Method of safely administering nitrate dietary supplements and compositions
A method of making a composition or a dietary supplement is provided, the method comprising combining a quantity of a Nitrate with a quantity of an Amino Acid Compound, wherein the combining of the Nitrate with the Amino Acid Compound reduces a side effect or toxicity of the Nitrate. Also provided is a method of safely administering to a subject a Nitrate with a reduced side effect or toxicity, the method comprising: combining a quantity of the Nitrate with a quantity of an Amino Acid Compound in a composition or a dietary supplement, wherein the combining of the Nitrate with the Amino Acid Compound reduces the side effect or toxicity of the Nitrate; and safely administering to the subject the composition or dietary supplement comprising the Nitrate with the reduced side effect or toxicity.
1. A method of safely administering to a subject a nitrate with a reduced side effect, the method comprising:
combining a quantity of an inorganic nitrate with a quantity of an amino acid compound to produce a composition or a dietary supplement comprising an amino acid nitrate salt, wherein the combining of the inorganic nitrate salt with the amino acid compound reduces the side effect or toxicity of the inorganic nitrate; and
orally administering to the subject the composition or dietary supplement, wherein the subject has reduced side effect or toxicity from the inorganic nitrate and the quantity of the amino acid compound is at least the quantity of the inorganic nitrate,
wherein the side effect is selected from the group consisting of nausea, gastric distress, gastric ulcer, diarrhea, abdominal pain, and methemoglobinemia, and the amino acid compound is selected from the group consisting of agmatine, arginine, asparagine, aspartic acid, beta alanine, betaine, carnitine, citrulline, creatine, cysteine, glutamine, glutamic acid, glycine, histidine, isoleucine, leucine, lysine, methionine, norvaline, phenylalanine, ornithine, proline, taurine, tyrosine, and valine.
2. The method of claim 1 , wherein the amino acid compound is selected from the group consisting of arginine, beta alanine, citrulline, histidine, isoleucine, leucine, lysine, methionine, phenylalanine, and valine.
3. The method of claim 1 , wherein the quantity of the amino acid compound is about the same as the quantity of the inorganic nitrate.
4. The method of claim 1 , wherein the quantity of the amino acid compound is greater than the quantity of the inorganic nitrate.
5. The method of claim 4 , wherein the amino acid compound is selected from the group consisting of isoleucine, leucine, methionine, norvaline, phenylalanine, ornithine, proline, taurine, tyrosine, and valine.
6. The method of claim 1 , wherein the amino acid compound is selected from the group consisting of arginine, histidine, and lysine, the percentage of the amino acid compound in the composition is at least 15% (mole percent).
7. The method of claim 6 , wherein the amino acid compound is selected from the group consisting of arginine, histidine, and lysine, the percentage of the amino acid compound in the composition is at least 25% (mole percent).
8. The method of claim 7 , wherein the molar ratio of the quantity of the amino acid compound and the quantity of the inorganic nitrate is about 1:2.
9. The method of claim 1 , wherein the amino acid compound is selected from the group consisting of agmatine, asparagine, aspartic acid, beta alanine, betaine, carnitine, citrulline, creatine, cysteine, glutamine, glutamic acid, glycine, isoleucine, leucine, methionine, norvaline, phenylalanine, ornithine, proline, taurine, tyrosine, and valine, the percentage of the amino acid compound in the composition is at least 30% (mole percent).
10. The method of claim 1 , wherein the amino acid compound is selected from the group consisting of agmatine, asparagine, aspartic acid, beta alanine, betaine, carnitine, citrulline, creatine, cysteine, glutamine, glutamic acid, glycine, isoleucine, leucine, methionine, norvaline, phenylalanine, ornithine, proline, taurine, tyrosine, and valine, the percentage of the amino acid compound in the composition is at least 50% (mole percent).
11. The method of claim 1 , wherein the composition or dietary supplement is in a dosage form selected from the group consisting of a capsule, a cachet, a pill, a tablet, a powder, a granule, a pellet, a bead, a particle, a troche, a lozenge, a gel, a liquid, a suspension, a solution, an elixir, and a syrup.
12. The method of claim 1 , further comprising combining a quantity of ascorbic acid to the composition or dietary supplement comprising a quantity of the inorganic nitrate and a quantity of the amino acid compound.
13. The method of claim 12 , where in the quantity of ascorbic acid is 30-500 mg.
14. The method of claim 1 , wherein the composition or dietary supplement provides an effective dose of about 50 mg of the inorganic nitrate to about 10,000 mg of the inorganic nitrate.
15. The method of claim 14 , wherein the composition or dietary supplement does not cause nausea, gastric distress, gastric ulcer, diarrhea, abdominal pain, and methemoglobinemia at the effective dose.
16. The method of claim 1 , wherein the amino acid nitrate salt is administered to the subject in an effective amount to ameliorate tolerance to dilator effects of nitrates, to increase bioabsorption of amino acids, to increase the vasodilative characteristics of amino acids, or to increase athletic performance and conditioning.
17. The method of claim 1 , wherein the amino acid compound is agmatine.
18. The method of claim 1 , wherein the amino acid compound is arginine.
19. The method of claim 1 , wherein the amino acid compound is asparagine.
20. The method of claim 1 , wherein the amino acid compound is aspartic acid.
21. The method of claim 1 , wherein the amino acid compound is beta alanine.
22. The method of claim 1 , wherein the amino acid compound is betaine.
23. The method of claim 1 , wherein the amino acid compound is carnitine.
24. The method of claim 1 , wherein the amino acid compound is citrulline.
25. The method of claim 1 , wherein the amino acid compound is creatine.
26. The method of claim 1 , wherein the amino acid compound is cysteine.
27. The method of claim 1 , wherein the amino acid compound is glutamine.
28. The method of claim 1 , wherein the amino acid compound is glutamic acid.
29. The method of claim 1 , wherein the amino acid compound is glycine.
30. The method of claim 1 , wherein the amino acid compound is histidine.
31. The method of claim 1 , wherein the amino acid compound is isoleucine.
32. The method of claim 1 , wherein the amino acid compound is leucine.
33. The method of claim 1 , wherein the amino acid compound is lysine.
34. The method of claim 1 , wherein the amino acid compound is methionine.
35. The method of claim 1 , wherein the amino acid compound is norvaline.
36. The method of claim 1 , wherein the amino acid compound is phenylalanine.
37. The method of claim 1 , wherein the amino acid compound is ornithine.
38. The method of claim 1 , wherein the amino acid compound is proline.
39. The method of claim 1 , wherein the amino acid compound is taurine.
40. The method of claim 1 , wherein the amino acid compound is tyrosine.
41. The method of claim 1 , wherein the amino acid compound is valine.