Compounds, compositions and methods useful for cholesterol mobilization
The invention relates to classes of pharmaceutically-active heterocyclic compounds and pharmaceutically acceptable salts, and hydrates thereof, and compositions comprising the same. The invention also relates to methods for treating or preventing a disease or disorder, which comprises administering a therapeutically or prophylactically effective amount a compound described herein.
1. A composition comprising an effective amount of a compound or pharmaceutically acceptable salt of a compound of Formula (XI):
or a pharmaceutically acceptable salt thereof, wherein
R 11a is H, hydrocarbyl, aralkyl, heteroaryl, heterocyclyl, —C(O)(alkyl), —C(O)O(alkyl), —C(O)NH 2 , —C(O)NH(alkyl), —C(O)N(alkyl)(alkyl), or —SO 2 NH 2 ;
each of R 11b and R 11c is independently H, hydrocarbyl, aryl, aralkyl, heteroaryl, heterocyclyl, —C(O)(alkyl), —C(O)O(alkyl), —C(O)NH 2 , —C(O)NH(alkyl), —C(O)N(alkyl)(alkyl), or —SO 2 NH 2 ;
each of X 1 and X 2 is independently CHR 10 , S, O, NR 9 , or N-acyl;
each R 9 is independently H, hydrocarbyl, aryl, aralkyl, heteroaryl, heterocyclyl, —C(O)O(alkyl), —OC(O)(alkyl), —C(O)NH 2 , —C(O)NH(alkyl), —C(O)N(alkyl)(alkyl), —NHC(O)(alkyl), —N(alkyl)C(O)(alkyl), —OC(O)O(alkyl), or —SO 2 NH 2 ;
each R 10 is independently —H, —OH, —NH 2 , —NH(alkyl), —N(alkyl)(alkyl), hydrocarbyl, —O-hydrocarbyl, aryl, —O-aryl, aralkyl, —O-aralkyl, heteroaryl, —O-heteroaryl, heterocyclyl, —O-heterocyclyl, halo, —OCF 3 , —C(O)O(alkyl), —OC(O)(alkyl), —C(O)NH 2 , —C(O)NH(alkyl), —C(O)N(alkyl)(alkyl), —NHC(O)(alkyl), —N(alkyl)C(O)(alkyl), —OC(O)O(alkyl), —OC(O)NH 2 , —OC(O)NH(alkyl), —OC(O)N(alkyl)(alkyl), —CHNH, —CHN(alkyl), or —SO 2 NH 2 ; and
each m is independently an integer from 0-3;
and a pharmaceutically acceptable vehicle or carrier.
2. The composition of claim 1 , wherein the compound has the structure:
or a pharmaceutically acceptable salt thereof.
3. The composition of claim 1 , wherein the composition is formulated for oral administration.
4. The composition of claim 1 , wherein the composition is in the form of a tablet or capsule.
5. The composition of claim 1 , wherein the compound or salt thereof is present in an amount of about 1 mg to about 1,000 mg.
6. A composition comprising an effective amount of a pharmaceutically acceptable carrier or vehicle and a compound of Formula (XI):
or a pharmaceutically acceptable salt thereof, wherein
R 11a is aryl;
each of R 11b and R 11c is independently H, hydrocarbyl, aryl, aralkyl, heteroaryl, heterocyclyl, —C(O)(alkyl), —C(O)O(alkyl), —C(O)NH 2 , —C(O)NH(alkyl), —C(O)N(alkyl)(alkyl), or —SO 2 NH 2 ;
each of X 1 and X 2 is independently CHR 10 , S, O, NR 9 , or N-acyl;
each R 9 is independently H, hydrocarbyl, aryl, aralkyl, heteroaryl, heterocyclyl, —C(O)O(alkyl), —OC(O)(alkyl), —C(O)NH 2 , —C(O)NH(alkyl), —C(O)N(alkyl)(alkyl), —NHC(O)(alkyl), —N(alkyl)C(O)(alkyl), —OC(O)O(alkyl), or —SO 2 NH 2 ;
each R 10 is independently —H, —OH, —NH 2 , —NH(alkyl), —N(alkyl)(alkyl), hydrocarbyl, —O-hydrocarbyl, aryl, —O-aryl, aralkyl, —O-aralkyl, heteroaryl, —O-heteroaryl, heterocyclyl, —O-heterocyclyl, halo, —OCF 3 , —C(O)O(alkyl), —OC(O)(alkyl), —C(O)NH 2 , —C(O)NH(alkyl), —C(O)N(alkyl)(alkyl), —NHC(O)(alkyl), —N(alkyl)C(O)(alkyl), —OC(O)O(alkyl), —OC(O)NH 2 , —OC(O)NH(alkyl), —OC(O)N(alkyl)(alkyl), —CHNH, —CHN(alkyl), or —SO 2 NH 2 ; and
each m is independently an integer from 0-3.
7. The composition of claim 6 , wherein the composition is formulated for oral administration.
8. The composition of claim 6 , wherein the composition is in the form of a tablet or capsule.
9. The composition of claim 6 , wherein the compound or salt thereof is present in an amount of about 1 mg to about 1,000 mg.