Method and system for reducing the likelihood of osteoporosis
Various embodiments of the present invention are directed to the field of treating and preventing osteoporosis, with particular embodiments directed to a method of ameliorating, treating, or preventing osteoporosis in a human subject employing tomatidine, xylitol, rapamycin, etc., as well as modifying an individual's microbiome to reduce the likelihood of osteoporosis.
1. A method for reducing the likelihood of osteoporosis in an individual human being, said method comprising: substantially reducing the human being's resident populations of gut microbes prior to administering a therapeutically effective amount of a bacterial formulation comprising Coprococcus ; and providing fructan fiber inulin in an amount sufficient to reduce the pH in the colon of the human being to achieve acidifying of the colon, wherein the bacteria formulation includes bacteria that have been modified to increase the level of butyrate in the human being's gut by the bacterial formulation.
2. The method of claim 1 , wherein the beneficial formulation is encapsulated.
3. The method of claim 1 , wherein the Coprococcus bacteria employed are first isolated from a human being's stool and where the Coprococcus bacteria are from the human being treated.
4. The method of claim 1 , further comprising administering tomatidine to the human being.
5. The method of claim 1 , wherein the bacterial formulation comprises bacteria modified via a clustered regularly interspaced short palindromic repeats (CRISPR) CRISPR associated protein (Cas) system or a CRISPR from Prevotella and Francisella 1(Cpf1) system.
6. The method of claim 1 , further comprising reducing bacteria in the gut of the human being, wherein the bacteria reduced are selected from the group consisting of Pediococcus, Streptococcus, Enterococcus , and Leuconostoc bacteria.
7. The method of claim 6 , wherein the step of reducing the number of bacteria comprises administering an antibiotic.
8. The method as set forth in claim 6 , further comprising reducing the number of bacteria in the human being's gut using a clustered regularly interspaced short palindromic repeats (CRISPR) CRISPR associated protein (Cas) system or a CRISPR from Prevotella and Francisella 1(Cpf1) system.
9. The method of claim 1 , wherein the bacterial formulation further comprises a bacterium selected from the group consisting of Chlamydia, Shigella flexneri, Mycoplasma bacteria, Lactobacillus casei, Roseburia, Bifidobacterium , and Faecalibacterium prausnitzii.
10. The method of claim 1 , further comprising increasing the levels of bacterial genera selected from the group consisting of Bifidobacterium, Lachnospira, Roseburia, Lactobacillus and Shigella.
11. A method for reducing the likelihood of developing osteoporesis in an individual, comprising: providing in the gut of an individual bacteria from a population of beneficial bacteria selected from the group consisting of Coprococcus, Roseburia, Bifidobacterium , and Faecalibacterium prausnitzii ; and administering fiber to the individual to maintain a therapeutically effective amount of the beneficial bacteria in the gut of the individual; and administering to the individual at least 10 micro-mole of tomatidine.
12. The method as set forth in claim 11 , further comprising, providing in the gut of the individual bacteria selected from the group consisting of Lactobacillus species; administering at least 6 grams per day of fiber to the individual to maintain a therapeutically effective amount of the beneficial bacteria in the gut of the individual human being; and increasing the levels of at least one of Roseburia and Faecalibacterium prausnitzii in the individual's gut microbiome.
13. The method as set forth in claim 11 , further comprising reducing the number of bacteria in the human being using a clustered regularly interspaced short palindromic repeats (CRISPR) CRISPR associated protein (Cas) system or a CRISPR from Prevotella and Francisella 1(Cpf1) system.
14. The method as set forth in claim 11 , further comprising increasing the levels of bacteria in the individual selected from the group consisting of Bifidobacterium, Prevotella, Lachnospira , and Shigella.
15. The method as set forth in claim 11 , wherein said beneficial bacteria have been modified by using a clustered regularly interspaced short palindromic repeats (CRISPR) CRISPR associated protein (Cas) system or a CRISPR from Prevotella and Francisella 1(Cpf1) system.
16. A method for reducing the likelihood of developing osteoporosis in an individual human being, comprising: providing in the gut of an individual a population of beneficial bacteria selected from the group consisting of Faecalibacterium prausnitzii and/or Akkermansia muciniphila ; administering at least 6 grams per day of fiber to the individual to maintain a therapeutically effective amount of the beneficial bacteria in the gut of the individual human being; and administering tomatidine to the individual human being.
17. The method as set forth in claim 16 , further comprising administering to the individual human being a bacteria selected from the group consisting of Streptococcus, Actinomyces, Veillonella, Fusobacterium, Porphyromonas, Prevotella, Treponema, Neisseria Haemophilus, Lactobacillus, Capnocytophaga, Eikenella, Leptotrichia, Peptostreptococcus, Propionibacterium, Chlamydia, Shigella flexneri, Mycoplasma bacteria, H. pylori , and Streptomyces hygroscopicus and selectively reducing in the individual's gut microbiome bacteria selected from the group consisting of Actinomyces , Eggerthella, and Clostridium Cluster XIVa.
18. The method as set forth in claim 16 , further comprising administering at least 0.1 mg of rapamycin.
19. The method of claim 16 , wherein said administering of tomatidine step comprises providing the individual with a bioadhesive strip having a first and second side, the second side having a bioadhesive that is adapted to bind to a mucosal membrane for at least 1 hour while inside a person's mouth, said strip including at least one polymer selected from the group consisting of pullulan, hydroxypropylmethyl cellulose, hydroxyethyl cellulose, sodium alginate, polyethylene glycol, tragacanth gum, guar gum, acacia gum, arabic gum, carboxyvinyl polymer, amylose, high amylose starch, hydroxypropylated high amylose starch, dextrin, chitin, chitosan, levan, elsinan, collagen, zein, gluten, soy protein isolate, whey protein isolate, casein and mixtures thereof; wherein said strip includes tomatidine.