2 · Hibner et al. · 2014 [cited by applicant]
US 8923603B2 · Weston · 2014 [cited by applicant]
US 8956306B2 · Hibner · 2015 [cited by applicant]
US 8971484B2 · Beckmann · 2015 [cited by applicant]
US 8983030B2 · Ookawa · 2015 [cited by applicant]
US 9020579B2 · Smith et al. · 2015 [cited by applicant]
US 9066706B2 · DeFreitas et al. · 2015 [cited by applicant]
US 9068920B2 · Churilla · 2015 [cited by applicant]
US 9129715B2 · Adler · 2015 [cited by applicant]
US 9188696B2 · Schafer · 2015 [cited by applicant]
US 9234855B2 · Watanabe · 2016 [cited by applicant]
US 9277895B2 · Hara · 2016 [cited by applicant]
US 9322790B2 · Ookawa · 2016 [cited by applicant]
US 9326755B2 · Fiebig · 2016 [cited by applicant]
US 9329139B2 · Itou · 2016 [cited by applicant]
US 9341546B2 · Stuke · 2016 [cited by applicant]
US 9347894B2 · Sims · 2016 [cited by applicant]
US 9492130B2 · Flagle et al. · 2016 [cited by applicant]
US 9498175B2 · Stein et al. · 2016 [cited by applicant]
US 9549709B2 · DeFreitas et al. · 2017 [cited by applicant]
US 9557281B2 · Badawi et al. · 2017 [cited by applicant]
US 9642581B2 · Lowe · 2017 [cited by applicant]
US 9668711B2 · Smith et al. · 2017 [cited by applicant]
US 9733167B2 · Wismueller · 2017 [cited by applicant]
US 9750484B2 · Finke et al. · 2017 [cited by applicant]
US 9861327B2 · Yasuda et al. · 2018 [cited by applicant]
US 9865424B2 · Ikeda · 2018 [cited by applicant]
US 9901320B2 · DeFreitas et al. · 2018 [cited by applicant]
US 9943850B2 · Purdy · 2018 [cited by applicant]
US 9953799B2 · Hakoda · 2018 [cited by applicant]
US 10008298B2 · King · 2018 [cited by applicant]
US 10010296B2 · Basu · 2018 [cited by applicant]
US 10028717B2 · Lou · 2018 [cited by examiner]
US 10078093B2 · Flagle · 2018 [cited by applicant]
US 10098216B2 · Kabumoto · 2018 [cited by applicant]
US 10105709B2 · Purdy · 2018 [cited by applicant]
US 10145806B2 · Tanaka · 2018 [cited by applicant]
US 10190997B2 · Aoki · 2019 [cited by applicant]
US 10194875B2 · DeFreitas et al. · 2019 [cited by applicant]
US 10201331B2 · Fleming · 2019 [cited by applicant]
US 10322412B2 · Purdy · 2019 [cited by applicant]
US 10393678B2 · Watanabe · 2019 [cited by applicant]
US 10488351B2 · Butani · 2019 [cited by applicant]
US 10489964B2 · Wang · 2019 [cited by applicant]
US 10542951B2 · Klausz et al. · 2020 [cited by applicant]
US 10561387B2 · Smith et al. · 2020 [cited by applicant]
US 10631809B2 · Noh · 2020 [cited by applicant]
US 10646178B2 · Butani · 2020 [cited by applicant]
US 10652990B2 · Butani · 2020 [cited by applicant]
US 10670545B2 · Butani · 2020 [cited by applicant]
US 10705030B2 · Watanabe · 2020 [cited by applicant]
US 10709396B2 · Lou · 2020 [cited by applicant]
US 10729399B2 · Butani · 2020 [cited by applicant]
US 10729403B2 · DeFreitas et al. · 2020 [cited by applicant]
US 10753836B2 · O'Driscoll · 2020 [cited by applicant]
US 10792003B2 · Smith et al. · 2020 [cited by applicant]
US 10809208B2 · Yashima · 2020 [cited by applicant]
US 10827989B2 · Vancamberg et al. · 2020 [cited by applicant]
US 10830712B2 · Butani · 2020 [cited by applicant]
US 10905385B2 · DeFreitas et al. · 2021 [cited by applicant]
US 10921265B2 · Butani · 2021 [cited by applicant]
US 10937161B2 · Butani · 2021 [cited by applicant]
US 11020066B2 · Butani · 2021 [cited by applicant]
US 11039803B1 · Butani · 2021 [cited by applicant]
US 11083426B2 · DeFreitas · 2021 [cited by applicant]
US 11162909B2 · Butani · 2021 [cited by applicant]
US 11191502B2 · Smith et al. · 2021 [cited by applicant]
US 11207036B2 · Butani · 2021 [cited by applicant]
US 11246551B2 · Butani · 2022 [cited by applicant]
US 11317881B2 · Purdy et al. · 2022 [cited by applicant]
US 11358149B2 · Purdy · 2022 [cited by applicant]
US 11478206B2 · Smith et al. · 2022 [cited by applicant]
US 11566981B2 · O'Driscoll · 2023 [cited by applicant]
US 11617548B2 · DeFreitas et al. · 2023 [cited by applicant]
US 11730434B2 · DeFreitas · 2023 [cited by applicant]
US 11877877B2 · Purdy · 2024 [cited by applicant]
US 20020007188A1 · Arambula · 2002 [cited by applicant]
US 20020145722A1 · Compter · 2002 [cited by applicant]
US 20020193656A1 · Ravins et al. · 2002 [cited by applicant]
US 20030087423A1 · Haywood · 2003 [cited by applicant]
US 20030216730A1 · Barry et al. · 2003 [cited by applicant]
US 20040022350A1 · Gregerson et al. · 2004 [cited by applicant]
US 20040174031A1 · Rasmussen · 2004 [cited by applicant]
US 20040218716A1 · Freifeld · 2004 [cited by applicant]
US 20050051723A1 · Neagle et al. · 2005 [cited by applicant]
US 20050065453A1 · Shabaz et al. · 2005 [cited by applicant]
US 20050112034A1 · McCormick · 2005 [cited by applicant]
US 20050124913A1 · Damarati · 2005 [cited by applicant]
US 20050148842A1 · Wang · 2005 [cited by applicant]
US 20060074343A1 · Hibner · 2006 [cited by applicant]
US 20060116603A1 · Shibazaki et al. · 2006 [cited by applicant]
US 20060173266A1 · Pawluczyk et al. · 2006 [cited by applicant]
US 20070106176A1 · Mark et al. · 2007 [cited by applicant]
US 20070116612A1 · Williamson · 2007 [cited by applicant]
US 20070166834A1 · Williamson, IV et al. · 2007 [cited by applicant]
US 20070237684A1 · Hansen · 2007 [cited by applicant]
US 20070239067A1 · Hibner et al. · 2007 [cited by applicant]
US 20070270714A1 · Cushner et al. · 2007 [cited by applicant]
US 20080004545A1 · Garrison · 2008 [cited by applicant]
US 20080082021A1 · Ichikawa · 2008 [cited by applicant]
US 20080132805A1 · Heywang-Koebrunner et al. · 2008 [cited by applicant]
US 20080214955A1 · Speeg et al. · 2008 [cited by applicant]
US 20080221480A1 · Hibner et al. · 2008 [cited by applicant]
US 20080228103A1 · Ritchie et al. · 2008 [cited by applicant]
US 20080249434A1 · Hashimshony et al. · 2008 [cited by applicant]
US 20090088663A1 · Miller et al. · 2009 [cited by applicant]
US 20090088666A1 · Miller et al. · 2009 [cited by applicant]
US 20090131818A1 · Speeg et al. · 2009 [cited by applicant]
US 20090131820A1 · Speeg · 2009 [cited by applicant]
US 20090131823A1 · Andreyko et al. · 2009 [cited by applicant]
US 20090171243A1 · Hibner et al. · 2009 [cited by applicant]
US 20090171244A1 · Ning · 2009 [cited by applicant]
US 20090213987A1 · Stein · 2009 [cited by applicant]
US 20100080346A1 · Kalender et al. · 2010 [cited by applicant]
US 20100081964A1 · Mark · 2010 [cited by applicant]
US 20100152611A1 · Parihar · 2010 [cited by applicant]
US 20100160824A1 · Parihar · 2010 [cited by applicant]
US 20100160826A1 · Parihar · 2010 [cited by applicant]
US 20100191145A1 · Lafferty · 2010 [cited by applicant]
US 20100317997A1 · Hibner · 2010 [cited by applicant]
US 20110123074A1 · Nie · 2011 [cited by applicant]
US 20110142201A1 · Eberhard et al. · 2011 [cited by applicant]
US 20110285837A1 · Bello · 2011 [cited by applicant]
US 20120014504A1 · Jang · 2012 [cited by examiner]
US 20120051514A1 · Sims et al. · 2012 [cited by applicant]
US 20120053484A1 · Parks · 2012 [cited by applicant]
US 20120116246A1 · Hibner · 2012 [cited by applicant]
US 20120123295A1 · Sanbuichi · 2012 [cited by applicant]
US 20120245485A1 · Hibner · 2012 [cited by applicant]
US 20130053724A1 · Fiebig · 2013 [cited by applicant]
US 20130231585A1 · Flagle · 2013 [cited by applicant]
US 20130280752A1 · Ozcan · 2013 [cited by applicant]
US 20140016744A1 · Muenker · 2014 [cited by applicant]
US 20140039343A1 · Mescher · 2014 [cited by applicant]
US 20140051986A1 · Zhao et al. · 2014 [cited by applicant]
US 20140065656A1 · Baysal · 2014 [cited by applicant]
US 20140072104A1 · Jacobsen et al. · 2014 [cited by applicant]
US 20140198893A1 · Badawi · 2014 [cited by examiner]
US 20140257135A1 · DeFreitas · 2014 [cited by applicant]
US 20140276209A1 · Hibner · 2014 [cited by applicant]
US 20150083893A1 · Wismueller · 2015 [cited by examiner]
US 20150131773A1 · Lowe et al. · 2015 [cited by applicant]
US 20150209017A1 · Fleming · 2015 [cited by applicant]
US 20160211045A1 · Jeon et al. · 2016 [cited by applicant]
US 20170131311A1 · Flagle · 2017 [cited by applicant]
US 20170309063A1 · Wang · 2017 [cited by applicant]
US 20170336706A1 · Wang · 2017 [cited by applicant]
US 20180045660A1 · Yashima · 2018 [cited by applicant]
US 20180168523A1 · Vancamberg et al. · 2018 [cited by applicant]
US 20180249985A1 · DeFreitas et al. · 2018 [cited by applicant]
US 20190054217A1 · Axon · 2019 [cited by applicant]
US 20190072463A1 · O'Driscoll · 2019 [cited by applicant]
US 20190130563A1 · Vecchio et al. · 2019 [cited by applicant]
US 20190167869A1 · Willard · 2019 [cited by applicant]
US 20190285558A1 · DeFreitas · 2019 [cited by applicant]
US 20190346471A1 · Flagle · 2019 [cited by applicant]
US 20200029927A1 · Wilson et al. · 2020 [cited by applicant]
US 20200061622A1 · Purdy · 2020 [cited by applicant]
US 20200085393A1 · Zhang et al. · 2020 [cited by applicant]
US 20200187923A1 · Safir · 2020 [cited by applicant]
US 20200268331A1 · Purdy · 2020 [cited by applicant]
US 20200352543A1 · DeFreitas et al. · 2020 [cited by applicant]
US 20200386657A1 · O'Driscoll · 2020 [cited by applicant]
US 20210259649A1 · Milioni De Carvalho · 2021 [cited by applicant]
US 20220015729A1 · Purdy et al. · 2022 [cited by applicant]
US 20220015731A1 · Liu · 2022 [cited by applicant]
US 20220039766A1 · DeFreitas · 2022 [cited by applicant]
US 20220071583A1 · Chmeissani · 2022 [cited by applicant]
US 20220110597A1 · Chen · 2022 [cited by applicant]
US 20220133252A1 · Smith et al. · 2022 [cited by applicant]
US 20220296189A1 · Purdy · 2022 [cited by examiner]
US 20220331808A1 · Purdy · 2022 [cited by applicant]
US 20230012310A1 · Stango · 2023 [cited by applicant]
US 20230014922A1 · DeFreitas · 2023 [cited by applicant]
US 20230121010A1 · Smith et al. · 2023 [cited by applicant]
US 20230136395A1 · Chen · 2023 [cited by applicant]
US 20230172572A1 · Bumdra · 2023 [cited by applicant]
US 20230204473A1 · O'Driscoll · 2023 [cited by applicant]
US 20230404499A1 · DeFreitas · 2023 [cited by applicant]
US 20240016461A1 · Wolff · 2024 [cited by applicant]
US 20240315676A1 · Chen · 2024 [cited by applicant]
US 20240359187A1 · Purdy · 2024 [cited by applicant]
US 20250072856A1 · Bundra · 2025 [cited by applicant]
DE 202019106995 · 2020 [cited by applicant]
EP 2277445 · 2011 [cited by applicant]
EP 2007287 · 2016 [cited by applicant]
EP 3143937 · 2017 [cited by applicant]
GB 2018601 · 1979 [cited by applicant]
JP 2006346179 · 2006 [cited by applicant]
JP 2014526937 · 2014 [cited by applicant]
JP 2015085056 · 2015 [cited by applicant]
JP 2015520402 · 2015 [cited by applicant]
JP 2016154878 · 2016 [cited by applicant]
JP 2017099928 · 2017 [cited by applicant]
JP 6320717B2 · 2018 [cited by applicant]
WO 8101363 · 1981 [cited by applicant]
WO 2007021905 · 2007 [cited by applicant]
WO 2008025146 · 2008 [cited by applicant]
WO 2009120206 · 2009 [cited by applicant]
WO 2010028208 · 2010 [cited by applicant]
WO 2011140374 · 2011 [cited by applicant]
WO 2012074885 · 2012 [cited by applicant]
WO 2013166497 · 2013 [cited by applicant]
WO 2017060726 · 2017 [cited by applicant]
WO 2018183086 · 2018 [cited by applicant]
WO 2018204710 · 2018 [cited by applicant]
WO 2019051496 · 2019 [cited by applicant]
WO 2019085342 · 2019 [cited by applicant]
WO 2019216766 · 2019 [cited by applicant]
WO 2020106888 · 2020 [cited by applicant]
WO 2021202455 · 2021 [cited by applicant]
International Search Report and Written Opinion for PCT/US2021/048726 (Dec. 23, 2021). [cited by applicant]
Watanabe, M. et al., “The quantitative analysis of thin specimens: a review of progress from the Cliff-Lorimer to the new zeta-factor methods”, Journal of Microscopy, vol. 221, No. 2, Feb. 1, 2006, p. 91. [cited by applicant]
Basak Erguvan-Dogan et al., “Specimen Radiography in Confirmation of MRI-Guided Needle Localization and Surgical Excision of Breast Lesions”, American Journal of Roentgenology, American Roentgen Ray Society, vol. 187, N… [cited by applicant]
PCT International Preliminary Report on Patentability in International Application PCT/US2021/048726, mailed Apr. 6, 2023, 9 pages. [cited by applicant]