Intraosseous nerve treatment
Methods and systems for modulating intraosseous nerves (e.g., nerves within bone) are provided. For example, the methods and systems described herein may be used to modulate (e.g., denervate, ablate) basivertebral nerves within vertebrae. The modulation of the basivertebral nerves may facilitate treatment of chronic back pain. The modulation may be performed by a neuromodulation device (e.g., an energy delivery device).
1. A method of treating back pain from a location within a bone of a spine, comprising:
inserting a distal end portion of a radiofrequency energy delivery device having two electrodes through an outer cortical bone region of the bone and within an inner cancellous bone region of the bone,
positioning a first electrode of the two electrodes on a first side of a nerve within the bone and positioning a second electrode of the two electrodes on a second side of the nerve within the bone; and
applying radiofrequency energy to the inner cancellous bone region of the bone, thereby generating heat sufficient to ablate at least a portion of the nerve within the inner cancellous bone region of the bone.
2. The method of claim 1 , wherein the nerve comprises a basivertebral nerve and wherein positioning the first electrode and positioning the second electrode comprises positioning the electrodes at a location such that a single treatment denervates each branch downstream of a junction of the basivertebral nerve.
3. The method of claim 1 wherein positioning the first electrode and positioning the second electrode comprises positioning the electrodes to straddle the nerve.
4. The method of claim 1 , wherein the nerve comprises a basivertebral nerve and wherein positioning the first electrode and positioning the second electrode comprises positioning the two electrodes at positions within the inner cancellous bone region between a junction of the basivertebral nerve and the outer cortical bone region.
5. The method of claim 1 , wherein the radiofrequency energy delivery device is a bipolar radiofrequency energy delivery probe, and wherein the two electrodes comprise an active electrode at a distal tip of the bipolar radiofrequency energy delivery probe and a return electrode spaced proximal to the active electrode.
6. The method of claim 1 , wherein inserting the distal end portion of the radiofrequency energy delivery device having two electrodes through the outer cortical bone region of the bone and within the inner cancellous bone region of the bone further comprises inserting an introducer through the outer cortical bone region of the bone and within the inner cancellous bone region of the bone and inserting the distal end portion of the radiofrequency energy delivery device through the introducer.
7. The method of claim 1 , wherein the bone comprises a vertebral body, and wherein the nerve comprises a basivertebral nerve.
8. A method of treating back pain from a location within a bone of a spine, comprising:
inserting a cannula through an outer cortical bone region of the bone and into the inner cancellous bone region of the bone;
inserting an energy delivery device within the cannula, the energy delivery device having two electrodes positioned along a distal end of the energy delivery device;
advancing the distal end of the energy delivery device out of a distal opening of the cannula and into the inner cancellous bone region of the bone;
positioning a first electrode of the two electrodes on a first side of a nerve within the inner cancellous bone region of the bone and positioning a second electrode of the two electrodes on a second side of the nerve within the inner cancellous bone region of the bone; and
causing a current to be generated between the two electrodes to generate heat sufficient to denervate at least a portion of the nerve within the inner cancellous bone region of the bone.
9. The method of claim 8 , wherein said energy delivery device is a bipolar radiofrequency energy delivery probe.
10. The method of claim 9 , wherein the two electrodes comprise an active electrode at a distal tip of the bipolar radiofrequency energy delivery probe and a return electrode spaced proximal to the active electrode.
11. The method of claim 10 , further comprising providing cooling to the active electrode.
12. The method of claim 10 , wherein the cannula comprises a curved bore.
13. The method of claim 8 , wherein the bone comprises a vertebral body.