IP Library › Granted Patent US 11,918,831
Granted Patent B2
US 11,918,831 · App. 17/464,665 · Granted Mar 5, 2024

Hybrid bragg/flash proton therapy apparatus and method of use thereof

Inventors: Susan L. Michaud (Brewster, MA); Ran Tu (Malden, MA); Daniel J. Raymond (Windham, NH)
A61N5/1077A61B6/03A61N5/1044A61N5/1067A61N5/1082G21K1/087G21K1/093G21K5/04A61N5/107A61N2005/1074A61N2005/1087A61N2005/1097H01J35/147
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Quick Facts
Patent No.
US 11,918,831
App. No.
17/464,665
Granted
Mar 5, 2024
Kind
B2
Abstract

The invention comprises a method and apparatus for treating a tumor of a patient with positively charged particles, comprising the steps of transporting the positively charged particles along a beam transport path passing sequentially from an accelerator, through a beam transport line, through a nozzle, and toward a position of the patient, the step of transporting further comprising the steps of: (1) terminating a first Bragg peak, of a first set of the positively charged particles, in a position of the tumor and (2) flash treating the tumor with a second Bragg peak, of a second set of the positively charged particles, the second Bragg peak terminating post-patient relative to the nozzle. Optionally the second set of particles are delivered at a rate exceeding one MHz. Optionally, particles in common are used to both treat the tumor and image the tumor.

Claims (48)

1. A method for treating a tumor of a patient with positively charged particles, comprising the step of:

transporting the positively charged particles along a beam transport path passing sequentially from an accelerator, through a beam transport line, through a nozzle, and toward a position of the patient, said step of transporting further comprising the steps of:

terminating a first Bragg peak, of a first set of the positively charged particles, in a position of the tumor; and

flash treating the tumor with a second Bragg peak, of a second set of the positively charged particles, the second Bragg peak terminating post-patient relative to said nozzle.

2. The method of claim 1 , said step of treating further comprising the step of:

delivering the second set of the positively charged particles terminating post-patient at a rate exceeding one MHz.

3. The method of claim 2 , further comprising the step of:

imaging the tumor with the second set of the positively charged particles, said step of imaging comprising a step of detecting a position of the second set of the positively charged particles after passing through the position of the patient during said step of flash treating.

4. The method of claim 1 , further comprising the step of:

cycling at least three times between said step of terminating and treating during a single treatment session of the tumor.

5. The method of claim 1 , further comprising the step of:

detecting common particles, of the positively charged particles, in said step of treating and a step of imaging the tumor.

6. The method of claim 5 , said step of detecting further comprising the step of:

determining a post-patient beam position with an organic film charged particle detector comprising germanium.

7. The method of claim 1 , further comprising a step of:

detecting a position of the second set of the positively charged particles, said step of detecting further comprising the steps of:

detecting a missed treatment voxel of the tumor; and

treating said missed treatment voxel in accordance to a prescribed treatment during a single treatment session of the tumor.

8. The method of claim 1 , further comprising the steps of:

providing a set of fiducial indicators, said set of fiducial indicators comprising:

a set of fiducial markers; and

a set of fiducial detectors;

placing said fiducial indicators on each of a set of objects in a treatment room, said set of objects comprising said nozzle;

detecting photons from said set of fiducial markers with said set of fiducial detectors;

determining a relative position of said nozzle and the tumor using output from said set of fiducial detectors; and

targeting the tumor, with the positively charged particles, with the relative position of said nozzle system and the tumor.

9. The method of claim 1 , further comprising the step of:

guiding the positively charged particles with a main winding coil wound around at least two magnet cores and a correction winding coil wound around said at least two magnet cores, said correction winding coil carrying less than ten percent of the a main current passing along said main winding coil.

10. The method of claim 1 , said step of transporting further comprising the step of:

guiding an electron beam through said beam transport path toward the tumor during a treatment session including said steps of terminating and treating.

11. An apparatus for treating a tumor of a patient with positively charged particles, comprising:

a cancer therapy system comprising a beam transport path, configured to transport the positively charged particles, said beam transport path sequentially comprising an accelerator, a beam transport line, a nozzle, and a patient position,

said cancer therapy system configured to treat the tumor, during a single treatment session, with:

a first Bragg peak of a first set of the positively charged particles in a position of the tumor; and

a second Bragg peak of a second set of the positively charged particles in a post-patient position relative to said nozzle; and

a beam rate controller controlling the second set of positively charged particles at a delivery rate exceeding one MHz.

12. The apparatus of claim 11 , further comprising:

a detector positioned in the beam transport path after the patient position relative to said nozzle, said detector further comprising:

a first layer comprising a first scintillation material, said first scintillation material, responsive to passage of the positively charged particles, emitting first secondary photons over a first wavelength range; and

a second layer comprising a second scintillation material, said second scintillation material, responsive to passage of the positively charged particles, emitting second secondary photons over a second wavelength range, the first scintillation material differing in material type from the second scintillation material.

13. The apparatus of claim 11 , further comprising:

a detector positioned in the beam transport path after the patient position relative to said nozzle, said detector comprising an organic semi-conducting film.

14. The apparatus of claim 13 , said organic semi-conducting film comprising germanium and a pentacene.

15. The apparatus of claim 11 , said nozzle further comprising:

a double dipole scanning system, comprising:

a beam path chamber comprising an entrance side and an exit side, the entrance side comprising a top of a truncated pyramid shape, the exit side comprising a bottom of the truncated pyramid shape;

a first dipole magnet, said first dipole magnet comprising a first coil and a third coil on first opposite sides of said beam path chamber; and

a second dipole magnet, said second dipole magnet comprising a second coil and a fourth coil on second opposite sides of said beam path chamber.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 15, 2023
From: MICHAUD, SUSAN L; TU, RAN; RAYMOND, DANIEL J
To: PROTOM INTERNATIONAL HOLDING CORPORATION
Reel/Frame 062379/0044 →
Continuity (21)
Continuation In Part 17399415 · Aug 11, 2021
Continuation In Part 17383836 · Jul 23, 2021
Continuation In Part 17382044 · Jul 21, 2021
Continuation In Part 16903736 · Jun 17, 2020
Continuation In Part 16533761 · Aug 6, 2019
Continuation In Part 15901788 · Feb 21, 2018
Continuation In Part 15892240 · Feb 8, 2018
Continuation In Part 15868897 · Jan 11, 2018
Continuation In Part 15838072 · Dec 11, 2017
Continuation In Part 15823148 · Nov 27, 2017
Continuation In Part 15467840 · Mar 23, 2017
Continuation In Part 15402739 · Jan 10, 2017
Continuation In Part 15348625 · Nov 10, 2016
Continuation In Part 15167617 · May 27, 2016
Continuation 15152479 · May 11, 2016
Continuation In Part 14216788 · Mar 17, 2014
Continuation In Part 13087096 · Apr 14, 2011
Provisional Application 63174131 · Apr 13, 2021
Provisional Application 63174157 · Apr 13, 2021
Provisional Application 61324776 · Apr 16, 2010
Related Publication 20210393987A1 · Dec 23, 2021
Cited By (2)
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