Granted Patent B2

US 12,256,957 · App. 18/405,315 · Granted Mar 25, 2025

Inventors: Alec Ginggen (Plymouth, MA); Douglas Levinson (Sherborn, MA)

Assignee: Cytrellis Biosystems, Inc.

A61B17/3417A61B17/205A61B17/545A61B2017/0023A61B2017/00402A61B2017/00424A61B2017/00473A61B2017/00544A61B2017/00734A61B2017/00747A61B2017/00752A61B2017/00756A61B2017/00761A61B2017/00769A61B2017/00796A61B2017/320004A61B17/32002A61B17/3203A61B2017/32035A61B17/32053A61B17/3213A61B2017/3437A61B2017/3454A61B17/3478A61B18/14A61B2018/1807A61B18/203A61B50/13A61B2217/005A61N7/00

Abstract

Claims (29)

1. A method for non-thermal tissue ablation comprising:

a) providing a handheld device having a main body and a tip, wherein said tip comprises one or more sharpened hollow coring needles, the tip being detachably attached to the main body;

b) penetrating into and retracting the one or more sharpened hollow coring needles into a skin to produce a plurality of ablated tissue portions; and

c) driving said one or more sharpened hollow coring needles across a region of the skin in one or two directions that are orthogonal to a longitudinal movement of the one or more sharpened hollow coring needles penetrating into the skin and retracting the one or more sharpened hollow coring needles from the skin, using a translating mechanism disposed in the main body.

2. The method of claim 1 , further comprising establishing fluid communication between the one or more sharpened hollow coring needles and a pressure generating source.

3. The method of claim 2 , further comprising generating a pressure from said pressure generating source of about 0.1 kPa to about 6.0 kPa.

4. The method of claim 3 , further comprising further producing a vacuum using said pressure generating source.

5. The method of claim 2 , wherein said pressure generating source is configured to be positioned at a location that is separate from said handheld device.

6. The method of claim 1 , wherein the one or more sharpened hollow coring needles comprise two or more sharpened hollow coring needles arranged in a 1-dimensional array.

7. The method of claim 1 , wherein the one or more sharpened hollow coring needles comprise three or more sharpened hollow coring needles arranged in a 2-dimensional array.

8. The method of claim 1 , further comprising the one or more sharpened hollow coring needles comprising 1-100 sharpened hollow coring needles.

9. The method of claim 1 , further comprising spacing the one or more coring needles comprising two or more sharpened hollow coring needles about 0.1 to about 5 mm apart.

10. The method of claim 1 , wherein the one or more sharpened hollow coring needles comprise 19-26 gauge needles.

11. The method of claim 10 , wherein the one or more sharpened hollow coring needles comprise 22 or 24 gauge needles.

12. The method of claim 1 , further comprising configuring the one or more sharpened hollow coring needles to provide an ablated tissue portion having a change in width as a function of depth.

13. The method of claim 12 , wherein the width to depth ratio of said ablated tissue portion is between about 1:0.3 and about 1:75.

14. The method of claim 1 , wherein the one or more sharpened hollow coring needles have a width at their widest point of about 0.01 mm to about 2 mm.

15. The method of claim 1 , further comprising configuring the one or more sharpened hollow coring needles to remove about 5% to about 70% of tissue within a treatment area.

16. The method of claim 1 , further comprising configuring the one or more sharpened hollow coring needles to remove about 5% of tissue within a treatment area.

17. The method of claim 1 , further comprising driving penetration of the one or more sharpened hollow coring needles into the skin using an actuation mechanism, wherein said actuation mechanism is mechanically or electrically coupled to said one or more sharpened hollow coring needles.

18. The method of claim 17 , further comprising configuring the actuation mechanism to drive penetration into the skin by said one or more sharpened hollow coring needles to a depth of about 0.1 mm to about 15 mm.

19. The method of claim 18 , further comprising configuring the actuation mechanism to drive penetration into the skin by said one or more sharpened hollow coring needles to a depth of about 2 mm to about 5 mm.

20. The method of claim 17 , further comprising configuring the actuation mechanism to drive penetration into the skin by said one or more sharpened hollow coring needles with a force of about 0.5 N to about 20 N per sharpened hollow coring needle.

21. The method of claim 1 , further comprising using a position detection mechanism.

22. The method of claim 1 , further comprising collecting waste materials at a reservoir.

23. The method of claim 22 , further comprising coupling the handheld device to a base unit.

24. The method of claim 23 , wherein said base unit comprises said reservoir.

25. The method of claim 23 , wherein said base unit comprises a pressure generating source.

26. The method of claim 23 , wherein said base unit comprises a user interface.

Assignments (1)

Continuity (4)

References Cited (400)