IP Library Granted Patent US 10,542,994
Granted Patent B2
US 10,542,994 · App. 15/152,935 · Granted Jan 28, 2020

Methods for treating abnormal growths in the body using a flow reducing implant

Inventors: Shmuel Ben-Muvhar (D.N. Modiin, IL); Ilan Shalev (Givatayim, IL); Jonathan Tsehori (Ramat Gan, IL); Nissim Darvish (Tzerufa, IL)
Assignee: Neovasc Medical Ltd.
A61B17/12036A61B17/12109A61B17/12172A61F2/848A61F2/90A61F2/91A61F2/915A61F2/958A61F2002/068A61F2002/9155A61F2002/91525A61F2002/91533A61F2002/91575A61F2210/0076A61F2220/0016A61F2220/0075A61F2230/008A61F2230/0078A61F2250/0018
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Quick Facts
Patent No.
US 10,542,994
App. No.
15/152,935
Granted
Jan 28, 2020
Kind
B2
Abstract

A flow reducing implant for reducing blood flow in a blood vessel having a cross sectional dimension, the flow reducing implant comprising a hollow element adapted for placement in the blood vessel defining a flow passage therethrough, said flow passage comprising at least two sections, one with a larger diameter and one with a smaller diameter, wherein said smaller diameter is smaller than a cross section of the blood vessel. A plurality of tabs anchor, generally parallel to the blood vessel wall, are provided in some embodiments of the invention.

Claims (36)

1. A method of treating a blood flow problem in a limb of patient, said method comprising:

identifying a presence of the blood flow problem in the limb;

inserting a flow reducing implant into a vein in the limb;

radially expanding the flow reducing implant within the vein;

engaging a first flared end and a second flared end of the flow reducing implant with the vein, wherein the flow reducing implant comprises a narrowed section positioned between the first flared end and the second flared end and defining a flow passage therethrough,

wherein the flow reducing implant comprises one or more slits located on one or more of the narrowed section, the first flared end, and the second flared end, and

wherein the one or more slits of the first and the second flared ends are on average larger than the one or more slits of the narrowed section;

reducing flow in the vein with the flow reducing implant; and

redistributing blood in the limb.

2. The method of claim 1 , wherein the one or more slits are located on each of the narrowed section, the first flared end, and the second flared end and the one or more slits that are located on each of the narrowed section, the first flared end, and the second flared end have a configuration that provides a greater stiffness to the narrowed section than the first flared end and the second flared end.

3. The method of claim 2 , wherein the one or more slits have a configuration that allows the first and the second flared ends to expand to a diameter larger than the narrowed section.

4. The method of claim 1 , wherein a diameter of the flow passage is substantially fixed by a configuration of the one or more slits on the narrowed section.

5. The method of claim 1 , wherein a configuration of the one or more slits on the first and the second flared ends allow the first and the second flared ends to expand within the blood vessel to a size that firmly secures the flow reducing implant within the blood vessel.

6. The method of claim 1 , wherein the flow reducing implant is coated with a biologically inert material.

7. The method of claim 1 , wherein the flow reducing implant is coated with materials that promote tissue ingrowth.

8. The method of claim 1 , wherein the narrowed section is configured to decrease blood flow through the blood vessel.

9. The method of claim 1 , wherein the first flared end has a first diameter and the second flared end has a second diameter, and wherein the first diameter is larger than the second diameter.

10. The method of claim 9 , wherein the first and the second diameters are governed by the configuration of the one or more slits on the first and the second flared ends.

11. A method of treating a blood flow problem in a limb of patient, said method comprising:

identifying a presence of the blood flow problem in the limb;

inserting a flow reducing implant into a vein in the limb;

radially expanding the flow reducing implant within the vein;

engaging a first flared end and a second flared end of the flow reducing implant with the vein, wherein the flow reducing implant comprises a narrowed section positioned between the first flared end and the second flared end and defining a flow passage therethrough,

wherein the flow reducing implant comprises one or more slits located on one or more of the narrowed section, the first flared end, and the second flared end, and

wherein the first flared end has a first diameter and the second flared end has a second diameter, and wherein the first diameter is larger than the second diameter;

reducing flow in the vein with the flow reducing implant; and

redistributing blood in the limb.

12. The method of claim 11 , wherein the one or more slits are located on each of the narrowed section, the first flared end, and the second flared end and the one or more slits that are located on each of the narrowed section, the first flared end, and the second flared end have a configuration that provides a greater stiffness to the narrowed section than the first flared end and the second flared end.

13. The method of claim 12 , wherein the one or more slits have a configuration that allows the first and the second flared ends to expand to a diameter larger than the narrowed section.

14. The method of claim 11 , wherein a diameter of the flow passage is substantially fixed by a configuration of the one or more slits on the narrowed section.

15. The method of claim 11 , wherein a configuration of the one or more slits on the first and the second flared ends allow the first and the second flared ends to expand within the blood vessel to a size that firmly secures the flow reducing implant within the blood vessel.

16. The method of claim 11 , wherein the one or more slits of the first and the second flared ends are on average larger than the one or more slits of the narrowed section.

17. The method of claim 11 , wherein the flow reducing implant is coated with a biologically inert material.

18. The method of claim 11 , wherein the flow reducing implant is coated with materials that promote tissue ingrowth.

19. The method of claim 11 , wherein the narrowed section is configured to decrease blood flow through the blood vessel.

20. The method of claim 11 , wherein the first and the second diameters are governed by the configuration of the one or more slits on the first and the second flared ends.

Assignments (6)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 28, 2024
From: NEOVASC MEDICAL LTD.
To: SHOCKWAVE MEDICAL, INC.
Reel/Frame 066942/0164 →
RELEASE OF SECURITY INTEREST Recorded Jun 9, 2020
From: BIO IP VENTURES II LLC, AS COLLATERAL AGENT
To: NEOVASC MEDICAL LTD.
Reel/Frame 052874/0308 →
DEBENTURE Recorded Apr 27, 2018
From: NEOVASC MEDICAL LTD.
To: BIO IP VENTURES II LLC, AS COLLATERAL AGENT
Reel/Frame 046339/0332 →
RELEASE OF SECURITY INTEREST IN INTELLECTUAL PROPERTY COLLATERAL AT REEL/FRAME NO. 41269/0244 Recorded Jan 12, 2018
From: EDWARDS LIFESCIENCES CARDIAQ LLC
To: NEOVASC INC.; NEOVASC TIARA INC.
Reel/Frame 045060/0001 →
SECURITY INTEREST Recorded Jan 5, 2017
From: NEOVASC INC.; NEOVASC TIARA INC.
To: EDWARDS LIFESCIENCES CARDIAQ LLC
Reel/Frame 041269/0244 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 11, 2016
From: BEN MUVHAR, SHMUEL; SHALEV, ILAN; TSEHORI, JONATHAN; DARVISH, NISSIM
To: NEOVASC MEDICAL LTD.
Reel/Frame 039988/0424 →
Priority Claims (2)
IL 145750 · Oct 4, 2001 · national
IL 151162 · Aug 8, 2002 · national
Continuity (7)
Continuation 14506403 · Oct 3, 2014
Continuation 14026816 · Sep 13, 2013
Continuation 12603518 · Oct 21, 2009
Continuation 10491976
Continuation In Part PCTIL0100284 · Mar 27, 2001
Continuation 09534968 · Mar 27, 2000
Related Publication 20160256169A1 · Sep 8, 2016
Cited By (12)
US 12,251,529 US 12,296,122 US 12,303,390 US 12,311,134 US 12,349,912 US 12,369,918 US 12,453,626 US 12,465,485 US 12,465,488 US 12,502,272 US 12,599,756 US 12,691,267