Peptide composition and respective uses
The current application discloses a composition that comprises at least one peptide with a sequence length of 6-12 amino acids, where 2-5 of those amino acids are cysteines for the treatment and cosmetics of animal hair, in preference human hair. There are several hair styling methods that involve breakage and reestablishment of disulfide bonds, allowing relaxation and straightening of the hair. However, the most effective methods currently used to modulate hair contain harmful chemicals. Thus, there is a constant demand for formulations that efficiently model the hair fiber without damage. Thus, the present invention aims to provide a composition for treatment of the hair, including animal and human hair, without the use of chemicals harmful to the hair fiber and consumer health and uses of said compositions in shampoo, lotion, serum, cream, conditioner, foam, elixir, oil, aerosol or mask.
1. A method for treating hair, the method comprising:
applying to the hair of a subject a hair composition comprising,
at least one peptide sequence having at least 90% sequence identity with SEQ ID NO: 412 or SEQ ID NO: 409,
wherein the at least one peptide sequence has from about 15% to about 30% cysteine amino acid content.
2. The method of claim 1 , wherein the at least one peptide has about 15-25% cysteine amino acid content.
3. The method of claim 1 , wherein the at least one peptide forms one or more molecular interactions with the hair.
4. The method of claim 3 , wherein the one or more molecular interactions is one or more disulfide bonds.
5. The method of claim 3 , wherein the one or more molecular interactions improves one or more properties of the hair.
6. The method of claim 5 , wherein the one or more properties of the hair is strength, elasticity, or appearance of the hair.
7. The method of claim 3 , wherein the one or more interactions repairs damage to keratinous fiber.
8. The method of claim 1 , wherein the hair composition further comprises at least one excipient suitable for dermatological use.
9. The method of claim 8 , wherein the at least one excipient suitable for dermatological use is selected from the group consisting of non-naturally occurring surfactants, emulsifiers, preservatives, thickeners, organic polymers, humectants, silicones, oils, fragrances, vitamins and buffers.
10. The method of claim 1 , wherein the hair composition is in the form of a shampoo, conditioner, lotion, foam, elixir, spray, gel, mask, aerosol, or any formulation applied with or without subsequent rinsing.
11. The method of claim 1 , wherein the at least one peptide has at least 95% sequence identity with SEQ ID NO: 412 or SEQ ID NO: 409.
12. The method of claim 1 , wherein the at least one peptide is SEQ ID NO: 412 or SEQ ID NO: 409.
13. A method for treating hair, the method comprising:
applying to the hair of a subject a hair composition comprising:
a keratin peptide fragment having 10% to 50% cysteine amino acid content, wherein the total number of cysteine amino acids in the keratin peptide fragment is 2-5 cysteine amino acids and the keratin peptide fragment comprises SEQ ID NO: 5, SEQ ID NO: 409, or SEQ ID NO: 412.
14. The method of claim 13 , wherein the keratin peptide fragment penetrates the hair fiber of the subject.
15. The method of claim 13 , wherein the keratin peptide fragment comprises SEQ ID NO: 412.
16. The method of claim 13 , wherein treating hair comprises the keratin peptide fragment forming one or more disulfide bonds to keratin in the hair of the subject.
17. The method of claim 13 , wherein the keratin peptide fragment is present in the composition at 0.01% to 5% (w/w).
18. The method of claim 13 , wherein the tensile strength of the hair is increased after applying to the hair of the subject the hair composition.
19. The method of claim 13 , wherein the keratin peptide fragment is present in the composition at 0.001% to 20% (w/w).
20. The method of claim 13 , wherein the keratin peptide fragment comprises SEQ ID NO: 409.