Calcium carbonate granulation
Highly compactable granulations and methods for preparing highly compactable granulations are disclosed. More particularly, highly compactable calcium carbonate granulations are disclosed. The granulations comprise powdered materials such as calcium carbonate that have small median particle sizes. The disclosed granulations are useful in pharmaceutical and nutraceutical tableting and provide smaller tablet sizes upon compression than previously available.
1. A calcium carbonate granulation for pharmaceutical or nutraceutical tabletting comprising:
a first powder having a median particle diameter from about 0.1 pin to about 10 μm;
a second powder having a median particle diameter from about 10 μm to about 25 μm;
wherein, said first powder is USP or food grade calcium carbonate;
wherein said second powder is selected from the group consisting of: dicalcium phosphate, calcium sulfate, ferrous sulfate, other iron compounds, lactose, cellulose, micro-crystalline cellulose, kaolin, mannitol, oil, sodium chloride, starch, powdered sugar, talc (magnesium silicate hydroxide), and silica; and
wherein said granulation is highly compactable, has a tap density between about 1.0 and about 2.0 g/cm 3 , is free flowing and has sufficient cohesive properties for compression into tablets.
2. The granulation of claim 1 , wherein said median particle diameter of said first powder is from about 6 μm to about 10 μm.
3. The granulation of claim 1 , wherein said median particle diameter of said first powder is from about 4 μm to about 6 μm.
4. The granulation of claim 1 , wherein said median particle diameter of said first powder is from about 3 μm to about 4 μm.
5. The granulation of claim 1 , wherein said median particle diameter of said first powder is from about 1 μm to about 3 μm.
6. The granulation of claim 1 , wherein said median particle diameter of said first powder is from about 0.1 μm to about 1 μm.
7. The granulation of claim 1 , wherein said granulation comprises at least about 93% said first powder by weight.
8. The granulation of claim 1 , wherein the tap density of the granulation is between about 1.1 and about 2.0 g/cm 3 .
9. A calcium carbonate granulation for pharmaceutical or nutraceutical tabletting comprising:
a first powder having a median particle diameter from about 0.1 μm to about 10 μm;
a second powder having a median particle diameter from about 10 μm to about 25 μm;
wherein said first powder is selected from the group consisting of: dicalcium phosphate, calcium sulfate, ferrous sulfate, other iron compounds, lactose, cellulose, micro-crystalline cellulose, kaolin, mannitol, oil, sodium chloride, starch, powdered sugar, talc (magnesium silicate hydroxide), and silica;
wherein, said second powder is USP or food grade calcium carbonate; and
wherein said granulation is highly compactable, has a tap density between about 1.0 and about 2.0 g/cm 3 , is free flowing and has sufficient cohesive properties for compression into tablets.
10. The granulation of claim 1 , wherein the median particle diameter of said second powder is from about 10 μm to about 12 μm.
11. The granulation of claim 1 , wherein the median particle diameter of said second powder is from about 12 μm to about 15 μm.
12. The granulation of claim 1 , wherein the median particle diameter of said second powder is from about 15 μm to about 20 μm.
13. The granulation of claim 1 , wherein the median particle diameter of said second powder is from about 20 μm to about 25 μm.
14. The granulation of claim 1 , wherein said granulation comprises at least about 93% said second powder by weight.
15. The granulation of claim 1 , wherein the tap density of the granulation is between about 1.1 and about 2.0 g/cm 3 .