Ketone body esters of s-beta-hydroxybutyrate and/or s-1,3-butanediol for modifying metabolic function
Compositions and methods for producing elevated blood levels of ketone bodies and modifying metabolic function in a mammal. Compositions include at least one ester of S-beta-hydroxybutyrate and/or a mono- or di-ester of S-1,3-butanediol and at least one ketone body component. The ketone body component includes beta-hydroxybutyrate, acetoacetate, or both. The beta-hydroxybutyrate is R-beta-hydroxybutyrate, S-beta-hydroxybutyrate, or both. When the ketone body component is S-beta-hydroxybutyrate, the 1,3-butanediol is R-1,3-butanediol, S-1,3-butanediol, or both. Compositions may comprise a keto stack of multiple forms of ketone bodies.
1. A composition for increasing ketone body level and modify metabolic function in a subject, the composition comprising:
a mono- or di-ester of:
a ketone body component selected from beta-hydroxybutyrate, acetoacetate, or both; and
S-1,3-butanediol; and
at least one ketone body salt selected from the group consisting of beta-hydroxybutyrate salts and acetoacetate salts.
2. The composition of claim 1 , wherein the ketone body component includes R-beta-hydroxybutyrate.
3. The composition of claim 1 , wherein the ketone body component is enriched in R-beta-hydroxybutyrate relative to S-beta-hydroxybutyrate.
4. The composition of claim 1 , wherein the ketone body component includes S-beta-hydroxybutyrate.
5. The composition of claim 1 , wherein the ketone body component is enriched in S-beta-hydroxybutyrate relative to R-beta-hydroxybutyrate.
6. The composition of claim 1 , wherein the composition comprises a di-ester having two beta-hydroxybutyrate compounds bonded to the S-1,3-butanediol.
7. The composition of claim 6 , wherein both of the beta-hydroxybutyrate compounds are R-beta-hydroxybutyrate.
8. The composition of claim 6 , wherein both of the beta-hydroxybutyrate compounds are S-beta-hydroxybutyrate.
9. The composition of claim 6 , wherein one of the beta-hydroxybutyrate compounds is R-beta-hydroxybutyrate and another one is S-beta-hydroxybutyrate.
10. The composition of claim 1 , wherein the composition comprises a di-ester having two acetoacetate compounds bonded to the S-1,3-butanediol.
11. The composition of claim 1 , wherein the composition comprises a di-ester having a beta-hydroxybutyrate and an acetoacetate bonded to the S-1,3-butanediol.
12. The composition of claim 11 , wherein the beta-hydroxybutyrate is R-beta-hydroxybutyrate.
13. The composition of claim 11 , wherein the beta-hydroxybutyrate is S-beta-hydroxybutyrate.
14. The composition of claim 1 , wherein the composition includes a mixture of ketone body components that form the mono- or di-ester such that about 55% to about 95% by weight of ketone bodies of the ketone body component are beta-hydroxybutyrate and about 5% to about 45% by weight are acetoacetate.
15. The composition of claim 1 , wherein the at least one ketone body salt includes at least one of a sodium salt, potassium salt, magnesium salt, calcium salt, amino acid salt, or combination thereof.
16. The composition of claim 1 , further comprising a carrier, the carrier comprising a powder, liquid, gel, suspension, tablet, capsule, food product, food additive, beverage, beverage additive, or food supplement.
17. The composition of claim 1 , further comprising a short or medium chain fatty acid, or a mono-, di- or triglyceride of the short or medium chain fatty acid.
18. A composition for increasing ketone body level and modify metabolic function in a subject, the composition comprising:
a mono- or di-ester of:
S-beta-hydroxybutyrate; and
1,3-butanediol; and
at least one of:
at least one ketone body salt selected from the group consisting of beta-hydroxybutyrate salts and acetoacetate salts, or
at least one ketone body acid selected from the group consisting of beta-hydroxybutyric acid and acetoacetic acid.
19. A stacked composition for increasing ketone body level and modify metabolic function in a subject, the composition comprising:
at least one ester selected from:
an ester of S-beta-hydroxybutyrate; or
an ester of S-1,3-butanediol and at least one ketone body; and
at least one of:
one or more ketone body salts selected from the group consisting of beta-hydroxybutyrate salts and acetoacetate salts, or
one or more ketone body acids selected from the group consisting of beta-hydroxybutyric acid and acetoacetic acid.
20. The composition of claim 18 in a dosage form for oral consumption, wherein the dosage form is selected from the group consisting of powder, liquid, gel, suspension, tablet, capsule, food product, food additive, beverage, beverage additive, and food supplement and provides an oral dose of ketone bodies in a range of about 0.5 gram to about 50 grams.
21. A composition for increasing ketone body level and modifying metabolic function in a subject, the composition comprising:
at least one ester or ester mixture selected from:
an ester of S-beta-hydroxybutyrate or a non-racemic ester mixture enriched in S-beta-hydroxybutyrate relative to R-beta-hydroxybutyrate; or
an ester of S-1,3-butanediol or a non-racemic ester mixture enriched in S-1,3-butanediol relative to R-1,3-butanediol; and
at least one of:
one or more ketone body salts selected from the group consisting of beta-hydroxybutyrate salts and acetoacetate salts, or
one or more ketone body acids selected from the group consisting of beta-hydroxybutyric acid and acetoacetic acid.