IP Library › Granted Patent US 12,478,631
Granted Patent B2
US 12,478,631 · App. 17/570,194 · Granted Nov 25, 2025

Stabilized modified release vitamin D formulation and method of administering same

Inventors: Jay A. White (Newmarket, CA); Samir P. Tabash (Whitby, CA); Sammy A. Agudoawu (Mississauga, CA); Joel Z. Melnick (Evanston, IL)
Assignee: EIRGEN PHARMA LTD.
A61K31/593A61K9/2054A61K9/2866A61K9/4866A61K31/592A61K47/38A61K47/44
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Quick Facts
Patent No.
US 12,478,631
App. No.
17/570,194
Granted
Nov 25, 2025
Kind
B2
Abstract

A stabilized formulation for controlled release of a vitamin D compound is disclosed. The formulation can comprise one or both of 25-hydroxyvitamin D 2 and 25-hydroxyvitamin D 3 and a stabilizing compound. The stabilized formulations exhibit a stable dissolution profile following exposure to storage conditions and demonstrate improved pharmacokinetic parameters compared to unstabilized formulations.

Claims (23)

1 . A pharmaceutical composition comprising a storage-stabilized formulation for sustained release of a vitamin D compound, wherein the storage-stabilized formulation comprises a mixture of: a vitamin D compound; and a stabilizing agent selected from one or more of a povidone polymer and a fumed silica, in an amount of about 5 wt % to about 30 wt % of the storage-stabilized formulation, wherein the stabilizing agent maintains a difference of less than 30% between the amount of vitamin D compound released at any given time point after four hours during in vitro dissolution after two months exposure to storage conditions of 25° C. and 60% relative humidity and the amount released at the same dissolution time point during in vitro dissolution conducted prior to exposing the formulation to the storage conditions,

wherein the storage-stabilized formulation comprises a lipophilic matrix comprising the vitamin D compound.

2 . The pharmaceutical composition of claim 1 , wherein the lipophilic matrix comprises a wax.

3 . The pharmaceutical composition of claim 2 , wherein the lipophilic matrix comprises an emulsifier.

4 . The pharmaceutical composition of claim 3 , wherein the lipophilic matrix comprises a wax, an emulsifier, and an absorption enhancer.

5 . The pharmaceutical composition of claim 4 , wherein the wax comprises paraffin.

6 . The pharmaceutical composition of claim 2 , wherein the wax comprises paraffin.

7 . The pharmaceutical composition of claim 1 , wherein the storage-stabilized formulation is an oral formulation for sustained release of the vitamin D compound in the gastrointestinal tract of a subject which ingests the formulation.

8 . The pharmaceutical composition of claim 1 , wherein the storage-stabilized formulation comprises a matrix that releasably binds and controllably releases the vitamin D compound.

9 . The pharmaceutical composition according to claim 1 , wherein the stabilizing agent is a povidone polymer.

10 . The pharmaceutical composition according to claim 1 , wherein the stabilizing agent is a fumed silica.

11 . The pharmaceutical composition according to claim 1 , wherein the vitamin D compound is one or more of vitamin D 3 (cholecalciferol), vitamin D 2 (ergocalciferol), 25-hydroxyvitamin D 3 , 25-hydroxyvitamin D 2 , 25-hydroxyvitamin D4, 25-hydroxyvitamin D 5 , 25-hydroxyvitamin D 7 , 1α,25-dihydroxyvitamin D3, 1α,25-dihydroxyvitamin D 2 , 1α,25-dihydroxyvitamin D 4 , 1,25-dihydroxy-19-nor-vitamin D 2 , and 1α-hydroxyvitamin D 3 .

12 . The pharmaceutical composition according to claim 11 , wherein the vitamin D compound comprises one or both of 25-hydroxyvitamin D 2 and 25-hydroxyvitamin D 3 .

13 . The pharmaceutical composition according to claim 1 , wherein the vitamin D compound comprises 25-hydroxyvitamin D 3 .

14 . The pharmaceutical composition of claim 1 , wherein the storage-stabilized formulation is in the form of a capsule, tablet, sachet, dragee, or suppository.

15 . The pharmaceutical composition of claim 14 , wherein the storage-stabilized formulation is in the form of a capsule.

16 . The pharmaceutical composition of claim 1 , wherein the formulation releases an amount of the vitamin D compound during in vitro dissolution after exposure to storage conditions for one month at 40° C. and 75% relative humidity that varies at any given dissolution time point after four hours compared to the amount released at the same dissolution time point during in vitro dissolution conducted prior to exposing the formulation to the storage conditions, by 30% or less.

17 . A method of vitamin D supplementation comprising administering to a subject the pharmaceutical composition of claim 1 .

18 . A pharmaceutical composition comprising a storage-stabilized formulation for sustained release of a vitamin D compound, wherein the storage-stabilized formulation comprises a mixture of: a vitamin D compound; and a stabilizing agent selected from one or more of a povidone polymer and a fumed silica, in an amount of about 5 wt % to about 30 wt % of the storage-stabilized formulation, wherein the stabilizing agent maintains a difference of less than 30% between the amount of vitamin D compound released at any given time point after four hours during in vitro dissolution after two months exposure to storage conditions of 25° C. and 60% relative humidity and the amount released at the same dissolution time point during in vitro dissolution conducted prior to exposing the formulation to the storage conditions,

wherein the storage-stabilized formulation comprises an oily vehicle and a lipophilic matrix comprising the vitamin D compound.

19 . The pharmaceutical composition of claim 18 , wherein the oily vehicle is selected from fish oil, vegetable oil, and mineral oil.

20 . The pharmaceutical composition according to claim 18 , wherein the stabilizing agent is a povidone polymer.

21 . The pharmaceutical composition according to claim 18 , wherein the stabilizing agent is a fumed silica.

Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 7, 2024
From: WHITE, JAY A.; TABASH, SAMIR P.; AGUDOAWU, SAMMY A.; MELNICK, JOEL Z.
To: OPKO IP HOLDINGS II., INC.
Reel/Frame 068208/0627 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 7, 2024
From: OPKO IP HOLDINGS II., INC.
To: OPKO IRELAND GLOBAL HOLDINGS., LTD.
Reel/Frame 068208/0682 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 7, 2024
From: OPKO IRELAND GLOBAL HOLDINGS LTD.
To: EIRGEN PHARMA LTD.
Reel/Frame 068208/0739 →
Continuity (5)
Continuation 16448838 · Jun 21, 2019
Division 15720948 · Sep 29, 2017
Continuation 14213285 · Mar 14, 2014
Provisional Application 61801896 · Mar 15, 2013
Related Publication 20220125806A1 · Apr 28, 2022
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