IP Library › Granted Patent US 12,742,749
Granted Patent B2
US 12,742,749 · App. 18/762,515 · Granted Sep 22, 2026

Systems, sensor assemblies and methods

Inventors: Alfonso Berduque (Crusheen, IE); Alan O'Donnell (Castletroy, IE); Simone Mullins (Limerick, IE); Joyce Wu (Somerville, MA); Junfei Xia (Andover, MA); Richard Doyle (Churchtown, IE)
Assignee: Analog Devices International Unlimited Company
G01N27/4163
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Quick Facts
Patent No.
US 12,742,749
App. No.
18/762,515
Granted
Sep 22, 2026
Kind
B2
Abstract

The present disclosure provides methods and systems for reducing interference by one or more bubbles in a sensing assembly. Bubble prevention arrangements can use surfaces located in a fluid channel to provide surfaces with higher affinity for bubbles relative to the other surfaces so that the surface retains one or more bubbles within a bubble collection region; and/or to divert at least a portion of any bubbles passing through an opening in the fluid channel. Additionally or alternatively, bubble prevention arrangements comprise an agitation device configured to agitate liquid within the fluid channel. Additionally or alternatively, bubble prevention arrangements are configured to displace one or more bubbles in a region on or adjacent the sensing surface so as to reduce interference of one or more bubbles on the sensing surface.

Claims (40)

1 . A system for reducing interference by one or more bubbles in a liquid in a sensing assembly, the system comprising:

a sensing assembly comprising a sensing surface, the sensing surface being configured to receive the liquid and the sensing assembly configured to provide a measurement signal indicative of an interaction of the sensing surface with the liquid;

a fluid channel defining a flow path configured to provide liquid to the sensing surface, the fluid channel comprising a first surface; and

a bubble prevention arrangement arranged in and/or fluidly connected to the fluid channel for preventing one or more bubbles from interfering with the sensing surface, the bubble prevention arrangement comprising a bubble collection region in which one or more bubbles can be collected,

wherein the bubble prevention arrangement comprises a second surface located in the fluid channel; and

wherein:

the bubble collection region comprises the second surface and the second surface has a higher affinity for bubbles relative to the first surface so that the second surface retains one or more bubbles within the bubble collection region; and/or

the bubble collection region is separate to and fluidly connected to the fluid channel via an opening in the fluid channel and the second surface is configured to divert at least a portion of any bubbles passing through the fluid channel to the opening.

2 . The system of claim 1 , wherein the bubble collection region is separate to and fluidly connected to the fluid channel via an opening in the fluid channel and the second surface is configured to divert at least a portion of any bubbles passing through the fluid channel to the opening; and

wherein (i) the second surface is shaped or arranged so as to intercept and redirect at least a portion of any bubbles in the liquid through the opening and/or (ii) the surface properties of the second surface are selected to attract bubbles and/or cause bubbles to adhere thereto so that these can be diverted to the opening.

3 . The system of claim 1 , wherein the surface energy of the second surface is lower than the surface energy of the first surface so as to provide the higher affinity.

4 . The system of claim 1 , wherein the bubble collection region is separate to and fluidly connected to the fluid channel via an opening in the fluid channel and the second surface is configured to divert at least a portion of bubbles passing through the fluid channel to the opening; and

wherein (i) the second surface is shaped to intercept at least a portion of any bubbles in the liquid present in the fluid channel and divert the bubbles to and through the opening and/or (ii) the surface properties of the second surface are selected so that second surface attracts bubbles from the liquid to the second surface and/or causes bubbles to adhere to the second surface so as to divert at least a portion of bubbles from the liquid to the opening.

5 . The system of claim 4 , wherein the second surface at least partly extends around the opening.

6 . The system of claim 1 , wherein the system further comprises a modification unit configured to modify the affinity of the sensing surface and/or the second surface to bubbles in the liquid.

7 . A system for reducing interference by one or more bubbles in a liquid in a sensing assembly, the system comprising:

a sensing assembly comprising a sensing surface, the sensing surface being configured to receive the liquid and the sensing assembly configured to provide a measurement signal indicative of an interaction of the sensing surface with the liquid;

a fluid channel defining a flow path configured to provide liquid to the sensing surface; and

a bubble collection region in which one or more bubbles can be collected; and

a bubble prevention arrangement comprising an agitation device configured to agitate liquid within the fluid channel so as to:

cause dissolved gases in the liquid in the fluid channel to form bubbles, wherein the agitation device is arranged so that at least a portion of the formed bubbles can be collected in the bubble collection region; and/or

direct one or more bubbles in the liquid to the bubble collection region.

8 . The system of claim 7 , wherein the agitation device comprises at least one of: a sound-wave generating device configured to cause agitation of the liquid within the fluid channel, a force generating device configured to provide a force to the fluid channel to agitate liquid within the fluid channel; and an actuator comprising a moveable element configured to cause agitation of the liquid within the fluid channel.

9 . The system of claim 8 , wherein the agitation device comprises an actuator comprising a moveable element configured to cause agitation of the liquid within the fluid channel and wherein the actuator is selected from a piezoelectric actuator, an electroactive polymer actuator and a thermal actuator.

10 . The system of claim 9 , wherein the moveable element is located within the fluid channel or is configured to move a part of the fluid channel so as to cause agitation of the liquid.

11 . The system of claim 10 , wherein the moveable element is a piezoelectric material or electroactive polymer material; or

wherein the actuator comprises an actuator part comprising a piezoelectric material or an electroactive polymer material and the actuator part is configured to cause movement of the moveable element.

12 . The system of claim 7 , wherein the bubble collection region comprises a trap channel configured to draw a bubble into the trap channel and retain the bubble therein.

13 . The system of claim 7 , wherein the bubble collection region is separate to and fluidly connected to the fluid channel via an opening in the fluid channel; and wherein the agitation device is configured to divert at least a portion of bubbles passing through the fluid channel to the opening.

14 . A method for reducing the interference of bubbles in a system for determining a property of a liquid, the method comprising:

providing a system according to claim 1 ;

providing a liquid to the sensing surface;

removing bubbles and/or dissolved gas from the liquid using the bubble prevention arrangement; and

determining a property of the liquid using the sensing assembly.

15 . The method of claim 14 , further comprising pre-treating the liquid prior to determining a property of the liquid so as to reduce the number of bubbles in the liquid and/or to reduce the likelihood of bubble formation prior to the liquid being provided to the sensing assembly.

16 . The method of claim 15 , wherein the step of pre-treating comprises at least one of applying a vacuum to the liquid, applying pressure to the liquid, and/or providing a gas scavenger to the liquid.

17 . The method of claim 14 , further comprising determining a first property relating to the number of bubbles in the liquid; and wherein the step of removing bubbles and/or dissolved gas from the liquid using the bubble prevention arrangement is carried out based on the determined first property.

18 . The method of claim 14 , wherein the liquid is charged and wherein the method further comprises applying an opposing charge to the sensing surface so as to cause the liquid to cover the sensing surface.

19 . A computer program comprising computer program code configured, when said computer program is run on one or more physical computing devices, to cause said one or more physical computing devices to implement the method according to claim 14 .

20 . One or more non-transitory computer readable media having a computer program stored thereon, the computer program comprising computer program code which is configured, when said computer program is run on one or more physical computing devices, to cause one or more physical computing devices to implement the method according to claim 14 .

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 24, 2025
From: WU, JOYCE; ODONNELL, ALAN; XIA, JUNFEI; MULLINS, SIMONE; DOYLE, RICHARD; BERDUQUE, ALFONSO
To: ANALOG DEVICES INTERNATIONAL UNLIMITED COMPANY
Reel/Frame 072355/0576 →
Continuity (2)
Provisional Application 63512198 · Jul 6, 2023
Related Publication 20250012759A1 · Jan 9, 2025
References Cited (59)
US 3675501A · De Kanter · 1972 [cited by applicant]
US 4267509A · Graham · 1981 [cited by applicant]
US 6030118A · Schneider et al. · 2000 [cited by applicant]
US 7048890B2 · Coehoorn et al. · 2006 [cited by applicant]
US 7547415B2 · Hataoka et al. · 2009 [cited by applicant]
US 7609054B2 · Tondra et al. · 2009 [cited by applicant]
US 9513246B2 · O'Donnell et al. · 2016 [cited by applicant]
US 9841421B2 · Dittmer et al. · 2017 [cited by applicant]
US 10357771B2 · Bharadwaj et al. · 2019 [cited by applicant]
US 11061086B2 · O'Donnell et al. · 2021 [cited by applicant]
US 11525820B2 · Meier et al. · 2022 [cited by applicant]
US 11666913B2 · Beaumont et al. · 2023 [cited by applicant]
US 11788646B1 · Huff · 2023 [cited by applicant]
US 20030000833A1 · Mansouri et al. · 2003 [cited by applicant]
US 20080317632A1 · Shimasaki · 2008 [cited by examiner]
US 20090026080A1 · Han et al. · 2009 [cited by applicant]
US 20100089133A1 · Yamasaki et al. · 2010 [cited by applicant]
US 20120079981A1 · Huffman et al. · 2012 [cited by applicant]
US 20130085687A1 · Danov et al. · 2013 [cited by applicant]
US 20130105581A1 · Kwon et al. · 2013 [cited by applicant]
US 20130335492A1 · Edombingo · 2013 [cited by examiner]
US 20140026649A1 · O'Donnell et al. · 2014 [cited by applicant]
US 20140273187A1 · Johnson et al. · 2014 [cited by applicant]
US 20140374854A1 · Xue · 2014 [cited by applicant]
US 20180038737A1 · Hedlund et al. · 2018 [cited by applicant]
US 20200072783A1 · Berney et al. · 2020 [cited by applicant]
US 20210060566A1 · Corey · 2021 [cited by examiner]
US 20210325484A1 · Pellegrino et al. · 2021 [cited by applicant]
US 20220219171A1 · Siltanen et al. · 2022 [cited by applicant]
US 20220362778A1 · Foster et al. · 2022 [cited by applicant]
US 20220371019A1 · Mei et al. · 2022 [cited by applicant]
US 20230085052A1 · Klein et al. · 2023 [cited by applicant]
US 20230098962A1 · O'Donnell et al. · 2023 [cited by applicant]
US 20230152166A1 · O'Donnell et al. · 2023 [cited by applicant]
US 20250012759A1 · Berduque · 2025 [cited by examiner]
AT 511171A1 · 2012 [cited by applicant]
CN 114152593A · 2022 [cited by applicant]
EP 1855114A1 · 2007 [cited by applicant]
EP 2413128A1 · 2012 [cited by applicant]
EP 3896470A1 · 2021 [cited by applicant]
JP 2007245038A · 2007 [cited by applicant]
JP 5261124B2 · 2013 [cited by applicant]
KR 20190070635A · 2019 [cited by applicant]
KR 102039230B1 · 2019 [cited by examiner]
WO 2012013814A1 · 2012 [cited by applicant]
WO WO2016143278A1 · 2016 [cited by examiner]
Bubbles no more in plane trapping and removal of bubbles in microfluidic devices (Lab on Chip Dec. 2011). [cited by applicant]
Cilia Metasurfaces for electronically programmable microfluidic manipulation (Nature vol. 605 May 25, 2022). [cited by applicant]
Wataru Iwasaki et al., Development of a Thermoresponsive Valve Membrane for Microfluic Paper-based Analytical Device. [cited by applicant]
Mohsen Annabestani, et al., Ionic Electro Active Polymer-Based Soft Actuators and their Applications in Mircrofluidic Micropumps, Microvalves, and Micromixers: A Review. [cited by applicant]
Edwin W.H.Jager et al., Electroactive Surfaces based on Conducting Polymers for Controlling Cell Adhesion, Signaling, and Proliferation. [cited by applicant]
Y.Lee, et al., Flow Characteristics of Hydrophilic/Hydrophobic Capillaries Considering Surface Tension. [cited by applicant]
Philippe Dubois et al., “Microactuators based on ION-Implanted Dielectric Electroactive Polymer Membranes (EAP)”. [cited by applicant]
T.Zhang et al., Microfluidic Valves based on TiO2 Coating with Tunable Surface Wettability between Super Hydrophilic and Super Hydrophobic. [cited by applicant]
Extended European Search Report issued in corresponding European Application No. 24185018 dated Mar. 31, 2025. [cited by applicant]
Partial Search Report issued in corresponding European Application No. 24185018 dated Jan. 8, 2025. [cited by applicant]
Chung et al., “On-chip creation and elimination of microbubbles for a micro-object manipulator”, J. Micromech. Microeng., vol. 18, 2008, pp. 1-13. [cited by applicant]
Extended European Search Report received for European Application No. 24185020.5, mailed on Nov. 15, 2024, 9 pages. [cited by applicant]
Satoh et al., “On-chip microfluidic transport and bio/chemical sensing based on electrochemical bubble formation”, Sensors and Actuators B, vol. 123, 2007, pp. 1153-1160. [cited by applicant]