IP Library › Granted Patent US 12,648,572
Granted Patent B2
US 12,648,572 · App. 17/919,940 · Granted Jun 9, 2026

Proteolytically stable U1-agatoxin-Ta1b variant polypeptides for pest control

Inventors: Kyle Schneider (Kalamazoo, MI); Alexandra Haase (Kalamazoo, MI); Breck Davis (Kalamazoo, MI); Ryan Garrett (Kalamazoo, MI)
Assignee: Vestaron Corporation
A01N63/50A01N25/08C12N1/16C12N15/63C12R2001/87
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Quick Facts
Patent No.
US 12,648,572
App. No.
17/919,940
Granted
Jun 9, 2026
Kind
B2
Abstract

New insecticidal proteins, nucleotides, peptides, and their expression in plants. Methods of producing new nucleotides and new peptides, new processes, new production techniques, new formulations, and new organisms. The present disclosure is also related to and describes novel peptides called TVPs, which are non-natural peptide variations based upon the U1-agatoxin-Ta1b toxin derived from the Hobo spider. Here, we describe: genes encoding TVPs; formulations and combinations comprising TVP genes and/or peptides; and methods using the same that are useful for the control of pests.

Claims (10)

1 . A pesticidal U1-agatoxin-Ta1b variant polypeptide (TVP) comprising the amino acid sequence set forth in any one of SEQ ID NO: 2, 49, or 51; or an agriculturally acceptable salt thereof.

2 . A pesticidal U1-agatoxin-Ta1b variant polypeptide (TVP) consisting of the amino acid sequence set forth in any one of SEQ ID NO: 2, 49, or 51; or an agriculturally acceptable salt thereof.

3 . A pesticidal U1-agatoxin-Ta1b variant polypeptide (TVP) comprising the amino acid sequence set forth in SEQ ID NO: 51, or an agriculturally acceptable salt thereof.

4 . A pesticidal U1-agatoxin-Ta1b variant polypeptide (TVP) consisting of the amino acid sequence set forth in SEQ ID NO: 51, or an agriculturally acceptable salt thereof.

5 . A pesticidal U1-agatoxin-Ta1b variant polypeptide (TVP) comprising the amino acid sequence set forth in SEQ ID NO: 2, or an agriculturally acceptable salt thereof.

6 . A pesticidal U1-agatoxin-Ta1b variant polypeptide (TVP) consisting of the amino acid sequence set forth in SEQ ID NO: 2, or an agriculturally acceptable salt thereof.

7 . A pesticidal U1-agatoxin-Ta1b variant polypeptide (TVP) comprising the amino acid sequence set forth in SEQ ID NO: 49, or an agriculturally acceptable salt thereof.

8 . A pesticidal U1-agatoxin-Ta1b variant polypeptide (TVP) consisting of the amino acid sequence set forth in SEQ ID NO: 49, or an agriculturally acceptable salt thereof.

9 . A composition comprising a pesticidal U1-agatoxin-Ta1b variant polypeptide (TVP) and at least one excipient; wherein the TVP comprises the amino acid sequence set forth in any one of SEQ ID NO: 2, 49, or 51, or an agriculturally acceptable salt thereof.

10 . A kit comprising: (1) a pesticidal U1-agatoxin-Ta1b variant polypeptide (TVP) comprising the amino acid sequence set forth in any one of SEQ ID NO: 2, 49, or 51, or an agriculturally acceptable salt thereof; and (2) at least one excipient.

Assignments (5)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 21, 2026
From: VESTARON CORPORATION
To: SUTERRA LLC
Reel/Frame 074729/0824 →
RELEASE OF SECURITY INTEREST Recorded May 5, 2026
From: NOVO HOLDINGS A/S
To: VESTARON CORPORATION
Reel/Frame 074568/0448 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 19, 2025
From: SCHNEIDER, KYLE; HAASE, ALEXANDRA; DAVIS, BRECK; GARRETT, RYAN
To: VESTARON CORPORATION
Reel/Frame 071766/0741 →
SECURITY INTEREST Recorded Apr 1, 2025
From: VESTARON CORPORATION
To: NOVO HOLDINGS A/S
Reel/Frame 070690/0789 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 23, 2024
From: SCHNEIDER, KYLE; HAASE, ALEXANDRA M.; DAVIS, BRECK
To: VESTARON CORPORATION
Reel/Frame 067509/0839 →
Continuity (2)
Provisional Application 63012755 · Apr 20, 2020
Related Publication 20230337684A1 · Oct 26, 2023
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