IP Library › Granted Patent US 12,449,674
Granted Patent B2
US 12,449,674 · App. 17/455,879 · Granted Oct 21, 2025

Contact lens with a hydrophilic layer

Inventors: Karen L. Havenstrite (Saratoga, CA); Victor Wayne McCray (San Jose, CA); Brandon McNary Felkins (Half Moon Bay, CA); Douglas Michael Ackermann (San Francisco, CA); Garrett Cale Smith (San Francisco, CA); Paul A. Cook (Palo Alto, CA); Evan S. Luxon (San Francisco, CA); Andrew A. McGibbon (San Francisco, CA)
Assignee: Tangible Science, Inc.
G02C7/049C08L5/08C08L71/00C09D105/08C09D171/00G02B1/043C08L2203/02C08L2205/025G02C2202/16
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 12,449,674
App. No.
17/455,879
Granted
Oct 21, 2025
Kind
B2
Abstract

Embodiments of the technology relate to a contact lens having a core that is covalently coated by a hydrogel layer, and to methods of making such a lens. In one aspect, embodiments provide for a coated contact lens comprising a lens core comprising an outer surface; and a hydrogel layer covalently attached to at least a portion of the outer surface, the hydrogel layer adapted to contact an ophthalmic surface, wherein the hydrogel layer comprises a hydrophilic polymer population having a first PEG species and a second PEG species, the first PEG species being at least partially cross-linked to the second PEG species.

Claims (30)

1. A method of making a hydrogel coated contact lens comprising:

reacting an outer surface of a contact lens with a first polymer species of a hydrophilic polymer solution,

wherein the first polymer species comprises an electron pair accepting moiety and a first portion of the electron pair accepting moiety forms a covalent attachment to the outer surface of the contact lens through a first nucleophilic conjugate reaction; and

reacting the first polymer species of the hydrophilic polymer solution with a second polymer species of the hydrophilic polymer solution,

wherein the second polymer species comprises a nucleophilic reactive moiety adapted to covalently link to a second portion of the electron pair accepting moiety of the first polymer species in a second nucleophilic conjugate reaction to at least partially cross-link the first polymer species and second polymer species,

wherein the first and second nucleophilic conjugate reactions are 1,4-nucleophilic addition reactions, and

wherein a hydrogel coating is formed and covalently attached to the outer surface of the contact lens by the first and second nucleophilic conjugate reactions.

2. The method of claim 1 , further comprising modifying the outer surface of the contact lens to form a plurality of reactive nucleophilic sites on the outer surface.

3. The method of claim 2 , wherein the modifying step comprises exposing the outer surface of the contact lens to a gas plasma treatment.

4. The method of claim 2 , wherein reacting the outer surface of the contact lens with the first polymer species comprises reacting at least a portion of the plurality of reactive nucleophilic sites on the outer surface with the first portion of the electron pair accepting moiety on the first polymer species.

5. The method of claim 1 , wherein the first and second nucleophilic conjugate reactions are both a Michael-type reaction.

6. The method of claim 1 , wherein both of the first and second nucleophilic conjugate reactions are click reactions.

7. The method of claim 1 , wherein the nucleophilic reactive moiety of the second polymer species is an amine group and the electron pair accepting moiety of the first polymer species is a carboxyl group, such that the first polymer species and the second polymer species are cross-linked through an amide moiety.

8. The method of claim 1 , wherein the hydrophilic polymer solution comprises substantially equivalent concentrations of the first polymer species and the second polymer species.

9. The method of claim 1 , wherein a concentration of the electron pair accepting moiety of the first polymer species exceeds a concentration of the nucleophilic reactive moiety of the second polymer species by about 1% to about 30%.

10. The method of claim 1 , wherein the reacting steps are performed at a temperature between about 20 degrees Celsius and about 40 degrees Celsius.

11. The method of claim 1 , wherein the reacting steps are performed at a pH between about 7 and about 11.

12. The method of claim 1 , wherein the hydrogel coating is substantially optically clear.

13. The method of claim 1 , wherein the contact lens comprises a core consisting of silicone.

14. The method of claim 1 , wherein the contact lens comprises a core comprising silicone.

15. The method of claim 1 , wherein the contact lens comprises a hydrogel core.

16. The method of claim 1 , wherein the first and second polymer species are selected from the group consisting of: polyethylene glycol (PEG), phosphorylcholine, poly(vinyl alcohol), poly(vinylpyrrolidinone), poly(N-isopropylacrylamide) (PNIPAM), polyacrylamide (PAM), poly(2-oxazoline), polyethylenimine (PEI), poly(acrylic acid), polymethacrylate, polyelectrolytes, hyaluronic acid, chitosan, and dextran.

17. The method of claim 1 , wherein the hydrogel coating layer comprises a thickness between about 0.01 microns and about 0.05 microns.

18. A method of making a hydrogel coated contact lens comprising:

reacting an outer surface of a contact lens with a first polymer species of a hydrophilic polymer solution,

wherein the first polymer species comprises an electron pair accepting moiety and a first portion of the electron pair accepting moiety forms a covalent attachment to the outer surface of the contact lens through a first nucleophilic conjugate reaction; and

reacting the first polymer species of the hydrophilic polymer solution with a second polymer species of the hydrophilic polymer solution,

wherein the second polymer species comprises a nucleophilic reactive moiety adapted to covalently link to a second portion of the electron pair accepting moiety of the first polymer species in a second nucleophilic conjugate reaction to at least partially cross-link the first polymer species and second polymer species,

wherein the first and second nucleophilic conjugate reactions are Michael-type reactions, and

wherein a hydrogel coating is formed and covalently attached to the outer surface of the contact lens by the first and second nucleophilic conjugate reactions.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 30, 2024
From: HAVENSTRITE, KAREN L.; MCCRAY, VICTOR WAYNE; FELKINS, BRANDON MCNARY; ACKERMANN, DOUGLAS MICHAEL; SMITH, GARRETT CALE; COOK, PAUL A.; LUXON, EVAN S.; MCGIBBON, ANDREW A.
To: TANGIBLE SCIENCE, INC.
Reel/Frame 069076/0578 →
Continuity (8)
Continuation 16593664 · Oct 4, 2019
Continuation 15206103 · Jul 8, 2016
Continuation 13975868 · Aug 26, 2013
Provisional Application 61834813 · Jun 13, 2013
Provisional Application 61800835 · Mar 15, 2013
Provisional Application 61800959 · Mar 15, 2013
Provisional Application 61693689 · Aug 27, 2012
Related Publication 20220075208A1 · Mar 10, 2022
References Cited (370)
US 2976576A · Wichterle et al. · 1961 [cited by applicant]
US 3408429A · Otto · 1968 [cited by applicant]
US 4136250A · Mueller et al. · 1979 [cited by applicant]
US 4143949A · Chen · 1979 [cited by applicant]
US 4153641A · Deichert et al. · 1979 [cited by applicant]
US 4182822A · Chang · 1980 [cited by applicant]
US 4189546A · Deichert et al. · 1980 [cited by applicant]
US 4254248A · Friends et al. · 1981 [cited by applicant]
US 4259467A · Keogh et al. · 1981 [cited by applicant]
US 4260725A · Keogh et al. · 1981 [cited by applicant]
US 4261875A · Leboeuf · 1981 [cited by applicant]
US 4276402A · Chromecek et al. · 1981 [cited by applicant]
US 4327203A · Deichert et al. · 1982 [cited by applicant]
US 4338419A · Korb et al. · 1982 [cited by applicant]
US 4341889A · Deichert et al. · 1982 [cited by applicant]
US 4343927A · Chang · 1982 [cited by applicant]
US 4347198A · Ohkada et al. · 1982 [cited by applicant]
US 4355147A · Deichert et al. · 1982 [cited by applicant]
US 4444711A · Schad · 1984 [cited by applicant]
US 4460534A · Boehm et al. · 1984 [cited by applicant]
US 4468229A · Su · 1984 [cited by applicant]
US 4486577A · Mueller et al. · 1984 [cited by applicant]
US 4543398A · Bany et al. · 1985 [cited by applicant]
US 4553975A · Su · 1985 [cited by applicant]
US 4605712A · Mueller et al. · 1986 [cited by applicant]
US 4661575A · Tom · 1987 [cited by applicant]
US 4684538A · Klemarczyk · 1987 [cited by applicant]
US 4703097A · Wingler et al. · 1987 [cited by applicant]
US 4833218A · Lee · 1989 [cited by applicant]
US 4837289A · Mueller et al. · 1989 [cited by applicant]
US 4929250A · Hung et al. · 1990 [cited by applicant]
US 4954586A · Toyoshima et al. · 1990 [cited by applicant]
US 4954587A · Mueller · 1990 [cited by applicant]
US 5010141A · Mueller · 1991 [cited by applicant]
US 5034461A · Lai et al. · 1991 [cited by applicant]
US 5039761A · Ono et al. · 1991 [cited by applicant]
US 5070170A · Robertson et al. · 1991 [cited by applicant]
US 5098445A · Hung et al. · 1992 [cited by applicant]
US 5135297A · Valint · 1992 [cited by applicant]
US 5135965A · Tahan · 1992 [cited by applicant]
US 5196458A · Nunez et al. · 1993 [cited by applicant]
US 5219965A · Valint et al. · 1993 [cited by applicant]
US 5260000A · Nandu et al. · 1993 [cited by applicant]
US 5326584A · Kamel et al. · 1994 [cited by applicant]
US 5346946A · Yokoyama et al. · 1994 [cited by applicant]
US 5352714A · Lai et al. · 1994 [cited by applicant]
US 5358995A · Lai et al. · 1994 [cited by applicant]
US 5409731A · Nakagawa et al. · 1995 [cited by applicant]
US 5416132A · Yokoyama et al. · 1995 [cited by applicant]
US 5446090A · Harris · 1995 [cited by applicant]
US 5451617A · Lai et al. · 1995 [cited by applicant]
US 5486579A · Lai et al. · 1996 [cited by applicant]
US 5508317A · Muller · 1996 [cited by applicant]
US 5583463A · Merritt · 1996 [cited by applicant]
US 5645882A · Llanos · 1997 [cited by applicant]
US 5674942A · Hill et al. · 1997 [cited by applicant]
US 5681871A · Molock et al. · 1997 [cited by applicant]
US 5760100A · Nicolson et al. · 1998 [cited by applicant]
US 5805264A · Janssen et al. · 1998 [cited by applicant]
US 5843346A · Morrill · 1998 [cited by applicant]
US 5874500A · Rhee et al. · 1999 [cited by applicant]
US 5894002A · Boneberger et al. · 1999 [cited by applicant]
US 5962548A · Vanderlaan et al. · 1999 [cited by applicant]
US 5981675A · Valint et al. · 1999 [cited by applicant]
US 6019472A · Koester et al. · 2000 [cited by applicant]
US 6022553A · Anders et al. · 2000 [cited by applicant]
US 6039913A · Hirt et al. · 2000 [cited by applicant]
US 6201065B1 · Pathak et al. · 2001 [cited by applicant]
US 6218508B1 · Kragh et al. · 2001 [cited by applicant]
US 6309660B1 · Hsu et al. · 2001 [cited by applicant]
US 6340465B1 · Hsu et al. · 2002 [cited by applicant]
US 6406739B1 · LeBoeuf et al. · 2002 [cited by applicant]
US 6428839B1 · Künzler et al. · 2002 [cited by applicant]
US 6440571B1 · Valint et al. · 2002 [cited by applicant]
US 6447920B1 · Chadbrecek et al. · 2002 [cited by applicant]
US 6451871B1 · Winterton et al. · 2002 [cited by applicant]
US 6458889B1 · Trollsas et al. · 2002 [cited by applicant]
US 6468667B1 · Chabrecek et al. · 2002 [cited by applicant]
US 6478423B1 · Tumer et al. · 2002 [cited by applicant]
US 6500481B1 · Vanderlaan et al. · 2002 [cited by applicant]
US 6623747B1 · Chatelier et al. · 2003 [cited by applicant]
US 6624245B2 · Wallace et al. · 2003 [cited by applicant]
US 6627124B1 · Herbrechtsmeler et al. · 2003 [cited by applicant]
US 6630243B2 · Valint et al. · 2003 [cited by applicant]
US 6638563B2 · McGee et al. · 2003 [cited by applicant]
US 6719929B2 · Winterton et al. · 2004 [cited by applicant]
US 6723815B2 · Callaghan et al. · 2004 [cited by applicant]
US 6740116B2 · Morcher · 2004 [cited by applicant]
US 6759388B1 · Marchant et al. · 2004 [cited by applicant]
US 6762264B2 · Künzler et al. · 2004 [cited by applicant]
US 6793973B2 · Winterton et al. · 2004 [cited by applicant]
US 6800225B1 · Hagmann et al. · 2004 [cited by applicant]
US 6811259B2 · Tucker · 2004 [cited by applicant]
US 6811805B2 · Gilliard et al. · 2004 [cited by applicant]
US 6815074B2 · Aguado et al. · 2004 [cited by applicant]
US 6827966B2 · Qiu et al. · 2004 [cited by applicant]
US 6852353B2 · Qiu et al. · 2005 [cited by applicant]
US 6858248B2 · Qiu et al. · 2005 [cited by applicant]
US 6896926B2 · Qiu et al. · 2005 [cited by applicant]
US 6940580B2 · Winterton et al. · 2005 [cited by applicant]
US 7037517B2 · Kataoka et al. · 2006 [cited by applicant]
US 7053150B2 · Kozlowski et al. · 2006 [cited by applicant]
US 7091283B2 · Müller et al. · 2006 [cited by applicant]
US 7132475B2 · Hubbell et al. · 2006 [cited by applicant]
US 7247387B1 · Huang · 2007 [cited by examiner]
US 7251519B2 · Axelsson et al. · 2007 [cited by applicant]
US 7276474B2 · Marchant et al. · 2007 [cited by applicant]
US 7384590B2 · Kelly et al. · 2008 [cited by applicant]
US 7402318B2 · Morris et al. · 2008 [cited by applicant]
US 7507469B2 · Mao et al. · 2009 [cited by applicant]
US 7642332B2 · Kennedy et al. · 2010 [cited by applicant]
US 7674478B2 · Kataoka et al. · 2010 [cited by applicant]
US 7695775B2 · Kobrin et al. · 2010 [cited by applicant]
US 7744912B1 · Hubbell et al. · 2010 [cited by applicant]
US 7833715B1 · Schweitzer et al. · 2010 [cited by applicant]
US 7847025B2 · Liu et al. · 2010 [cited by applicant]
US 7857447B2 · Myung et al. · 2010 [cited by applicant]
US 7857849B2 · Myung et al. · 2010 [cited by applicant]
US 7858000B2 · Winterton · 2010 [cited by applicant]
US 7942929B2 · Linhardt et al. · 2011 [cited by applicant]
US 7955704B2 · Lowery et al. · 2011 [cited by applicant]
US 8071121B2 · Chauhan et al. · 2011 [cited by applicant]
US 8083348B2 · Linhardt et al. · 2011 [cited by applicant]
US 8133580B2 · Dias et al. · 2012 [cited by applicant]
US 8163302B2 · Marchant et al. · 2012 [cited by applicant]
US 8178602B2 · Mao et al. · 2012 [cited by applicant]
US 8309117B2 · Rubner et al. · 2012 [cited by applicant]
US 8357760B2 · Qiu · 2013 [cited by applicant]
US 8409599B2 · Wu et al. · 2013 [cited by applicant]
US 8425926B2 · Qiu et al. · 2013 [cited by applicant]
US 8480227B2 · Qiu et al. · 2013 [cited by applicant]
US 8790678B2 · Elbert et al. · 2014 [cited by applicant]
US 8871016B2 · Trexler et al. · 2014 [cited by applicant]
US 8871869B2 · Dias et al. · 2014 [cited by applicant]
US 8906284B2 · Crosby et al. · 2014 [cited by applicant]
US 9244195B2 · Bauman et al. · 2016 [cited by applicant]
US 9310627B2 · Havenstrite et al. · 2016 [cited by applicant]
US 9358735B2 · Bothe et al. · 2016 [cited by applicant]
US 9395468B2 · Havenstrite et al. · 2016 [cited by applicant]
US 9395627B2 · Liu et al. · 2016 [cited by applicant]
US 10330951B2 · Havenstrite et al. · 2019 [cited by applicant]
US 10451896B2 · Havenstrite et al. · 2019 [cited by applicant]
US 10525170B2 · Havenstrite et al. · 2020 [cited by applicant]
US 11181754B2 · Havenstrite et al. · 2021 [cited by applicant]
US 11260150B2 · Havenstrite et al. · 2022 [cited by applicant]
US 20010044021A1 · Ogawa et al. · 2001 [cited by applicant]
US 20020006493A1 · Chabrecek et al. · 2002 [cited by applicant]
US 20020057417A1 · Galin · 2002 [cited by applicant]
US 20020086160A1 · Qiu et al. · 2002 [cited by applicant]
US 20020155222A1 · Caron · 2002 [cited by applicant]
US 20030008063A1 · Chabrecek et al. · 2003 [cited by applicant]
US 20030087099A1 · Merill et al. · 2003 [cited by applicant]
US 20040067365A1 · Qiu · 2004 [cited by applicant]
US 20040086479A1 · Grinstaff et al. · 2004 [cited by applicant]
US 20040108607A1 · Winterton et al. · 2004 [cited by applicant]
US 20040116564A1 · Devlin et al. · 2004 [cited by applicant]
US 20040135967A1 · Carey et al. · 2004 [cited by applicant]
US 20040142016A1 · Luthra et al. · 2004 [cited by applicant]
US 20040181172A1 · Carney et al. · 2004 [cited by applicant]
US 20050008676A1 · Qiu et al. · 2005 [cited by applicant]
US 20050031793A1 · Moeller et al. · 2005 [cited by applicant]
US 20050053642A1 · Ulbricht et al. · 2005 [cited by applicant]
US 20050129731A1 · Horres et al. · 2005 [cited by applicant]
US 20060063852A1 · Iwata et al. · 2006 [cited by applicant]
US 20060142479A1 · Weerawarna · 2006 [cited by examiner]
US 20060142481A1 · Herriott · 2006 [cited by examiner]
US 20060275337A1 · Cohen et al. · 2006 [cited by applicant]
US 20060290882A1 · Meyers et al. · 2006 [cited by applicant]
US 20060292701A1 · Huang · 2006 [cited by examiner]
US 20070001155A1 · Walters et al. · 2007 [cited by applicant]
US 20070031498A1 · Zong et al. · 2007 [cited by applicant]
US 20070082019A1 · Huang et al. · 2007 [cited by applicant]
US 20070087113A1 · Uilk et al. · 2007 [cited by applicant]
US 20070116741A1 · Valint et al. · 2007 [cited by applicant]
US 20070122540A1 · Salamone et al. · 2007 [cited by applicant]
US 20070129792A1 · Picart et al. · 2007 [cited by applicant]
US 20070197681A1 · Lowery et al. · 2007 [cited by applicant]
US 20070229758A1 · Matsuzawa · 2007 [cited by applicant]
US 20080002146A1 · Stachowski et al. · 2008 [cited by applicant]
US 20080015315A1 · Chang et al. · 2008 [cited by applicant]
US 20080038221A1 · Suda et al. · 2008 [cited by applicant]
US 20080076851A1 · Goldberg et al. · 2008 [cited by applicant]
US 20080143003A1 · Phelan · 2008 [cited by applicant]
US 20080143958A1 · Medina et al. · 2008 [cited by applicant]
US 20080152685A1 · Blackwell et al. · 2008 [cited by applicant]
US 20080152800A1 · Bothe et al. · 2008 [cited by applicant]
US 20080181931A1 · Qiu et al. · 2008 [cited by applicant]
US 20080203592A1 · Qiu et al. · 2008 [cited by applicant]
US 20080226922A1 · Ferreiro et al. · 2008 [cited by applicant]
US 20080231798A1 · Zhou et al. · 2008 [cited by applicant]
US 20080234457A1 · Zhou et al. · 2008 [cited by applicant]
US 20080255305A1 · Brook · 2008 [cited by examiner]
US 20090060981A1 · Chauhan · 2009 [cited by applicant]
US 20090081275A1 · Rolfes et al. · 2009 [cited by applicant]
US 20090123519A1 · Rolfes et al. · 2009 [cited by applicant]
US 20090155595A1 · Lee · 2009 [cited by applicant]
US 20090280157A1 · Mass et al. · 2009 [cited by applicant]
US 20100013114A1 · Bowers et al. · 2010 [cited by applicant]
US 20100069522A1 · Linhardt et al. · 2010 [cited by applicant]
US 20100099852A1 · Cassingham et al. · 2010 [cited by applicant]
US 20100114042A1 · Dias et al. · 2010 [cited by applicant]
US 20100120938A1 · Phelan et al. · 2010 [cited by applicant]
US 20100140114A1 · Pruitt et al. · 2010 [cited by applicant]
US 20100149482A1 · Ammon et al. · 2010 [cited by applicant]
US 20100152708A1 · Li et al. · 2010 [cited by applicant]
US 20100198168A1 · Rooijmans · 2010 [cited by applicant]
US 20100226963A1 · Cooper et al. · 2010 [cited by applicant]
US 20100239637A1 · Ciolino et al. · 2010 [cited by applicant]
US 20100249273A1 · Scales et al. · 2010 [cited by applicant]
US 20100286377A1 · Schweitzer · 2010 [cited by examiner]
US 20100298446A1 · Chang et al. · 2010 [cited by applicant]
US 20110133350A1 · Qiu et al. · 2011 [cited by applicant]
US 20110134387A1 · Samuel et al. · 2011 [cited by applicant]
US 20110177150A1 · Pathak et al. · 2011 [cited by applicant]
US 20110189493A1 · Ott et al. · 2011 [cited by applicant]
US 20110293669A1 · Bennett et al. · 2011 [cited by applicant]
US 20110293687A1 · Bennett et al. · 2011 [cited by applicant]
US 20110293688A1 · Bennett et al. · 2011 [cited by applicant]
US 20110293692A1 · Bennett et al. · 2011 [cited by applicant]
US 20110293699A1 · Bennett et al. · 2011 [cited by applicant]
US 20120023869A1 · Samuel et al. · 2012 [cited by applicant]
US 20120026457A1 · Qiu et al. · 2012 [cited by applicant]
US 20120026458A1 · Qiu · 2012 [cited by examiner]
US 20120038888A1 · Gu et al. · 2012 [cited by applicant]
US 20120049689A1 · Bennett et al. · 2012 [cited by applicant]
US 20120116019A1 · Suzuki et al. · 2012 [cited by applicant]
US 20120137635A1 · Qiu et al. · 2012 [cited by applicant]
US 20120139137A1 · Qiu · 2012 [cited by applicant]
US 20120147323A1 · Domschke · 2012 [cited by applicant]
US 20130090344A1 · Thakur et al. · 2013 [cited by applicant]
US 20130095235A1 · Bothe et al. · 2013 [cited by applicant]
US 20130118127A1 · Kolluru et al. · 2013 [cited by applicant]
US 20130162943A1 · Goodenough et al. · 2013 [cited by applicant]
US 20130176529A1 · Li et al. · 2013 [cited by applicant]
US 20130188124A1 · Li et al. · 2013 [cited by applicant]
US 20140055741A1 · Havenstrite · 2014 [cited by examiner]
US 20140155313A1 · Eggink et al. · 2014 [cited by applicant]
US 20160161639A1 · Scales et al. · 2016 [cited by applicant]
US 20160320635A1 · Havenstrite · 2016 [cited by examiner]
US 20170160432A1 · Havenstrite et al. · 2017 [cited by applicant]
US 20170242269A1 · Havenstrite et al. · 2017 [cited by applicant]
US 20190310495A1 · Havenstrite et al. · 2019 [cited by applicant]
CN 1180416A · 1998 [cited by applicant]
CN 1233191A · 1999 [cited by applicant]
CN 1543362A · 2004 [cited by applicant]
CN 1602228A · 2005 [cited by applicant]
CN 1961223A · 2007 [cited by applicant]
CN 101096451A · 2008 [cited by applicant]
CN 101688042A · 2010 [cited by applicant]
CN 101726864A · 2010 [cited by applicant]
CN 102323629A · 2012 [cited by applicant]
CN 103254436A · 2013 [cited by applicant]
CN 103547585A · 2014 [cited by applicant]
EP 0807140A1 · 1997 [cited by applicant]
EP 808222B1 · 1999 [cited by applicant]
EP 1251973A1 · 2002 [cited by applicant]
EP 1319037A1 · 2003 [cited by applicant]
EP 0906122B1 · 2003 [cited by applicant]
EP 1412404A1 · 2004 [cited by applicant]
EP 1268621B1 · 2005 [cited by applicant]
EP 0876165B1 · 2006 [cited by applicant]
EP 1744836A2 · 2007 [cited by applicant]
EP 1427532B1 · 2007 [cited by applicant]
EP 0918550B1 · 2007 [cited by applicant]
EP 2061526A2 · 2009 [cited by applicant]
EP 1261557B1 · 2009 [cited by applicant]
EP 1458797B1 · 2009 [cited by applicant]
EP 2187980A1 · 2010 [cited by applicant]
EP 2219865A2 · 2010 [cited by applicant]
EP 2389895A2 · 2011 [cited by applicant]
EP 2443482A2 · 2012 [cited by applicant]
EP 1355965B1 · 2012 [cited by applicant]
EP 1932874B1 · 2013 [cited by applicant]
EP 2461767B1 · 2013 [cited by applicant]
EP 2455104B1 · 2013 [cited by applicant]
EP 2624871A2 · 2013 [cited by applicant]
JP H09507784A · 1997 [cited by applicant]
JP 2000512677A · 2000 [cited by applicant]
JP 2000351862A · 2000 [cited by applicant]
JP 2001131271A · 2001 [cited by applicant]
JP 2001518528A · 2001 [cited by applicant]
JP 2003512513A · 2003 [cited by applicant]
JP 2003527890A · 2003 [cited by applicant]
JP 2005520703A · 2005 [cited by applicant]
JP 2006508720A · 2006 [cited by applicant]
JP 2008511870A · 2006 [cited by applicant]
JP 2013533518A · 2013 [cited by applicant]
WO WO9300391A1 · 1993 [cited by applicant]
WO WO9828026A1 · 1998 [cited by applicant]
WO WO9955742A1 · 1999 [cited by applicant]
WO WO0105578A1 · 2001 [cited by applicant]
WO WO0132230A2 · 2001 [cited by applicant]
WO WO0144861A1 · 2001 [cited by applicant]
WO WO0157118A2 · 2001 [cited by applicant]
WO WO0192924A1 · 2001 [cited by applicant]
WO WO0216974A2 · 2002 [cited by applicant]
WO WO02096477A2 · 2002 [cited by applicant]
WO WO02097481A1 · 2002 [cited by applicant]
WO WO03041754A1 · 2003 [cited by applicant]
WO WO03057270A1 · 2003 [cited by applicant]
WO WO03075888A2 · 2003 [cited by applicant]
WO WO2004024203A1 · 2004 [cited by applicant]
WO WO2004025332A1 · 2004 [cited by applicant]
WO WO2004056403A2 · 2004 [cited by applicant]
WO WO2004056404A2 · 2004 [cited by applicant]
WO WO2004080297A1 · 2004 [cited by applicant]
WO WO2005014074A1 · 2005 [cited by applicant]
WO WO2005035607A1 · 2005 [cited by applicant]
WO WO2007002671A1 · 2007 [cited by applicant]
WO WO2007146137A2 · 2007 [cited by applicant]
WO WO2008024071A1 · 2008 [cited by applicant]
WO WO2008079809A2 · 2008 [cited by applicant]
WO WO2008094876A1 · 2008 [cited by applicant]
WO WO2008101417A1 · 2008 [cited by applicant]
WO WO2008130604A2 · 2008 [cited by applicant]
WO WO2008156604A1 · 2008 [cited by applicant]
WO WO2009042191A1 · 2009 [cited by applicant]
WO WO2009055082A2 · 2009 [cited by applicant]
WO WO2009094368A1 · 2009 [cited by applicant]
WO WO2010003078A2 · 2010 [cited by applicant]
WO WO2010011492A1 · 2010 [cited by applicant]
WO WO2010018293A1 · 2010 [cited by applicant]
WO WO2010056686A1 · 2010 [cited by applicant]
WO WO2010065686A1 · 2010 [cited by applicant]
WO WO2010065960A2 · 2010 [cited by applicant]
WO WO2010103089A1 · 2010 [cited by applicant]
WO WO2011007454A1 · 2011 [cited by applicant]
WO WO2011056761A1 · 2011 [cited by applicant]
WO WO2011071790A1 · 2011 [cited by applicant]
WO WO2011071791A1 · 2011 [cited by applicant]
WO WO2012035598A1 · 2012 [cited by applicant]
WO WO2012149256A2 · 2012 [cited by applicant]
WO WO2012055884A1 · 2012 [cited by applicant]
WO WO2012074859A1 · 2012 [cited by applicant]
WO WO2012082704A1 · 2012 [cited by applicant]
WO WO2012153072A1 · 2012 [cited by applicant]
WO WO2013055746A1 · 2013 [cited by applicant]
WO WO2013074535A1 · 2013 [cited by applicant]
WO WO2013166358A1 · 2013 [cited by applicant]
WO WO2015031196A1 · 2015 [cited by applicant]
Bearinger et al.; P(Aam-co-EG) interpenetrating polymer networks grafted to oxide surfaces: surface characterization, protein adsorption, and cell detachment studies; Langmuir; 13(19); pp. 5175-5183; Sep. 17, 1997. [cited by applicant]
Bundgaard et al.; N-Sulfonyl imidates as a novel prodrug form for an ester function or a sulfonamide group; J Med Chem; 31(11); pp. 2066-2069; Nov. 1988. [cited by applicant]
Chattopadhyay et al.; Functional polymers bearing reactive azetidinium groups; synthesis and characterization; Macromoleular Chemistry and Physics; 213(5); pp. 500-512; Mar. 2012. [cited by applicant]
Chang et al.; U.S. Appl. No. 61/180,453 entitled “Actinically-crosslinkable siloxane-containing copolymers,” filed May 22, 2009. [cited by applicant]
Dilsiz et al.; Plasma Polymerization of Selected Organic Compounds; Polymer; 37(2); pp. 333-342; Jan. 1996. [cited by applicant]
Hoepfner et al. (Editors); Tetronic; Fiedler Encyclopedia of Excipients for Pharmaceuticals, Cosmetics and Related Areas 5th ed.; Der Pharmazeutische vol. 9; vol. 2 (L-Z); p. 1586; 2002 (the year of publication is suffi… [cited by applicant]
Hoepfner et al. (Editors); Pluronics; Fiedler Encyclopedia of Excipients for Pharmaceuticals, Cosmetics and Related Areas 5th ed.; Der Pharmazeutische vol. 9; vol. 2 (L-Z); pp. 1224-1227; 2002 (the year of publication i… [cited by applicant]
Ghormely; The advent contact lens-clinical viewpoints; 3 pages; retrieved from http://www.sciencedirect.com/science/article/pii/0892896789900321/pdf?md5=5ff798a43537ff29c508eb02d36dd&pid=1-2.0-0892896789900321-main.pdf … [cited by applicant]
Greene et al.; Protective Groups in Organic Synthesis; 2nd Ed.; John Wiley & Sons; New York, NY; pp. 178-210; Oct. 1991. [cited by applicant]
Guruvenket et al.; Plasma surface modification of polystyrene and polyethylene; Applied Surface Science; 236(1-4); pp. 278-284; Sep. 15, 2004. [cited by applicant]
Hall et al.; Activated gas plasma surface treatment of polymers for treatment of polymers for adhesive bonding; Journal of Applied Polymer Science; 13(10); pp. 2085-2096; Oct. 1969. [cited by applicant]
Herman; Fluorescence microscopy Second ed.; Bios Scientific Publishers;Chapter Two: Fluorescence microscopy; pp. 15-19: 1998 the year of publication is sufficiently earlier than the effective U.S. filing date and any fo… [cited by applicant]
Hermanson; Chapter 3: The Reactions of Bioconjugation; in Bioconjugate Techniques; 3rd Ed.; Academic Press, San Diego, CA; pp. 229-258; Sep. 2013. [cited by applicant]
Justynska et al.; U.S. Appl. No. 61/180,449 entitled “Actinically-crosslinkable siloxane-containing copolymers,” filed May 22, 2009. [cited by applicant]
Kayaman et al.; Phase transition of polyacrylamide gels in PEG solutions; Polymer Gels and Networks, 5(2); pp. 167-184; Apr. 1997. [cited by applicant]
Keana et al.; New Reagents for Photoaffinity Labeling: Synthesis and Photolysis of Functionalized Perfluorophenyl Azides; J. Org. Chem.; 55(11); pp. 3640-3647; May 1990. [cited by applicant]
Pantar; The polymerization of acrylamide in the presence of poly (ethylene glycol) II; European Polymer Journal; 22(11); pp. 939-942; Jan. 1986. [cited by applicant]
Park et al.; Surface modifications of poly(ethylene terephthalate) angioplasty balloons with a hydrophilic poly(acrylamide-co-ethylene glycol) interpenetrating polymer network coating; J. Biomed. Mater. Res.; 53(5); pp.… [cited by applicant]
Petracek et al.; Hydroxymethylketones as pro-drugs; Annals NY Acad Sci; 507; pp. 353-354; Dec. 1987. [cited by applicant]
Pissis; Hydration studies in polymer hydrogels; Journal of Polymer Science Part B: Polymer Physics; 51(3); pp. 159-175; Feb. 2013. [cited by applicant]
Polymer Properties Database; Polyacrylamides; 2 pages; retrieved from the internet (https://polymerdatabase.com/polymer%20classes/Polyacrylamide%20type.html); on Jul. 9, 2021. [cited by applicant]
Read et al.; Dynamic contact angle analysis of silicone hydrogel contact lenses; Journal of Biomaterials Applications; 26(1); pp. 85-99; Jul. 2011. [cited by applicant]
Szczotka-Flynn; Introducing the latest silicone hydrogel lens; Contact Lens Spectrum; 20(8); 2 pages; retrieved from the internet (https://www.clspectrum.com/issues/2005/august-2005/contact-lens-materials); Aug. 1, 2005. [cited by applicant]
The Merck Index, An Encyclopedia of chemicals, drugs, and biologicals; Ed. Susan Budavari; 12th Edition; “7519 Phosphorycholine”; p. 1267; 1996 (the year of publication is sufficiently earlier than the effective U.S. fi… [cited by applicant]
Wilson; Resolution and optical sectioning in the confocal microscope; Journal of Microscopy; 244(2); pp. 113-121; Nov. 2011. [cited by applicant]
Vladkova; Surface engineered polymeric biomaterials with improved biocontact properties; International Journal of Polymer Science; Article ID 296094 doi: 10.1155/2010/296094; 22 pages; 2010 (the year of publication is s… [cited by applicant]
Yamada et al.; Selective modification of aspartic acid-101 in lysozyme by carbodiimide reaction; Biochemistry; 20(17); pp. 4836-4842; Aug. 1981. [cited by applicant]
Yasuda; Glow discharge polymerization; Journal of Polymer Science: Macromolecular Reviews; 16(1); pp. 199-293; 1981 (the year of publication is sufficiently earlier than the effective U.S. filing date and any foreign pr… [cited by applicant]
Yongruida; Polyacrylamide (PAM) (Product Description); 5 pages; retrieved from the internet (https://www.yrdcarbon.com/products/chemical/polyacrylamide.html) on Jul. 29, 2021. [cited by applicant]
Mabry et a.; U.S. Appl. No. 17/413,665 entitled “Systems and methods of treating a hydrogel-coated medical device,” filed Jun. 14, 2021. [cited by applicant]