Granted Patent
B2
US 12,296,011 · App. 18/313,162 · Granted May 13, 2025
Methods for photodynamic therapy
Assignee:
Sun Pharmaceutical Industries, Inc.
A61K41/0061A61K9/0014A61K9/08A61K31/75A61K47/10A61N5/062A61P17/12A61N2005/0633A61N2005/0642A61N2005/0652A61N2005/0659A61N2005/0663
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Abstract
A method of enhancing penetration of a topical composition of 5-aminolevulinic acid (ALA) into tissue for photodynamic therapy includes topically applying ALA to a treatment area to be treated with photodynamic therapy. The method further includes, after the ALA is applied to the treatment area, covering the treatment area with a low density polyethylene barrier. The treatment area is covered with the low density polyethylene barrier prior to light treatment to minimize transepidermal water loss from the treatment area.
Claims (12)
1. A method of treating a lesion, the method comprising:
providing, via an applicator, a topical composition comprising 5-aminolevulinic acid (ALA);
applying the topical composition comprising the ALA onto a portion of skin containing the lesion, the portion of skin being on an extensor surface of a patient's body, wherein applying the topical composition via the applicator comprises controlling a dispersion of the topical composition;
providing, via the dispersion of the topical composition, uniform wetting of the portion of skin containing the lesion;
incubating the portion of the skin containing the lesion;
applying a barrier directly on the wetted portion of the skin; and
irradiating, via a light source, the portion of skin for a first time period.
2. The method of claim 1 , further comprising determining an accumulation of protoporphyrin IX (PpIX) in the treatment area.
3. The method of claim 1 , wherein the barrier comprises a polyethylene barrier or a foil barrier.
4. The method of claim 1 , wherein a concentration of the ALA within the topical composition is 20% w/w or 10% w/w.
5. The method of claim 1 , wherein irradiating the portion of skin comprises irradiating the portion of skin with a first light wavelength and subsequently irradiating the portion of skin with a second light wavelength.
6. The method of claim 5 , wherein the first light wavelength corresponds to blue light and the second light wavelength corresponds to red light.
Assignments (2)
MERGER
Recorded May 30, 2024
From: DUSA PHARMACEUTICALS, INC.
To: SUN PHARMACEUTICAL INDUSTRIES, INC.
Reel/Frame 067565/0986 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded May 29, 2024
From: LUNDAHL, SCOTT; GUTTADAURO, MICHAEL
To: DUSA PHARMACEUTICALS, INC.
Reel/Frame 067554/0988 →
Continuity (6)
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