Granted Patent
B2
US 12,201,648 · App. 18/152,240 · Granted Jan 21, 2025
Methods of treating chronic wounds using electrospun fibers
Inventors:
Jason Chakroff (Columbus, OH); Ronald Lloyd Bracken (Monroe, GA); Jed Johnson (London, OH)
Assignee:
NFS IP Holdings, LLC
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Abstract
A method of treating a chronic wound may comprise applying to the wound a first scaffold comprising an electrospun polymer fiber. The electrospun fiber may comprise a polymer selected from the group consisting of polyglycolic acid, poly(lactide-co-caprolactone), polylactic acid, polycaprolactone, copolymers thereof, and combinations thereof. The first scaffold may have a thickness from about 50 μm to about 1 mm, a length from about 1 cm to about 20 cm, and a width from about 1 cm to about 15 cm. The method may further comprise keeping the first scaffold on the chronic wound for a time period of about 3 days to about 21 days. After the time period passes, the chronic wound may have a decreased planimetric area.
Claims (13)
1. A method of reducing an initial pH of a wound, the method comprising:
applying a scaffold to the wound, the scaffold comprising fiber fragments, the fiber fragments comprising at least a first electrospun polymer and a second electrospun polymer, wherein the first electrospun polymer and the second electrospun polymer comprise a polymer selected from the group consisting of polyglycolic acid, poly(lactide-co-caprolactone), polydioxanone, and poly(lactide-co-glycolide); and
allowing at least a portion of the scaffold to degrade over a time period of about 3 days to about 21 days, thereby producing an acidic byproduct having a pH lower than the initial pH of the wound, wherein the acidic byproduct reduces the initial pH of the wound to a target pH from about 4.0 to about 6.0.
2. The method of claim 1 , wherein the initial pH of the wound is from about 7.0 to about 9.0.
3. The method of claim 1 , wherein the acidic byproduct comprises an alpha-hydroxy acid.
4. The method of claim 1 , wherein the fiber fragments form an aggregate.
5. The method of claim 4 , wherein the aggregate of the fiber forms a shape selected from the group consisting of a spherical shape, an ellipsoidal shape, a globular shape, and a flattened cylindrical shape.
6. The method of claim 1 , wherein the wound comprises a chronic wound.
7. The method of claim 1 , wherein applying the scaffold to the wound comprises contacting the scaffold to at least a portion of the wound.
8. The method of claim 1 , wherein applying the scaffold to the wound comprises implanting the scaffold within a body to make contact with the wound.
9. The method of claim 1 , wherein applying the scaffold to the wound comprises directly contacting the scaffold to the wound.
10. The method of claim 1 , wherein applying the scaffold to the wound comprises indirectly contacting the scaffold to the wound.
11. The method of claim 1 , wherein the first electrospun polymer and the second electrospun polymer are co-electrospun with each other.
Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jan 10, 2023
From: CHAKROFF, JASON; BRACKEN, RONALD LLOYD; JOHNSON, JED
To: NANOFIBER SOLUTIONS, LLC
Reel/Frame 062324/0615 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jan 10, 2023
From: NANOFIBER SOLUTIONS, LLC
To: NFS IP HOLDINGS, LLC
Reel/Frame 062324/0692 →
Continuity (3)
Provisional Application
62778024
· Dec 11, 2018
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