IP Library Granted Patent US 12,222,267
Granted Patent B2
US 12,222,267 · App. 15/734,489 · Granted Feb 11, 2025

Analysis device and method for analyzing a viscosity of a fluid

Inventors: Ingo Stotz (Ditzingen, DE); Thomas Alexander Schlebusch (Renningen, DE); Tobias Schmid (Stuttgart, DE)
Assignee: KARDION GMBH
G01N11/04A61M60/174A61M60/216A61M60/422G01N33/49G01N2011/0073
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Quick Facts
Patent No.
US 12,222,267
App. No.
15/734,489
Granted
Feb 11, 2025
Kind
B2
Abstract

The approach presented here relates to an analysis device ( 100 ) for analyzing a viscosity of a fluid ( 217 ). The analysis device ( 100 ) comprises a detection device ( 110 ) and a provisioning device ( 115 ). The detection device ( 110 ) is formed to determine the viscosity of the fluid ( 217 ) using at least one Doppler parameter of a Doppler spectrum of the fluid ( 217 ). The provisioning device ( 115 ) is formed to provide or transmit a viscosity signal that represents the viscosity determined by the detection device ( 110 ).

Claims (72)

1. A cardiac assist system comprising:

an inlet interface having inlet openings;

an outlet interface having outlet openings;

a flow machine comprising:

an impeller coupled to an electric motor;

a connection cable; and

a cannula through which a blood flow can be conveyed by the flow machine from the inlet interface to the outlet interface, the cannula configured to extend along an axis across a patient's aortic valve and be coupled to the connection cable, wherein a tip of the cannula is located at a distal end of the cannula; and

an analysis device configured to analyze a viscosity of blood in a blood flow of the patient, the analysis device comprising:

an ultrasonic element arranged in the tip and configured to generate a sound wave in the blood, wherein the sound wave radiates through the inlet interface into the cannula along the axis and reflects off the blood,

a detection device configured to determine the viscosity of the blood using at least one Doppler parameter of a Doppler spectrum of the sound wave reflected off the blood, wherein the detection device is configured to determine the viscosity using a functional relationship between the Doppler Parameter and the viscosity; and

a provisioning device configured to provide a viscosity signal representing the viscosity of the blood that is detected by the detection device.

2. The cardiac assist system of claim 1 , wherein the detection device is configured to determine the viscosity using a lookup table.

3. The cardiac assist system of claim 2 , wherein the lookup table comprises values characterizing a relationship between the Doppler parameter and the viscosity.

4. The cardiac assist system of claim 2 , wherein the lookup table comprises an interpolation of a first viscosity and a second viscosity and wherein the detection device is configured to determine the viscosity using the interpolation of the first viscosity and the second viscosity.

5. The cardiac assist system of claim 1 , wherein the detection device is configured to determine the viscosity using at least one cannula parameter (r) of the cannula.

6. The cardiac assist system of claim 1 , wherein the flow device is arranged at the outlet interface.

7. The cardiac assist system of claim 1 , wherein the detection device is configured to determine the viscosity using at least one flow parameter of a flow profile.

8. The cardiac assist system of claim 7 , wherein the at least one flow parameter comprises a flow velocity (v) of the fluid through the cannula.

9. The cardiac assist system of claim 1 , wherein the detection device is configured to determine the viscosity using the Doppler parameter and wherein the Doppler parameter comprises a Doppler frequency or a width of the Doppler spectrum.

10. A method for analyzing a viscosity of blood in a bloodstream of a patient conveyed by a flow device through a cannula which is extended along an axis, the method comprising:

generating a sound wave in the blood by an ultrasonic element, wherein the sound wave radiates through an inlet area of an inlet interface of the cannula and into the cannula along its axis and reflects off the blood; and

determining the viscosity of the blood in the bloodstream using at least one Doppler parameter of a Doppler spectrum, wherein determining the viscosity comprises applying a functional relationship between the Doppler parameter and the viscosity.

11. The method of claim 10 , wherein determining the viscosity comprises using a lookup table to determine the viscosity based on the Doppler parameter.

12. The method of claim 11 , wherein the lookup table comprises values characterizing a relationship between the Doppler parameter and the viscosity.

13. The method of claim 11 , wherein the lookup table comprises an interpolation of a first viscosity and a second viscosity and wherein the detection device is configured to determine the viscosity using the interpolation of the first viscosity and the second viscosity.

14. The method of claim 10 , wherein determining the viscosity comprises using at least one cannula parameter (r) of the cannula.

15. The method of claim 10 , wherein determining the viscosity comprises using at least one flow parameter of a flow profile.

16. The method of claim 15 , wherein the at least one flow parameter comprises a flow velocity (v) of the fluid through the cannula.

17. The method of claim 10 , wherein the at least one Doppler parameter comprises a Doppler frequency or a width of the Doppler spectrum.

18. A cardiac assist system comprising:

an inlet interface having inlet openings;

an outlet interface having outlet openings;

a flow machine comprising:

an impeller coupled to an electric motor;

a connection cable; and

a cannula through which a blood flow can be conveyed by the flow machine from the inlet interface to the outlet interface, the cannula configured to extend along an axis across a patient's aortic valve and be coupled to the connection cable, wherein a tip of the cannula is located at a distal end of the cannula; and

an analysis device configured to analyze a viscosity of blood in a blood flow of the patient, the analysis device comprising:

an ultrasonic element arranged in the tip and configured to generate a sound wave in the blood, wherein the sound wave radiates through the inlet interface into the cannula along the axis and reflects off the blood,

a detection device configured to determine the viscosity of the blood using at least one Doppler parameter of a Doppler spectrum of the sound wave reflected off the blood, wherein the detection device is configured to determine the viscosity using a lookup table; and

a provisioning device configured to provide a viscosity signal representing the viscosity of the blood that is detected by the detection device.

19. The cardiac assist system of claim 18 , wherein the lookup table comprises values characterizing a relationship between the Doppler parameter and the viscosity.

20. The cardiac assist system of claim 18 , wherein the lookup table comprises an interpolation of a first viscosity and a second viscosity and wherein the detection device is configured to determine the viscosity using the interpolation of the first viscosity and the second viscosity.

21. A cardiac assist system comprising:

an inlet interface having inlet openings;

an outlet interface having outlet openings;

a flow machine comprising:

an impeller coupled to an electric motor;

a connection cable; and

a cannula through which a blood flow can be conveyed by the flow machine from the inlet interface to the outlet interface, the cannula configured to extend along an axis across a patient's aortic valve and be coupled to the connection cable, wherein a tip of the cannula is located at a distal end of the cannula; and

an analysis device configured to analyze a viscosity of blood in a blood flow of the patient, the analysis device comprising:

an ultrasonic element arranged in the tip and configured to generate a sound wave in the blood, wherein the sound wave radiates through the inlet interface into the cannula along the axis and reflects off the blood,

a detection device configured to determine the viscosity of the blood using at least one Doppler parameter of a Doppler spectrum of the sound wave reflected off the blood, wherein the detection device is configured to determine the viscosity using at least one cannula parameter (r) of the cannula; and

a provisioning device configured to provide a viscosity signal representing the viscosity of the blood that is detected by the detection device.

22. A cardiac assist system comprising:

an inlet interface having inlet openings;

an outlet interface having outlet openings;

a flow machine comprising:

an impeller coupled to an electric motor;

a connection cable; and

a cannula through which a blood flow can be conveyed by the flow machine from the inlet interface to the outlet interface, the cannula configured to extend along an axis across a patient's aortic valve and be coupled to the connection cable, wherein a tip of the cannula is located at a distal end of the cannula; and

an analysis device configured to analyze a viscosity of blood in a blood flow of the patient, the analysis device comprising:

an ultrasonic element arranged in the tip and configured to generate a sound wave in the blood, wherein the sound wave radiates through the inlet interface into the cannula along the axis and reflects off the blood,

a detection device configured to determine the viscosity of the blood using at least one Doppler parameter of a Doppler spectrum of the sound wave reflected off the blood, wherein the detection device is configured to determine the viscosity using the Doppler parameter and wherein the Doppler parameter comprises a Doppler frequency or a width of the Doppler spectrum; and

a provisioning device configured to provide a viscosity signal representing the viscosity of the blood that is detected by the detection device.

23. A method for analyzing a viscosity of blood in a bloodstream of a patient conveyed by a flow device through a cannula which is extended along an axis, the method comprising:

generating a sound wave in the blood by an ultrasonic element, wherein the sound wave radiates through an inlet area of an inlet interface of the cannula and into the cannula along its axis and reflects off the blood; and

determining the viscosity of the blood in the bloodstream using at least one Doppler parameter of a Doppler spectrum, wherein determining the viscosity comprises using a lookup table to determine the viscosity based on the Doppler parameter.

24. The method of claim 21 , wherein the lookup table comprises values characterizing a relationship between the Doppler parameter and the viscosity.

25. The method of claim 21 , wherein the lookup table comprises an interpolation of a first viscosity and a second viscosity and wherein the detection device is configured to determine the viscosity using the interpolation of the first viscosity and the second viscosity.

26. A method for analyzing a viscosity of blood in a bloodstream of a patient conveyed by a flow device through a cannula which is extended along an axis, the method comprising:

generating a sound wave in the blood by an ultrasonic element, wherein the sound wave radiates through an inlet area of an inlet interface of the cannula and into the cannula along its axis and reflects off the blood; and

determining the viscosity of the blood in the bloodstream using at least one Doppler parameter of a Doppler spectrum, wherein the at least one Doppler parameter comprises a Doppler frequency or a width of the Doppler spectrum.

Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 21, 2022
From: ROBERT BOSCH GMBH
To: KARDION GMBH
Reel/Frame 058730/0375 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 20, 2022
From: STOTZ, INGO; SCHLEBUSCH, THOMAS ALEXANDER; SCHMID, TOBIAS
To: ROBERT BOSCH GMBH
Reel/Frame 058712/0282 →
SECURITY INTEREST Recorded Apr 26, 2021
From: KARDION GMBH
To: EDWARDS LIFESCIENCES HOLDING, INC.
Reel/Frame 056046/0422 →
Priority Claims (1)
DE 102018208945.0 · Jun 6, 2018 · national
Continuity (1)
Related Publication 20220050037A1 · Feb 17, 2022
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