Granted Patent B2

US 7,968,689 · App. 12/198,817 · Granted Jun 28, 2011

Assignee: Human Genome Sciences, Inc.

Abstract

Claims (35)

1. An isolated antibody or fragment thereof that binds specifically to an isolated HSDEK49 polypeptide selected from the group consisting of:

(a) a polypeptide consisting of amino acid residues 1 to 399 of SEQ ID NO:1373;

(b) a polypeptide consisting of amino acid residues 2 to 399 of SEQ ID NO:1373;

(c) a polypeptide consisting of amino acid residues 20 to 399 of SEQ ID NO:1373;

(d) a polypeptide consisting of the amino acid sequence of the full-length polypeptide, which amino acid sequence is encoded by the cDNA contained in ATCC™ Deposit No:209603, which was deposited on Jan. 29, 1998;

(e) a polypeptide consisting of the amino acid sequence of the HSDEK49 polypeptide, excluding the N-terminal methionine residue, which amino acid sequence is encoded by a polynucleotide contained within the cDNA contained in ATCC™ Deposit No:209603, which was deposited on Jan. 29, 1998;

(f) a polypeptide consisting of the amino acid sequence of the HSDEK49 polypeptide, excluding the leader sequence of the polypeptide, which amino acid sequence is encoded by a polynucleotide contained within the cDNA contained in ATCC™ Deposit No:209603, which was deposited on Jan. 29, 1998;

(g) an extracellular domain of the polypeptide consisting of amino acid residues 1 to 399 of SEQ ID NO:1373; and

(h) an extracellular domain of the polypeptide, which amino acid sequence is encoded by a polynucleotide, which is contained in the cDNA contained in ATCC™ Deposit No:209603, which was deposited on Jan. 29, 1998.

2. The antibody or fragment thereof of claim 1 that specifically binds (a).

3. The antibody or fragment thereof of claim 1 that specifically binds (b).

4. The antibody or fragment thereof of claim 1 that specifically binds (c).

5. The antibody or fragment thereof of claim 1 that specifically binds (d).

6. The antibody or fragment thereof of claim 1 that specifically binds (e).

7. The antibody or fragment thereof of claim 1 that specifically binds (f).

8. The antibody or fragment thereof of claim 1 that specifically binds (g).

9. The antibody or fragment thereof of claim 1 that specifically binds (h).

10. The antibody or fragment thereof of claim 1 wherein said antibody or fragment thereof is polyclonal.

11. The antibody or fragment thereof of claim 1 wherein said antibody or fragment thereof is monoclonal.

12. The antibody or fragment thereof of claim 1 which is selected from the group consisting of:

(a) a chimeric antibody or fragment thereof;

(b) a humanized antibody or fragment thereof;

(c) a single chain antibody; and

(d) a Fab fragment.

13. A hybridoma that produces the antibody or fragment thereof of claim 1 .

14. A recombinant host cell that expresses the isolated antibody or fragment thereof of claim 1 .

15. A method of making an isolated antibody or fragment thereof comprising:

(a) culturing the recombinant host cell of claim 14 under conditions such that said antibody or fragment thereof is expressed; and

(b) recovering said antibody or fragment thereof.

16. An isolated antibody or fragment thereof that specifically binds a HSDEK49 polypeptide purified from a cell culture wherein said HSDEK49 polypeptide consists of amino acid residues 1 to 399 of SEQ ID NO:1373.

17. The antibody or fragment thereof of claim 16 which is selected from the group consisting of:

(a) a chimeric antibody or fragment thereof;

(b) a humanized antibody or fragment thereof;

(c) a single chain antibody; and

(d) a Fab fragment.

Assignments (1)

Continuity (917)