IP Library Granted Patent US 10,555,921
Granted Patent B1
US 10,555,921 · App. 14/617,571 · Granted Feb 11, 2020

Amino acid compositions

Inventors: Ronald Kramer (Phoenix, AZ); Alexander Nikolaidis (New Kallikratia, GR)
Assignee: ThermoLife International, LLC
A61K31/198
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Quick Facts
Patent No.
US 10,555,921
App. No.
14/617,571
Granted
Feb 11, 2020
Kind
B1
Abstract

A composition and a supplement formulation includes: at least one constituent selected from the group consisting of a nitrate salt; and at least one constituent amino acid selected from the group consisting of Arginine, Agmatine, Beta Alanine, Citrulline, Creatine, Glutamine, L-Histidine, Isoleucine, Leucine, Norvaline, Ornithine, Valine, Aspartic Acid, Cysteine, Glycine, Lysine, Methionine, Proline, Tyrosine, and Phenylalanine.

Claims (145)

1. An oral composition for human ingestion comprising:

at least one isolated nitrate salt selected from the group consisting of a salt of an amino acid and an inorganic nitrate salt; and

at least one constituent amino acid selected from the group consisting arginine, agmatine, beta alanine, citrulline, creatine, glutamine, L-histidine, isoleucine, leucine, norvaline, ornithine, valine, aspartic acid, cysteine, glycine, lysine, methionine, proline, tyrosine, and phenylalanine,

wherein the isolated nitrate salt is a separate constituent from the at least one constituent amino acid and the oral composition is in a dosage form selected from the group consisting of a capsule, a cachet, a pill, a tablet, a pellet, a bead, a troche, a lozenge, and a gel.

2. The oral composition of claim 1 , wherein the at least one constituent amino acid is arginine.

3. The oral composition of claim 1 , wherein the at least one constituent amino acid is agmatine.

4. The oral composition of claim 1 , wherein the at least one constituent amino acid is beta alanine.

5. The oral composition of claim 1 , wherein the at least one constituent amino acid is citrulline.

6. The oral composition of claim 1 , wherein the at least one constituent amino acid is creatine.

7. The oral composition of claim 1 , wherein the at least one constituent amino acid is glutamine.

8. The oral composition of claim 1 , wherein the at least one constituent amino acid is L-histidine.

9. The oral composition of claim 1 , wherein the at least one constituent amino acid is isoleucine.

10. The oral composition of claim 1 , wherein the at least one constituent amino acid is leucine.

11. The oral composition of claim 1 , wherein the at least one constituent amino acid is norvaline.

12. The oral composition of claim 1 , wherein the at least one constituent amino acid is ornithine.

13. The oral composition of claim 1 , wherein the at least one constituent amino acid is valine.

14. The oral composition of claim 1 , wherein the at least one constituent amino acid is aspartic acid.

15. The oral composition of claim 1 , wherein the at least one constituent amino acid is cysteine.

16. The oral composition of claim 1 , wherein the at least one constituent amino acid is glycine.

17. The oral composition of claim 1 , wherein the at least one constituent amino acid is lysine.

18. The oral composition of claim 1 , wherein the at least one constituent amino acid is methionine.

19. The oral composition of claim 1 , wherein the at least one constituent amino acid is proline.

20. The oral composition of claim 1 , wherein the at least one constituent amino acid is tyrosine.

21. The oral composition of claim 1 , wherein the at least one constituent amino acid is phenylalanine.

22. The oral composition of claim 1 further comprising one or more additional components selected from the group consisting of a carrier, an excipient, a binder, a colorant, a flavoring agent, a preservative, a buffer, a dilutant, and any combination thereof.

23. The oral composition of claim 1 , wherein the isolated nitrate salt comprises an inorganic nitrate salt selected from the group consisting of: sodium nitrate, potassium nitrate, calcium nitrate, and any combination thereof.

24. The oral composition of claim 23 , wherein the isolated nitrate salt comprises sodium nitrate.

25. The oral composition of claim 23 , wherein the isolated nitrate salt comprises potassium nitrate.

26. A supplement formulation for human ingestion comprising:

at least one constituent selected from the group consisting of an isolated nitrate salt selected from the group consisting of a salt of an amino acid and an inorganic nitrate salt; and

at least one constituent amino acid selected from the group consisting of arginine, agmatine, beta alanine, citrulline, creatine, glutamine, L-histidine, isoleucine, leucine, norvaline, ornithine, valine, aspartic acid, cysteine, glycine, lysine, methionine, proline, tyrosine, and phenylalanine,

wherein the isolated nitrate salt is a separate constituent from the at least one constituent amino acid and the supplement formulation is in a dosage form selected from the group consisting of a capsule, a cachet, a pill, a tablet, a pellet, a bead, a troche, a lozenge, and a gel.

27. The supplement formulation of claim 23 , wherein the at least one constituent amino acid is arginine.

28. The supplement formulation of claim 23 , wherein the at least one constituent amino acid is agmatine.

29. The supplement formulation of claim 23 , wherein the at least one constituent amino acid is beta alanine.

30. The supplement formulation of claim 23 , wherein the at least one constituent amino acid is citrulline.

31. The supplement formulation of claim 23 , wherein the at least one constituent amino acid is creatine.

32. The supplement formulation of claim 23 , wherein the at least one constituent amino acid is glutamine.

33. The supplement formulation of claim 23 , wherein the at least one constituent amino acid is L-histidine.

34. The supplement formulation of claim 23 , wherein the at least one constituent amino acid is isoleucine.

35. The supplement formulation of claim 23 , wherein the at least one constituent amino acid is leucine.

36. The supplement formulation of claim 23 , wherein the at least one constituent amino acid is norvaline.

37. The supplement formulation of claim 23 , wherein the at least one constituent amino acid is ornithine.

38. The supplement formulation of claim 23 , wherein the at least one constituent amino acid is valine.

39. The supplement formulation of claim 23 , wherein the at least one constituent amino acid is aspartic acid.

40. The supplement formulation of claim 23 , wherein the at least one constituent amino acid is cysteine.

41. The supplement formulation of claim 23 , wherein the at least one constituent amino acid is glycine.

42. The supplement formulation of claim 23 , wherein the at least one constituent amino acid is lysine.

43. The supplement formulation of claim 23 , wherein the at least one constituent amino acid is methionine.

44. The supplement formulation of claim 23 , wherein the at least one constituent amino acid is proline.

45. The supplement formulation of claim 23 , wherein the at least one constituent amino acid is tyrosine.

46. The supplement formulation of claim 23 , wherein the at least one constituent amino acid is phenylalanine.

47. The supplement formulation of claim 26 further comprising one or more additional components selected from the group consisting of a carrier, an excipient, a binder, a colorant, a flavoring agent, a preservative, a buffer, a dilutant, and any combination thereof.

48. The supplement formulation claim 26 , wherein the isolated nitrate salt comprises an inorganic nitrate salt selected from the group consisting of: sodium nitrate, potassium nitrate, calcium nitrate, and any combination thereof.

49. The supplement formulation of claim 48 , wherein the isolated nitrate salt comprises sodium nitrate.

50. The supplement formulation of claim 48 , wherein the isolated nitrate salt comprises potassium nitrate.

51. The oral composition of claim 1 , wherein the oral composition is a human dietary supplement.

52. An oral composition for human ingestion comprising:

at least one constituent selected from the group consisting of an isolated nitrate salt selected from the group consisting of a salt of an amino acid and an inorganic nitrate salt;

at least one constituent amino acid selected from the group consisting arginine, agmatine, beta alanine, citrulline, creatine, glutamine, L-histidine, isoleucine, leucine, norvaline, ornithine, valine, aspartic acid, cysteine, glycine, lysine, methionine, proline, tyrosine, and phenylalanine; and

one or more additional components selected from the group consisting of: a binder, a colorant, a lubricant, and a flavoring agent;

wherein the isolated nitrate salt is a separate constituent from the at least one constituent amino acid and the oral composition is in a dosage form selected from the group consisting of a powder, a granule, and a particle.

53. A supplement formulation for human ingestion comprising:

at least one constituent selected from the group consisting of an isolated nitrate salt selected from the group consisting of a salt of an amino acid and an inorganic nitrate salt;

at least one constituent amino acid selected from the group consisting arginine, agmatine, beta alanine, citrulline, creatine, glutamine, L-histidine, isoleucine, leucine, norvaline, ornithine, valine, aspartic acid, cysteine, glycine, lysine, methionine, proline, tyrosine, and phenylalanine; and

one or more additional components selected from the group consisting of: a binder, a colorant, a lubricant, and a flavoring agent;

wherein the isolated nitrate salt is a separate constituent from the at least one constituent amino acid and the supplement formulation is in a dosage form selected from the group consisting of a powder, a granule, and a particle.

54. The oral composition of claim 52 , wherein the at least one constituent amino acid is arginine.

55. The oral composition of claim 52 , wherein the at least one constituent amino acid is agmatine.

56. The oral composition of claim 52 , wherein the at least one constituent amino acid is beta alanine.

57. The oral composition of claim 52 , wherein the at least one constituent amino acid is citrulline.

58. The oral composition of claim 52 , wherein the at least one constituent amino acid is creatine.

59. The oral composition of claim 52 , wherein the at least one constituent amino acid is glutamine.

60. The oral composition of claim 52 , wherein the at least one constituent amino acid is L-histidine.

61. The oral composition of claim 52 , wherein the at least one constituent amino acid is isoleucine.

62. The oral composition of claim 52 , wherein the at least one constituent amino acid is leucine.

63. The oral composition of claim 52 , wherein the at least one constituent amino acid is norvaline.

64. The oral composition of claim 52 , wherein the at least one constituent amino acid is ornithine.

65. The oral composition of claim 52 , wherein the at least one constituent amino acid is valine.

66. The oral composition of claim 52 , wherein the at least one constituent amino acid is aspartic acid.

67. The oral composition of claim 52 , wherein the at least one constituent amino acid is cysteine.

68. The oral composition of claim 52 , wherein the at least one constituent amino acid is glycine.

69. The oral composition of claim 52 , wherein the at least one constituent amino acid is lysine.

70. The oral composition of claim 52 , wherein the at least one constituent amino acid is methionine.

71. The oral composition of claim 52 , wherein the at least one constituent amino acid is proline.

72. The oral composition of claim 52 , wherein the at least one constituent amino acid is tyrosine.

73. The oral composition of claim 52 , wherein the at least one constituent amino acid is phenylalanine.

74. The supplement formulation of claim 53 , wherein the at least one constituent amino acid is arginine.

75. The supplement formulation of claim 53 , wherein the at least one constituent amino acid is agmatine.

76. The supplement formulation of claim 53 , wherein the at least one constituent amino acid is beta alanine.

77. The supplement formulation of claim 53 , wherein the at least one constituent amino acid is citrulline.

78. The supplement formulation of claim 53 , wherein the at least one constituent amino acid is creatine.

79. The supplement formulation of claim 53 , wherein the at least one constituent amino acid is glutamine.

80. The supplement formulation of claim 53 , wherein the at least one constituent amino acid is L-histidine.

81. The supplement formulation of claim 53 , wherein the at least one constituent amino acid is isoleucine.

82. The supplement formulation of claim 53 , wherein the at least one constituent amino acid is leucine.

83. The supplement formulation of claim 53 , wherein the at least one constituent amino acid is norvaline.

84. The supplement formulation of claim 53 , wherein the at least one constituent amino acid is ornithine.

85. The supplement formulation of claim 53 , wherein the at least one constituent amino acid is valine.

86. The supplement formulation of claim 53 , wherein the at least one constituent amino acid is aspartic acid.

87. The supplement formulation of claim 53 , wherein the at least one constituent amino acid is cysteine.

88. The supplement formulation of claim 53 , wherein the at least one constituent amino acid is glycine.

89. The supplement formulation of claim 53 , wherein the at least one constituent amino acid is lysine.

90. The supplement formulation of claim 53 , wherein the at least one constituent amino acid is methionine.

91. The supplement formulation of claim 53 , wherein the at least one constituent amino acid is proline.

92. The supplement formulation of claim 53 , wherein the at least one constituent amino acid is tyrosine.

93. The supplement formulation of claim 53 , wherein the at least one constituent amino acid is phenylalanine.

94. The oral composition of claim 52 , wherein the isolated nitrate salt is a salt of an amino acid.

95. The oral composition of claim 52 , wherein the isolated nitrate salt is an inorganic nitrate salt.

96. The oral composition of claim 52 , wherein the isolated nitrate salt is sodium nitrate.

97. The oral composition of claim 52 , wherein the isolated nitrate salt is potassium nitrate.

98. The supplement formulation of claim 53 , wherein the isolated nitrate salt is a salt of an amino acid.

99. The supplement formulation of claim 53 , wherein the isolated nitrate salt is an inorganic nitrate salt.

100. The supplement formulation of claim 53 , wherein the isolated nitrate salt is sodium nitrate.

101. The supplement formulation of claim 53 , wherein the isolated nitrate salt is potassium nitrate.

102. The oral composition of claim 1 , wherein the dosage form is a capsule.

103. The oral composition of claim 1 , wherein the dosage form is a cachet.

104. The oral composition of claim 1 , wherein the dosage form is a pill.

105. The oral composition of claim 1 , wherein the dosage form is a tablet.

106. The oral composition of claim 1 , wherein the dosage form is a pellet.

107. The oral composition of claim 1 , wherein the dosage form is a bead.

108. The oral composition of claim 1 , wherein the dosage form is a troche.

109. The oral composition of claim 1 , wherein the dosage form is a lozenge.

110. The oral composition of claim 1 , wherein the dosage form is a gel.

111. The oral composition of claim 52 , wherein the dosage form is a powder.

112. The oral composition of claim 52 , wherein the dosage form is a granule.

113. The oral composition of claim 52 , wherein the dosage form is a particle.

114. The supplement formulation of claim 13 , wherein the dosage form is a capsule.

115. The supplement formulation of claim 13 , wherein the dosage form is a cachet.

116. The supplement formulation of claim 13 , wherein the dosage form is a pill.

117. The supplement formulation of claim 13 , wherein the dosage form is a tablet.

118. The supplement formulation of claim 13 , wherein the dosage form is a pellet.

119. The supplement formulation of claim 13 , wherein the dosage form is a bead.

120. The supplement formulation of claim 13 , wherein the dosage form is a troche.

121. The supplement formulation of claim 13 , wherein the dosage form is a lozenge.

122. The supplement formulation of claim 13 , wherein the dosage form is a gel.

123. The supplement formulation of claim 53 , wherein the dosage form is a powder.

124. The supplement formulation of claim 53 , wherein the dosage form is a granule.

125. The supplement formulation of claim 53 , wherein the dosage form is a particle.

126. The oral composition of claim 22 , wherein the at least one constituent amino acid is creatine and the one or more additional components is an excipient.

127. The oral composition of claim 22 , wherein the at least one constituent amino acid is creatine and the one or more additional components is a flavoring agent.

128. The oral composition of claim 22 , wherein the at least one constituent amino acid is creatine and the one or more additional components is a colorant.

129. The supplement formulation of claim 47 , wherein the at least one constituent amino acid is creatine and the one or more additional components is an excipient.

130. The supplement formulation of claim 47 , wherein the at least one constituent amino acid is creatine and the one or more additional components is a flavoring agent.

131. The supplement formulation of claim 47 , wherein the at least one constituent amino acid is creatine and the one or more additional components is a colorant.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 18, 2015
From: KRAMER, RONALD; NIKOLAIDIS, ALEXANDER
To: THERMOLIFE INTERNATIONAL, LLC
Reel/Frame 035021/0811 →
Continuity (5)
Continuation 13920081 · Jun 17, 2013
Continuation 13038615 · Mar 2, 2011
Continuation In Part 12336938 · Dec 17, 2008
Continuation 11950273 · Dec 4, 2007
Provisional Application 60973229 · Sep 18, 2007
Cited By (9)
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