IP Library › Granted Patent US 11,925,818
Granted Patent B2
US 11,925,818 · App. 17/399,415 · Granted Mar 12, 2024

Flash proton therapy apparatus and method of use thereof

Inventors: Susan L. Michaud (Brewster, MA); Daniel J. Raymond (Windham, NH)
A61N5/1077A61B6/03A61N5/1044A61N5/1067A61N5/1082G21K1/087G21K1/093G21K5/04A61N5/107A61N2005/1074A61N2005/1087A61N2005/1097H01J35/147
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Quick Facts
Patent No.
US 11,925,818
App. No.
17/399,415
Filed
Aug 11, 2021
Granted
Mar 12, 2024
Kind
B2
Art Unit
2881
USPC
600/1
Abstract

The invention comprises a method and apparatus for treating a tumor of a patient with positively charged particles, comprising the steps of: (1) transporting the positively charged particles sequentially from an accelerator, through a beam transport line, through a nozzle, and toward a position of the tumor; (2) treating the tumor with first particles, of the positively charged particles, where at least fifty percent of the first particles pass through a patient position, from the nozzle, to a post-patient position; and (3) detecting a beam position of the first particles in the post-patient position with a detector. The flash treatment preferably delivers the first particles at a rate exceeding one MHz.

Claims (59)

1. A method for treating a tumor of a patient with positively charged particles, comprising the steps of:

transporting the positively charged particles sequentially from an accelerator, through a beam transport line, through a nozzle, and toward a position of the tumor;

treating the tumor with first particles, of the positively charged particles, wherein at least fifty percent of the first particles pass through a patient position, from said nozzle, to a post-patient position; and

detecting a beam position of the first particles in said post-patient position with a detector.

2. The method of claim 1 , said step of treating further comprising the step of:

delivering the first particles at a rate exceeding one MHz.

3. The method of claim 2 , said step of detecting further comprising the step of:

determining said beam position with an organic film charged particle detector.

4. The method of claim 2 , said step of treating further comprising the step of:

delivering second particles, of the positively charged particles, to said tumor, said second particles comprising a Bragg peak position in the tumor.

5. The method of claim 4 , further comprising the steps of:

said step of detecting further comprising the step of passing the passing the positively charged particles through a first time of flight detector element and at least into a second time of flight detector element;

receiving, into a beam state determination system, (1) a first signal related to an initial time of passage of the positively charged particles through said first time of flight detector and (2) a second signal related to an arrival time of the positively charged particles to said second time of flight detector element;

in a step of imaging the patient:

calculating a residual velocity of the positively charged particle after passing through the patient;

determining a velocity of the positively charged particle using a distance between the first time of flight detector element and the second time of flight detector element; and

determining an energy of the positively charged particle using the first signal, the arrival time, and a pathlength of the positively charged particles between the first time of flight detector and the second time of flight detector.

6. The method of claim 4 , said step of transporting further comprising the step of:

slowing the positively charged particles in an extraction step of moving said positively charged particles from said accelerator to said beam transport line.

7. The method of claim 1 , further comprising the step of:

verifying alignment of the first particles on a tumor position with said beam position.

8. The method of claim 1 , said step of detecting further comprising the steps of:

detecting a missed treatment voxel of the tumor; and

treating said missed treatment voxel in accordance to a prescribed treatment.

9. The method of claim 1 , further comprising the steps of:

accelerating the positively charged particles to a current relativistic energy using said accelerator;

said step of transporting passing the positively charged particles through the patient to yield a residual particle beam comprising a residual relativistic velocity;

determining the residual relativistic velocity using a first time of flight detector and a second time of flight detector separated by a separation distance; and

generating a positively charged particle computed tomography image with at least one of:

the residual relativistic velocity;

an increased mass of the positively charged particles determined using the residual relativistic velocity; and

an energy of the residual particle beam associated with the residual relativistic velocity,

wherein individual particles in the residual particle beam comprise a second mass of at least 1.02 times that of the individual particles prior to said step of accelerating.

10. The method of claim 1 , said step of detecting further comprising the steps of:

passing the positively charged particles into a multi-layer detector element;

detecting first secondary photons, resultant from passage of the positively charged particles, over a first wavelength range from a first layer of said multi-layer detector, said first layer comprising a first scintillation material; and

detecting second secondary photons, resultant from passage of the positively charged particles, over a second wavelength range from a second layer of said multi-layer detector element, the first wavelength range differing from the second wavelength range.

11. The method of claim 1 , further comprising the steps of:

using a double dipole scanning system, in said nozzle, to scan the positively charged particles along a first axis and a second axis, said double dipole scanning system comprising:

a beam path chamber comprising an entrance side and an exit side, the entrance side comprising a smaller area than the exit side,

a first dipole magnet, said first dipole magnet comprising a first coil and a third coil on first opposite sides of said beam path chamber; and

a second dipole magnet, said second dipole magnet comprising a second coil and a fourth coil on second opposite sides of said beam path chamber;

scanning the charged particles along the first axis with said first dipole magnet; and

scanning the charged particles along the second axis with said second dipole magnet.

12. The apparatus of claim 1 , said nozzle further comprising:

a dual axis scanning system; comprising:

a first pair of magnets;

a second pair of magnets; and

a beam path chamber comprising an entrance side and an exit side, said entrance side comprising a smaller area than the exit side,

wherein said first pair of magnets and said second pair of magnets circumferentially surround a common volume of a longitudinal axis of said beam path chamber.

13. An apparatus for treating a tumor of a patient with positively charged particles, comprising:

a cancer therapy system comprising a transport path of the positively charged particles sequentially passing from an accelerator, through a beam transport line, through a nozzle, and toward a position of the tumor; and

a detector positioned in a post-patient position relative to a treatment path from said nozzle passing through the patient position, said detector configured to detect a position of first particles, of the positively charged particles, in said post-patient position, wherein at least fifty percent of the first particles pass from said nozzle, through the patient position, to said detector, where said first particles flash treat the tumor.

14. The apparatus of claim 13 , said detector further comprising:

an organic film charged particle detector comprising germanium.

15. The apparatus of claim 13 , further comprising:

a winding about a core of a magnet about said beam transport line, said winding comprising:

a first width and a first thickness at a first cross-sectional position of said winding; and

a second width at least fifty percent larger than said first width and a second thickness less than half said first thickness at a second cross-sectional position of said winding.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 15, 2023
From: MICHAUD, SUSAN L; RAYMOND, DANIEL J
To: PROTOM INTERNATIONAL HOLDING CORPORATION
Reel/Frame 062379/0034 →
Continuity (20)
Continuation In Part 17383836 · Jul 23, 2021
Continuation In Part 17382044 · Jul 21, 2021
Continuation In Part 16903736 · Jun 17, 2020
Continuation In Part 16533761 · Aug 6, 2019
Continuation In Part 15901788 · Feb 21, 2018
Continuation In Part 15892240 · Feb 8, 2018
Continuation In Part 15838072 · Dec 11, 2017
Continuation In Part 15823148 · Nov 27, 2017
Continuation In Part 15467840 · Mar 23, 2017
Continuation In Part 15402739 · Jan 10, 2017
Continuation In Part 15348625 · Nov 10, 2016
Continuation In Part 15167617 · May 27, 2016
Continuation In Part 15868897 · Jan 11, 2018
Continuation 15152479 · May 11, 2016
Continuation In Part 14216788 · Mar 17, 2014
Continuation In Part 13087096 · Apr 14, 2011
Provisional Application 61324776 · Apr 16, 2010
Provisional Application 63174131 · Apr 13, 2021
Provisional Application 63174157 · Apr 13, 2021
Related Publication 20210370101A1 · Dec 2, 2021
Cited By (3)
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