Granted Patent
B1
US 12,448,357 · App. 18/745,858 · Granted Oct 21, 2025
Amino acid compositions
Assignee:
ThermoLife International, LLC
C07D233/64A61K31/185A61K31/197A61K31/198A61K31/205A61K31/221A61K31/401A61K31/4172A61K33/00C07C229/08C07C229/24C07C229/26C07C237/06C07C275/16C07C279/02C07C323/58C07D207/16
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Abstract
Methods of improving pharmacodynamic properties of an amino acid in a human subject is disclosed. The method comprises administering to the human subject the amino acid in the form of a nitrate salt, wherein the nitrate salt form of the amino acid is faster acting compared to other forms of the amino acid.
Claims (24)
1. A method of providing an amino acid with faster onset of action to a human subject, the method comprising orally administering the amino acid in the form of a nitrate salt, wherein the nitrate salt form of the amino acid is faster acting compared to other forms of the amino acid.
2. The method of claim 1 , wherein the nitrate salt is arginine nitrate.
3. The method of claim 2 , wherein arginine nitrate is faster acting compared to other forms of arginine in at least one effect selected from the group consisting of: boosting human growth hormone (HGH) production, increasing vasodilation, enhancing blood circulation, increasing oxygen flow to muscles, boosting nitric oxide (NO) production, and increasing athletic performance.
4. The method of claim 1 , wherein the nitrate salt is citrulline nitrate.
5. The method of claim 4 , wherein citrulline nitrate is faster acting compared to other forms of citrulline in increasing athletic performance.
6. The method of claim 1 , wherein the nitrate salt is creatine nitrate.
7. The method of claim 6 , wherein creatine nitrate is faster acting compared to other forms of creatine in at least one effect selected from the group consisting of: increasing muscular energy, increasing muscle-mass gains, improving athletic performance, improving strength, and increasing athletic performance.
8. The method of claim 1 , wherein the nitrate salt is glutamine nitrate.
9. The method of claim 8 , wherein glutamine nitrate is faster acting compared to other forms of glutamine in increasing athletic performance.
10. The method of claim 1 , wherein the nitrate salt is leucine nitrate.
11. The method of claim 10 , wherein the leucine nitrate is faster acting compared to other forms of leucine in at least one effect selected from the group consisting of: increasing muscle protein synthesis, inhibiting protein degradation in skeletal muscle, inhibiting protein degradation in the liver, stimulating muscle protein synthesis, and increasing athletic performance.
12. The method of claim 1 , wherein the nitrate salt is valine nitrate.
13. The method of claim 12 , wherein the valine nitrate is faster acting compared to other forms of valine in at least one effect selected from the group consisting of: increasing muscle protein synthesis, inhibiting protein degradation in skeletal muscle, inhibiting protein degradation in the liver, stimulating muscle protein synthesis, and increasing athletic performance.
14. The method of claim 1 , wherein the nitrate salt is isoleucine nitrate.
15. The method of claim 14 , wherein the isoleucine nitrate is faster acting compared to other forms of isoleucine in at least one effect selected from the group consisting of: increasing muscle protein synthesis, inhibiting protein degradation in skeletal muscle, inhibiting protein degradation in the liver, stimulating muscle protein synthesis, and increasing athletic performance.
16. The method of claim 1 , wherein the nitrate salt is norvaline nitrate.
17. The method of claim 16 wherein the norvaline nitrate is faster acting compared to other forms of norvaline in at least one effect selected from the group consisting of: inhibiting arginase enzyme and increasing athletic performance.
18. The method of claim 1 , wherein the nitrate salt is ornithine nitrate.
19. The method of claim 18 , wherein the ornithine nitrate is faster acting compared to other forms of ornithine in at least one effect selected from the group consisting of: increasing arginine production and enhancing vasodilation.
20. The method of claim 1 , wherein the nitrate salt is histidine nitrate.
21. The method of claim 20 , wherein the histidine nitrate is faster acting compared to other forms of histidine in at least one effect selected from the group consisting of: increasing carnosine production and increasing athletic performance.
22. The method of claim 1 , wherein the nitrate salt is beta alanine nitrate.
23. The method of claim 22 , wherein the beta alanine nitrate is faster acting compared to other forms of beta alanine in at least one effect selected from the group consisting of: increasing carnosine production and increasing of athletic performance.
24. The method of claim 1 , wherein the nitrate salt is agmatine nitrate, and wherein the agmatine nitrate is faster acting compared to other forms of agmatine in stimulating nitric oxide synthase (NOS).
Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Aug 8, 2024
From: KRAMER, RONALD; NIKOLAIDIS, ALEXANDROS
To: THERMOLIFE INTERNATIONAL, LLC
Reel/Frame 068229/0412 →
Continuity (7)
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