IP Library › Granted Patent US 9,433,594
Granted Patent B2
US 9,433,594 · App. 14/610,417 · Granted Sep 6, 2016

Technetium- and rhenium-bis(heteroaryl) complexes and methods of use thereof

Inventors: John W. Babich (Tarrytown, NY); Craig Zimmerman (Topsfield, MA); John Joyal (Melrose, MA); Kevin P. Maresca (Tewksbury, MA); John Marquis (Nashua, NH); Genliang Lu (Winchester, MA); Jian-cheng Wang (Revere, MA); Shawn Hillier (Danvers, MA)
Assignee: Molecular Insight Pharmaceuticals, Inc.
A61K31/18
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Quick Facts
Patent No.
US 9,433,594
App. No.
14/610,417
Granted
Sep 6, 2016
Kind
B2
Abstract

A method of imaging a region in a subject includes administering to the subject a complex of a metal chelated to a compound, and obtaining an image of the region in the subject.

Claims (7)

1. A complex represented by any of the following formulae:

wherein n is 0 to 20, and M is a metal.

2. The complex of claim 1 , wherein the metal is a radionuclide.

3. The complex of claim 1 , where in the metal is yttrium, lutetium, gallium, or indium.

4. A pharmaceutical formulation comprising the complex of claim 1 and a pharmaceutically acceptable excipient.

5. A complex which is:

wherein n is 0 to 20, and M is yttrium, lutetium, gallium, or indium.

Assignments (4)
RELEASE OF SECURITY INTEREST Recorded Dec 2, 2022
From: WELLS FARGO BANK, N.A.
To: PROGENICS PHARMACEUTICALS, INC.; MOLECULAR INSIGHT PHARMACEUTICALS, INC.; PSMA DEVELOPMENT COMPANY, LLC
Reel/Frame 062047/0915 →
SECURITY INTEREST Recorded Dec 2, 2022
From: LANTHEUS MEDICAL IMAGING, INC.; MOLECULAR INSIGHT PHARMACEUTICALS, INC.; PSMA DEVELOPMENT COMPANY, LLC; PROGENICS PHARMACEUTICALS, INC.
To: CITIZENS BANK, N.A.
Reel/Frame 062047/0960 →
SECURITY AGREEMENT Recorded Aug 19, 2020
From: PROGENICS PHARMACEUTICALS, INC.; MOLECULAR INSIGHT PHARMACEUTICALS, INC.; PSMA DEVELOPMENT COMPANY LLC
To: WELLS FARGO BANK, N.A.
Reel/Frame 053538/0666 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 11, 2016
From: BABICH, JOHN W.; ZIMMERMAN, CRAIG; JOYAL, JOHN; MARESCA, KEVIN P.; MARQUIS, JOHN; LU, GENLIANG; WANG, JIAN-CHENG; HILLIER, SHAWN
To: MOLECULAR INSIGHT PHARMACEUTICALS, INC.
Reel/Frame 039402/0884 →
Continuity (10)
Continuation 14446220 · Jul 29, 2014
Continuation 14041643 · Sep 30, 2013
Continuation 12631312 · Dec 4, 2009
Continuation In Part 12350894 · Jan 8, 2009
Provisional Application 61120226 · Dec 5, 2008
Provisional Application 61180341 · May 21, 2009
Provisional Application 61020043 · Jan 9, 2008
Provisional Application 61088980 · Aug 14, 2008
Provisional Application 61142002 · Dec 31, 2008
Related Publication 20160222036A1 · Aug 4, 2016