IP Library › Granted Patent US 12,514,748
Granted Patent B2
US 12,514,748 · App. 18/298,161 · Granted Jan 6, 2026

Apparatus and methods for treatment of obstructive sleep apnea utilizing cryolysis of adipose tissues

Inventors: Donald A. Gonzales (Folsom, LA); Anthony Natale (New Preston, CT)
Assignee: CRYOSA, INC.
A61F7/12A61B18/02A61B2018/00172A61B2018/00291A61B2018/00327A61B2018/00464A61B2018/00642A61B2018/00714A61B2018/00791A61B2018/0212A61B2018/0262A61B2018/0293A61F2007/001A61F2007/0063A61F2007/0096
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Quick Facts
Patent No.
US 12,514,748
App. No.
18/298,161
Granted
Jan 6, 2026
Kind
B2
Abstract

Methods, devices, and systems employ cryolysis of oropharyngeal adipose tissues to selectively remove fat cells from the tissues causing obstructive sleep apnea. In various embodiments, a chilled liquid—e.g., a liquid or air—is applied to the target tissue at a temperature and for a duration sufficient to cause cryolysis.

Claims (18)

1 . A device for treatment of obstructive sleep apnea, comprising:

a shaft;

an engagement member disposed at a distal end of the shaft and having a contact surface shaped to be complementary to an oropharyngeal tissue target and to cool the oropharyngeal tissue target;

a sensor disposed on the engagement member;

a cooling unit;

a lumen disposed in the shaft and in communication with the engagement member and the cooling unit to circulate a cooling fluid through the engagement member; and

a processor operatively coupled to the cooling unit and the sensor, the processor being configured to responsively adjust a temperature of the cooling fluid with the cooling unit to achieve and maintain a desired temperature of the engagement member sufficient to cause cryolysis of adipose tissue within the oropharyngeal tissue target.

2 . The device of claim 1 , further comprising a coupler adapted to detachably connect the lumen to the cooling unit to receive the cooling fluid into the lumen and return the cooling fluid from the lumen to the cooling unit.

3 . The device of claim 2 , wherein the shaft includes at least one releasably engageable port communicating with the lumen, the at least one releasably engageable port being configured to detachably connect to the cooling unit via the coupler.

4 . The device of claim 1 , wherein the engagement member comprises a flexible and conformal material.

5 . The device of claim 1 , wherein the engagement member further comprises a hinge.

6 . The device of claim 1 , wherein the engagement member comprises a substantially flat plate.

7 . The device of claim 1 , wherein the engagement member comprises a “C”-shaped member configured to be complementary to a base of a tongue.

8 . The device of claim 1 , wherein the engagement member is comprises a “V”-shaped member configured to engage a soft palate or a uvula.

9 . The device of claim 1 , wherein the cooling unit is configured to provide suction to the engagement member to enhance mechanical contact thereof with the oropharyngeal tissue target.

10 . The device of claim 1 , wherein the cooling fluid comprises a liquid.

11 . The device of claim 10 , wherein the liquid comprises a refrigerant.

12 . The device of claim 10 , wherein the liquid comprises a water and glycerine solution.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 10, 2023
From: GONZALES, DONALD A.; NATALE, ANTHONY
To: CRYOSA, LLC
Reel/Frame 063277/0786 →
CHANGE OF NAME Recorded Apr 10, 2023
From: CRYOSA, LLC
To: CRYOSA, INC.
Reel/Frame 063277/0839 →
Continuity (8)
Continuation 16399264 · Apr 30, 2019
Continuation 15949897 · Apr 10, 2018
Continuation 15238652 · Aug 16, 2016
Continuation 14736447 · Jun 11, 2015
Continuation 13359000 · Jan 26, 2012
Provisional Application 61441207 · Feb 9, 2011
Provisional Application 61436712 · Jan 27, 2011
Related Publication 20230240887A1 · Aug 3, 2023
References Cited (391)
US 3712306A · Bryne · 1973 [cited by applicant]
US 3889680A · Armao · 1975 [cited by applicant]
US 5245023A · Peoples et al. · 1993 [cited by applicant]
US 5250430A · Peoples et al. · 1993 [cited by applicant]
US 5534432A · Peoples et al. · 1996 [cited by applicant]
US 5663063A · Peoples et al. · 1997 [cited by applicant]
US 5743904A · Edwards · 1998 [cited by applicant]
US 5800379A · Edwards et al. · 1998 [cited by applicant]
US 6017337A · Pira · 2000 [cited by applicant]
US 6032675A · Rubinsky · 2000 [cited by applicant]
US 6041787A · Rubinsky · 2000 [cited by applicant]
US 6045549A · Smethers et al. · 2000 [cited by applicant]
US 6126657A · Edward et al. · 2000 [cited by applicant]
US 6245537B1 · Williams et al. · 2001 [cited by applicant]
US 6316262B1 · Huisman et al. · 2001 [cited by applicant]
US 6378525B1 · Beyar et al. · 2002 [cited by applicant]
US 6408851B1 · Karell · 2002 [cited by applicant]
US 6514515B1 · Williams et al. · 2003 [cited by applicant]
US 6548569B1 · Williams et al. · 2003 [cited by applicant]
US 6555123B2 · Williams et al. · 2003 [cited by applicant]
US 6585994B2 · Williams et al. · 2003 [cited by applicant]
US 6592892B1 · Williams et al. · 2003 [cited by applicant]
US 6593116B1 · Huisman et al. · 2003 [cited by applicant]
US 6607517B1 · Dae · 2003 [cited by examiner]
US 6610764B1 · Martin et al. · 2003 [cited by applicant]
US 6623749B2 · Williams et al. · 2003 [cited by applicant]
US 6689589B2 · Huisman et al. · 2004 [cited by applicant]
US 6746447B2 · Davison et al. · 2004 [cited by applicant]
US 6746685B2 · Williams et al. · 2004 [cited by applicant]
US 6770071B2 · Woloszko et al. · 2004 [cited by applicant]
US 6828357B1 · Martin et al. · 2004 [cited by applicant]
US 6838493B2 · Williams et al. · 2005 [cited by applicant]
US 6867247B2 · Williams et al. · 2005 [cited by applicant]
US 6867248B1 · Martin et al. · 2005 [cited by applicant]
US 6878758B2 · Martin et al. · 2005 [cited by applicant]
US D568258S · Adam · 2008 [cited by applicant]
US 7367341B2 · Anderson et al. · 2008 [cited by applicant]
US 7458932B2 · Sun · 2008 [cited by applicant]
US 7507235B2 · Keogh et al. · 2009 [cited by applicant]
US 7575870B1 · Lalvani et al. · 2009 [cited by applicant]
US 7713266B2 · Elkins et al. · 2010 [cited by applicant]
US 7842029B2 · Anderson et al. · 2010 [cited by applicant]
US 7850683B2 · Elkins et al. · 2010 [cited by applicant]
US 7854754B2 · Ting et al. · 2010 [cited by applicant]
US 7862558B2 · Elkins et al. · 2011 [cited by applicant]
US 7998137B2 · Elkins et al. · 2011 [cited by applicant]
US 8192474B2 · Levinson et al. · 2012 [cited by applicant]
US 8275442B2 · Allison · 2012 [cited by applicant]
US 8285390B2 · Levinson et al. · 2012 [cited by applicant]
US 8287579B2 · Nimitz · 2012 [cited by applicant]
US 8298216B2 · Burger et al. · 2012 [cited by applicant]
US 8337539B2 · Ting et al. · 2012 [cited by applicant]
US 8409185B2 · Burger et al. · 2013 [cited by applicant]
US 8523927B2 · Levinson et al. · 2013 [cited by applicant]
US 8603073B2 · Allison · 2013 [cited by applicant]
US 8676338B2 · Levinson et al. · 2014 [cited by applicant]
US 8702774B2 · Baker et al. · 2014 [cited by applicant]
US 8715275B2 · Burger et al. · 2014 [cited by applicant]
US 8768468B2 · Garcia et al. · 2014 [cited by applicant]
US 8834547B2 · Anderson et al. · 2014 [cited by applicant]
US 8840608B2 · Anderson et al. · 2014 [cited by applicant]
US 9033966B2 · McKay · 2015 [cited by applicant]
US 9039688B2 · Palmer et al. · 2015 [cited by applicant]
US 9072498B2 · Elkins et al. · 2015 [cited by applicant]
US 9078634B2 · Gonzales et al. · 2015 [cited by applicant]
US 9101346B2 · Burger et al. · 2015 [cited by applicant]
US 9113855B2 · Burger et al. · 2015 [cited by applicant]
US 9254162B2 · Burger et al. · 2016 [cited by applicant]
US 9295512B2 · Allison et al. · 2016 [cited by applicant]
US 9308120B2 · Anderson et al. · 2016 [cited by applicant]
US 9314290B2 · Fourkas et al. · 2016 [cited by applicant]
US 9345526B2 · Elkins et al. · 2016 [cited by applicant]
US 9402676B2 · Babkin et al. · 2016 [cited by applicant]
US 9408745B2 · Levinson et al. · 2016 [cited by applicant]
US 9439805B2 · Gonzales et al. · 2016 [cited by applicant]
US 9545523B2 · Nanda · 2017 [cited by applicant]
US 9610112B2 · Karnik et al. · 2017 [cited by applicant]
US 9844461B2 · Levinson et al. · 2017 [cited by applicant]
US 9861421B2 · O'Neil et al. · 2018 [cited by applicant]
US 9907693B2 · Burger et al. · 2018 [cited by applicant]
US 9980765B2 · Avram et al. · 2018 [cited by applicant]
US 10085881B2 · Karnik et al. · 2018 [cited by applicant]
US 10092346B2 · Levinson et al. · 2018 [cited by applicant]
US 10111774B2 · Gonzales et al. · 2018 [cited by applicant]
US 10201380B2 · DeBenedictis et al. · 2019 [cited by applicant]
US 10213244B2 · Fourkas et al. · 2019 [cited by applicant]
US 10363080B2 · Elkins et al. · 2019 [cited by applicant]
US 10441459B2 · Aronhalt et al. · 2019 [cited by applicant]
US 10470813B2 · Allison et al. · 2019 [cited by applicant]
US 10568759B2 · Yee et al. · 2020 [cited by applicant]
US 10575890B2 · DeBenedictis et al. · 2020 [cited by applicant]
US 10582960B2 · Avram et al. · 2020 [cited by applicant]
US 10596030B2 · Karnik et al. · 2020 [cited by applicant]
US 10646666B2 · Cohn et al. · 2020 [cited by applicant]
US 10675178B2 · Levinson et al. · 2020 [cited by applicant]
US 10806500B2 · DeBenedictis et al. · 2020 [cited by applicant]
US 10864112B2 · Burger et al. · 2020 [cited by applicant]
US 10869779B2 · Burger et al. · 2020 [cited by applicant]
US 10888366B2 · Allison et al. · 2021 [cited by applicant]
US 10912599B2 · O'Neil et al. · 2021 [cited by applicant]
US 10939947B2 · Burger et al. · 2021 [cited by applicant]
US 11076879B2 · Yee et al. · 2021 [cited by applicant]
US 11116566B2 · Dinger et al. · 2021 [cited by applicant]
US 11154418B2 · Frangineas · 2021 [cited by applicant]
US 11253393B2 · Karnik et al. · 2022 [cited by applicant]
US 11272972B2 · Allison et al. · 2022 [cited by applicant]
US 11284934B2 · Lazarus et al. · 2022 [cited by applicant]
US 11324673B2 · Velis et al. · 2022 [cited by applicant]
US 11419757B2 · Gonzales · 2022 [cited by examiner]
US 11437150B2 · Rondoni et al. · 2022 [cited by applicant]
US 11439532B2 · Vellis · 2022 [cited by applicant]
US 11446175B2 · Jimenez Lozano et al. · 2022 [cited by applicant]
US 11446178B2 · Velis · 2022 [cited by applicant]
US D967164S · Mairs et al. · 2022 [cited by applicant]
US 11457971B2 · Wolf et al. · 2022 [cited by applicant]
US 11478643B2 · Verzal et al. · 2022 [cited by applicant]
US 11504322B2 · Garibyan et al. · 2022 [cited by applicant]
US 11510722B2 · Wolf et al. · 2022 [cited by applicant]
US 11511117B2 · Ni et al. · 2022 [cited by applicant]
US D971935S · Mairs et al. · 2022 [cited by applicant]
US D971936S · Mairs et al. · 2022 [cited by applicant]
US D971937S · Mairs et al. · 2022 [cited by applicant]
US D971950S · Mairs et al. · 2022 [cited by applicant]
US 11517365B1 · Mazor et al. · 2022 [cited by applicant]
US 11534335B2 · Gonzales et al. · 2022 [cited by applicant]
US 11583438B1 · Levinson et al. · 2023 [cited by applicant]
US 20020026226A1 · Ein · 2002 [cited by applicant]
US 20020062831A1 · Beyar et al. · 2002 [cited by applicant]
US 20020164729A1 · Skraly et al. · 2002 [cited by applicant]
US 20030060685A1 · Houser · 2003 [cited by applicant]
US 20030069572A1 · Wellman · 2003 [cited by applicant]
US 20030220374A1 · Needleman · 2003 [cited by applicant]
US 20030220674A1 · Anderson et al. · 2003 [cited by applicant]
US 20040234576A1 · Martin et al. · 2004 [cited by applicant]
US 20040249416A1 · Yun et al. · 2004 [cited by applicant]
US 20050043682A1 · Kucklick · 2005 [cited by applicant]
US 20050133026A1 · Seleznev et al. · 2005 [cited by applicant]
US 20060235264A1 · Vassallo · 2006 [cited by applicant]
US 20070010861A1 · Anderson et al. · 2007 [cited by applicant]
US 20070129714A1 · Elkins et al. · 2007 [cited by applicant]
US 20070144539A1 · van der Burg et al. · 2007 [cited by applicant]
US 20070154538A1 · Neuberger et al. · 2007 [cited by applicant]
US 20070163603A1 · Sikora · 2007 [cited by applicant]
US 20070198071A1 · Ting et al. · 2007 [cited by applicant]
US 20070255362A1 · Levinson et al. · 2007 [cited by applicant]
US 20070270925A1 · Levinson et al. · 2007 [cited by applicant]
US 20080023012A1 · Dineen et al. · 2008 [cited by applicant]
US 20080058584A1 · Hirotsuka et al. · 2008 [cited by applicant]
US 20080066769A1 · Dineen et al. · 2008 [cited by applicant]
US 20080066864A1 · Ballantine et al. · 2008 [cited by applicant]
US 20080077201A1 · Levinson et al. · 2008 [cited by applicant]
US 20080077202A1 · Levinson et al. · 2008 [cited by applicant]
US 20080077211A1 · Levinson et al. · 2008 [cited by applicant]
US 20080083461A1 · Viken · 2008 [cited by applicant]
US 20080132891A1 · Nobis · 2008 [cited by applicant]
US 20080183164A1 · Elkins et al. · 2008 [cited by applicant]
US 20080188947A1 · Sanders · 2008 [cited by applicant]
US 20080200910A1 · Burger et al. · 2008 [cited by applicant]
US 20080287839A1 · Rosen et al. · 2008 [cited by applicant]
US 20090014012A1 · Sanders · 2009 [cited by applicant]
US 20090018623A1 · Levinson et al. · 2009 [cited by applicant]
US 20090018624A1 · Levinson et al. · 2009 [cited by applicant]
US 20090018625A1 · Levinson et al. · 2009 [cited by applicant]
US 20090018626A1 · Levinson et al. · 2009 [cited by applicant]
US 20090018627A1 · Levinson et al. · 2009 [cited by applicant]
US 20090107001A1 · McCarty · 2009 [cited by applicant]
US 20090118722A1 · Ebbers et al. · 2009 [cited by applicant]
US 20090120446A1 · Vaska et al. · 2009 [cited by applicant]
US 20090123886A1 · Vaska et al. · 2009 [cited by applicant]
US 20090149929A1 · Levinson et al. · 2009 [cited by applicant]
US 20090192504A1 · Askew · 2009 [cited by applicant]
US 20090287060A1 · Pell et al. · 2009 [cited by applicant]
US 20090287210A1 · Kauphusman · 2009 [cited by applicant]
US 20100057065A1 · Krimsky · 2010 [cited by applicant]
US 20100081971A1 · Allison · 2010 [cited by applicant]
US 20100100089A1 · Niethammer · 2010 [cited by applicant]
US 20100152824A1 · Allison · 2010 [cited by applicant]
US 20100280582A1 · Baker · 2010 [cited by applicant]
US 20110066216A1 · Ting et al. · 2011 [cited by applicant]
US 20110155143A1 · Shantha · 2011 [cited by applicant]
US 20110166598A1 · Gonzales et al. · 2011 [cited by applicant]
US 20110224761A1 · Manstein · 2011 [cited by applicant]
US 20110238050A1 · Allison et al. · 2011 [cited by applicant]
US 20110238051A1 · Levinson et al. · 2011 [cited by applicant]
US 20110300079A1 · Martin et al. · 2011 [cited by applicant]
US 20120022518A1 · Levinson et al. · 2012 [cited by applicant]
US 20120085174A1 · Urbano · 2012 [cited by applicant]
US 20120239123A1 · Weber et al. · 2012 [cited by applicant]
US 20120265186A1 · Burger · 2012 [cited by applicant]
US 20130066309A1 · Levinson et al. · 2013 [cited by applicant]
US 20130079684A1 · Rosen et al. · 2013 [cited by applicant]
US 20130116758A1 · Levinson et al. · 2013 [cited by applicant]
US 20130116759A1 · Levinson et al. · 2013 [cited by applicant]
US 20130158440A1 · Allison · 2013 [cited by applicant]
US 20130158636A1 · Ting et al. · 2013 [cited by applicant]
US 20130245731A1 · Allison · 2013 [cited by applicant]
US 20130253384A1 · Anderson et al. · 2013 [cited by applicant]
US 20130253494A1 · Anderson et al. · 2013 [cited by applicant]
US 20130253495A1 · Anderson et al. · 2013 [cited by applicant]
US 20130253496A1 · Anderson et al. · 2013 [cited by applicant]
US 20140005760A1 · Levinson et al. · 2014 [cited by applicant]
US 20140067025A1 · Levinson et al. · 2014 [cited by applicant]
US 20140257443A1 · Baker et al. · 2014 [cited by applicant]
US 20140277219A1 · Nanda · 2014 [cited by applicant]
US 20140277302A1 · Weber et al. · 2014 [cited by applicant]
US 20140316393A1 · Levinson et al. · 2014 [cited by applicant]
US 20150047301A1 · Messersi · 2015 [cited by applicant]
US 20150148791A1 · Birdsall et al. · 2015 [cited by applicant]
US 20150216719A1 · DeBenedictis et al. · 2015 [cited by applicant]
US 20150216720A1 · DeBenedictis et al. · 2015 [cited by applicant]
US 20150216816A1 · O'Neil et al. · 2015 [cited by applicant]
US 20150251120A1 · Jakop · 2015 [cited by applicant]
US 20160022345A1 · Baust et al. · 2016 [cited by applicant]
US 20160051401A1 · Yee et al. · 2016 [cited by applicant]
US 20160183997A1 · Burnett et al. · 2016 [cited by applicant]
US 20160324576A1 · Ebbutt · 2016 [cited by applicant]
US 20160338752A1 · Sperling · 2016 [cited by applicant]
US 20160354234A1 · Dabrowiak · 2016 [cited by applicant]
US 20170079833A1 · Frangineas et al. · 2017 [cited by applicant]
US 20170105869A1 · Frangineas et al. · 2017 [cited by applicant]
US 20170196731A1 · DeBenedictis et al. · 2017 [cited by applicant]
US 20170239079A1 · Root et al. · 2017 [cited by applicant]
US 20170325992A1 · DeBenedictis et al. · 2017 [cited by applicant]
US 20170325993A1 · Lozano et al. · 2017 [cited by applicant]
US 20170326042A1 · Zeng et al. · 2017 [cited by applicant]
US 20170326346A1 · Lozano et al. · 2017 [cited by applicant]
US 20180185081A1 · O'Neil et al. · 2018 [cited by applicant]
US 20180206900A1 · Sperling · 2018 [cited by applicant]
US 20180235805A1 · Burger et al. · 2018 [cited by applicant]
US 20190069949A1 · Vrba et al. · 2019 [cited by applicant]
US 20190151006A1 · Fourkas et al. · 2019 [cited by applicant]
US 20190192873A1 · Schwarz et al. · 2019 [cited by applicant]
US 20190197361A1 · Gonzales et al. · 2019 [cited by applicant]
US 20190254867A1 · Gonzales et al. · 2019 [cited by applicant]
US 20190290347A1 · Elkins et al. · 2019 [cited by applicant]
US 20200046552A1 · Velis et al. · 2020 [cited by applicant]
US 20200069458A1 · Pham · 2020 [cited by applicant]
US 20200138501A1 · DeBenedictis et al. · 2020 [cited by applicant]
US 20200206024A1 · Karnik et al. · 2020 [cited by applicant]
US 20200222103A1 · Manstein · 2020 [cited by applicant]
US 20200268439A1 · Frazier et al. · 2020 [cited by applicant]
US 20200323682A1 · O'Connor et al. · 2020 [cited by applicant]
US 20200375647A1 · Alphandery et al. · 2020 [cited by applicant]
US 20210030457A1 · Avram et al. · 2021 [cited by applicant]
US 20210038278A1 · DeBenedictis et al. · 2021 [cited by applicant]
US 20210128219A1 · Allison et al. · 2021 [cited by applicant]
US 20210186585A1 · Burger et al. · 2021 [cited by applicant]
US 20210282829A1 · O'Neil et al. · 2021 [cited by applicant]
US 20210315626A1 · Xiao et al. · 2021 [cited by applicant]
US 20210322084A1 · Velis et al. · 2021 [cited by applicant]
US 20210353351A1 · Mazor et al. · 2021 [cited by applicant]
US 20220008110A1 · Velis et al. · 2022 [cited by applicant]
US 20220047315A1 · Baker et al. · 2022 [cited by applicant]
US 20220071802A1 · Christopherson et al. · 2022 [cited by applicant]
US 20220125630A1 · Karnik et al. · 2022 [cited by applicant]
US 20220133531A1 · Salma et al. · 2022 [cited by applicant]
US 20220226206A1 · Velis · 2022 [cited by applicant]
US 20220233863A1 · Rondoni et al. · 2022 [cited by applicant]
US 20220257272A1 · Wolf et al. · 2022 [cited by applicant]
US 20220265344A1 · Wolf et al. · 2022 [cited by applicant]
US 20220280788A1 · Verzal et al. · 2022 [cited by applicant]
US 20220288388A1 · Rondoni et al. · 2022 [cited by applicant]
US 20220296887A1 · Johnson et al. · 2022 [cited by applicant]
US 20220338892A1 · Iyer et al. · 2022 [cited by applicant]
US 20220346852A1 · Anderson et al. · 2022 [cited by applicant]
US 20220387091A1 · DeBenedictis et al. · 2022 [cited by applicant]
US 20220401725A1 · Dieken et al. · 2022 [cited by applicant]
US 20220401727A1 · Rondoni et al. · 2022 [cited by applicant]
US 20230000669A1 · Babkin et al. · 2023 [cited by applicant]
US 20230028322A1 · Velis et al. · 2023 [cited by applicant]
US 20230031549A1 · Velis et al. · 2023 [cited by applicant]
US 20230046154A1 · Mazor et al. · 2023 [cited by applicant]
US 20230046673A1 · Velis et al. · 2023 [cited by applicant]
US 20230054472A1 · Hill et al. · 2023 [cited by applicant]
US 20230069123A1 · Soykan et al. · 2023 [cited by applicant]
US 20230218433A1 · Gonzales et al. · 2023 [cited by applicant]
US 20240341830A1 · Kannan et al. · 2024 [cited by applicant]
US 20240341831A1 · Kannan et al. · 2024 [cited by applicant]
US 20250134915A1 · Gonzales et al. · 2025 [cited by applicant]
US 20250135004A1 · Gonzales et al. · 2025 [cited by applicant]
AU 2011279923B2 · 2016 [cited by applicant]
AU 2018226785A1 · 2019 [cited by applicant]
AU 2020272238A1 · 2021 [cited by applicant]
AU 2020412601A1 · 2022 [cited by applicant]
AU 2021324991A1 · 2023 [cited by applicant]
CA 3023821A1 · 2017 [cited by applicant]
CA 3044020A1 · 2018 [cited by applicant]
CA 3065606A1 · 2018 [cited by applicant]
CA 3115260A1 · 2020 [cited by applicant]
CA 3135707A1 · 2020 [cited by applicant]
CA 3162660A1 · 2021 [cited by applicant]
CN 108836619A · 2018 [cited by applicant]
EP 1890627B1 · 2012 [cited by applicant]
EP 2111172B1 · 2013 [cited by applicant]
EP 2094328B1 · 2014 [cited by applicant]
EP 2676623B1 · 2015 [cited by applicant]
EP 2162083B1 · 2015 [cited by applicant]
EP 2499984B1 · 2016 [cited by applicant]
EP 2967706A1 · 2016 [cited by applicant]
EP 2687174B1 · 2016 [cited by applicant]
EP 3099258A1 · 2016 [cited by applicant]
EP 3099260A2 · 2016 [cited by applicant]
EP 3182918A1 · 2017 [cited by applicant]
EP 2802279B1 · 2017 [cited by applicant]
EP 3104796B · 2019 [cited by applicant]
EP 3488833A1 · 2019 [cited by applicant]
EP 3541345A1 · 2019 [cited by applicant]
EP 3342379B1 · 2019 [cited by applicant]
EP 3506846A4 · 2021 [cited by applicant]
EP 3099262B1 · 2022 [cited by applicant]
EP 4081746A1 · 2022 [cited by applicant]
GB 2423023B · 2009 [cited by applicant]
HK 40011648A · 2020 [cited by applicant]
IL 266662A · 2019 [cited by applicant]
IL 269038A · 2019 [cited by applicant]
JP H01223961A · 1989 [cited by applicant]
JP 2022126649A · 2022 [cited by applicant]
MX 2019010396A · 2020 [cited by applicant]
SG 11201908076 · 2019 [cited by applicant]
SG 11202103368 · 2021 [cited by applicant]
SG 11202103636 · 2021 [cited by applicant]
WO 9744092A1 · 1997 [cited by applicant]
WO 9903411A1 · 1999 [cited by applicant]
WO 2003078596A2 · 2003 [cited by applicant]
WO 2007101039A1 · 2007 [cited by applicant]
WO 2007127924A2 · 2007 [cited by applicant]
WO 2007133839A1 · 2007 [cited by applicant]
WO 2008016730A2 · 2008 [cited by applicant]
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WO 2022169699A1 · 2022 [cited by applicant]
WO 2022229277A1 · 2022 [cited by applicant]
WO 2023278891A1 · 2023 [cited by applicant]
WO 2023064528A1 · 2023 [cited by applicant]
Chakrabarti, P. et al., “FoxO1 controls insulin-dependent adipose triglyceride lipase (ATGL) expression and lipolysis in adipocytes,” Journal of biological chemistry, 2009, vol. 284, No. 20, pp. 13296-13300. [cited by applicant]
Decision of Dismissal of Amendment mailed Nov. 12, 2024 in Japanese Patent Application No. 2021-538451, 4 pages, with English Translation. [cited by applicant]
Examination Report mailed Aug. 15, 2024 in Canadian Patent Application No. 3,125,291, 5 pages. [cited by applicant]
Examination Report mailed Aug. 15, 2024 in Canadian Patent Application No. 3,168,812, 4 pages. [cited by applicant]
Examination Report mailed Jul. 10, 2024 in European Patent Application No. 19907538.3, 4 pages. [cited by applicant]
Examination Report mailed Sep. 16, 2024 in Australian Patent Application No. 2019419502, 4 pages. [cited by applicant]
Ichioka, M. et al., “Increased expression of macrophage-inducible C-type lectin in adipose tissue of obese mice and humans,” Diabetes, 2011, vol. 60, pp. 819-826. [cited by applicant]
International Search Report and Written Opinion mailed Jan. 31, 2025 in International Patent Application No. PCT/US24/51836, 10 pages. [cited by applicant]
Keuper, M. et al., “An inflammatory micro-environment promotes human adipocyte apoptosis,” Molecular and cellular endocrinology, 2011, vol. 339, pp. 105-113. [cited by applicant]
Office Action mailed Apr. 16, 2024 in Japanese Patent Application No. 2021-538451, 4 pages, English Translation. [cited by applicant]
Tanaka, M. et al., “Macrophage-inducible C-type lectin underlies obesity-induced adipose tissue fibrosis,” Nature communications, 2014, vol. 5, article:4982, pp. 1-13. [cited by applicant]
Examination Report mailed Jul. 11, 2025 in Canadian Patent Application No. 3,125,291, 4 pages. [cited by applicant]
Invitation to Pay Additional Fees mailed Jul. 21, 2025 in International Patent Application No. PCT/US25/32063, 2 pages. [cited by applicant]
Invitation to Pay Additional Fees mailed Jul. 17, 2025 in International Patent Application No. PCT/US25/32067, 3 pages. [cited by applicant]
Avram, M.M. et al., “Cryolipolysis for Subcutaneous Fat Layer Reduction.” Lasers in Surgery and Medicine, 41: 703-708 (2009). [cited by applicant]
Coleman, S.R. et al., “Clinical Efficacy of Noninvasive Cryolipolysis and Its Effects on Peripheral Nerves.” Aesth. Plast. Surg., 33: 482-488 (2009). [cited by applicant]
Day et al., “Popsicle Panniculitis.” Pediatric Emergency Care; 8(2); 91-93, Apr. 1992. [cited by applicant]
Epstein et al.; Popsicle Panniculitis; NEJM; 282(17); 966-9867; Apr. 23, 1070. [cited by applicant]
Extended European Search Report mailed Apr. 9, 2018 in European Patent Application No. 15846755.5, 9 pages. [cited by applicant]
Extended European Search Report mailed Aug. 19, 2022 in European Patent Application No. 19907538.3, 8 pages. [cited by applicant]
Extended European Search Report mailed Dec. 15, 2023 in European Patent Application No. 21756850.0, 8 pages. [cited by applicant]
Gage et al., “Critical temperature for skin necrosis in experimental cryosurgery.” Cryobiology; 19(3); 273-282, Jun. 1982. [cited by applicant]
International Search Report mailed Dec. 28, 2015 in International Patent Application No. PCT/US15/51903, 10 pages. [cited by applicant]
International Search Report mailed Jun. 29, 2021 in International Patent Application No. PCT/US21/18926, 12 pages. [cited by applicant]
International Search Report mailed Jun. 6, 2023 in International Patent Application No. PCT/US22/82620, 11 pages. [cited by applicant]
International Search Report mailed May 1, 2020 in International Patent Application No. PCT/US19/69113, 11 pages. [cited by applicant]
International Search Report mailed May 16, 2012 in International Patent Application No. PCT/US12/22697. [cited by applicant]
Kim et al., “Tongue fat and its relationship to obstructive sleep apnea.” Sleep 37(10); 1638-1648, Oct. 2014. [cited by applicant]
MEDICALXPRESS: “Study shows that tongue seize and fat may predict sleep apnea risk in obese adults.” 3 pages. Retrieved from the internet on Nov. 27, 2018 at <https://medicalxpress.com/news/2014-09-tongue-size-fat-apnea… [cited by applicant]
Nelson A.A. et al., “Cryolipolysis for Reduction of Excess Adipose Tissue.” Semin. Cutan. Med. Surg., 28: 244-249 (2009). [cited by applicant]
Office Action mailed Jul. 18, 2017 in Canadian Patent Application No. 2,825,624, 3 pages. [cited by applicant]
Office Action mailed Jul. 18, 2018 in Canadian Patent Application No. 2,825,624, 4 pages. [cited by applicant]
Office Action mailed Jul. 25, 2023 in Japanese Patent Application No. 2021-538451, 7 pages, English Translation. [cited by applicant]
Office Action mailed Oct. 27, 2021 in Canadian Patent Application No. 2,962,920, 5 pages. [cited by applicant]
Office Action mailed Sep. 13, 2023 in Canadian Patent Application No. 3,168,812, 4 pages. [cited by applicant]
Office Action mailed Sep. 22, 2023 in Canadian Patent Application No. 3, 125,291, 5 pages. [cited by applicant]
Rajkumar et al., “Popsicle Panniculitis of the Cheeks.” Clinical Pediatrics; 15(7); 619-621; Jul. 1976. [cited by applicant]
Zelickson, B et al., “Cryolipolysis for Noninvasive Fat Cell Destruction: Initial Results from a Pig Model.” Dermatol. Surg., 35: 1462-1470 (2009). [cited by applicant]