IP Library › Granted Patent US 12,365,668
Granted Patent B2
US 12,365,668 · App. 18/430,498 · Granted Jul 22, 2025

Aminopyrazine diol compounds as PI3K-y inhibitors

Inventors: Stacey Shepard (Wilmington, DE); Andrew P. Combs (Kennett Square, PA); Nikoo Falahatpisheh (Wilmington, DE); Lixin Shao (Wilmington, DE)
Assignee: Incyte Corporation
C07D403/04A61P9/00A61P25/28A61P35/00A61P37/02C07B59/002C07D241/20C07D241/28C07D403/08C07D403/14C07D405/12C07D413/04C07D417/04C07B2200/05
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 12,365,668
App. No.
18/430,498
Granted
Jul 22, 2025
Kind
B2
Abstract

This application relates to compounds of Formula (I): or pharmaceutically acceptable salts thereof, which are inhibitors of PI3K-γ which are useful for the treatment of disorders such as autoimmune diseases, cancer, cardiovascular diseases, and neurodegenerative diseases.

Claims (37)

1. A compound, selected from:

2-(3-(5-amino-6-(1-(methyl-d3)-1H-pyrazol-5-yl)pyrazin-2-yl)-4-methylphenyl)-3,3,3-trifluoropropane-1,2-diol;

2-(3-(5-amino-6-(1-methyl-1H-pyrazol-4-yl)pyrazin-2-yl)-4-methylphenyl)-3,3,3-trifluoropropane-1,2-diol;

2-(3-(5-amino-6-(1H-pyrazol-4-yl)pyrazin-2-yl)-4-methylphenyl)-3,3,3-trifluoropropane-1,2-diol;

2-(3-(5-amino-6-(3-methylisoxazol-5-yl)pyrazin-2-yl)-4-methylphenyl)-3,3,3-trifluoropropane-1,2-diol;

2-(3-(5-amino-6-(isothiazol-4-yl)pyrazin-2-yl)-4-methylphenyl)-3,3,3-trifluoropropane-1,2-diol;

2-(3-(5-amino-6-(isothiazol-5-yl)pyrazin-2-yl)-4-methylphenyl)-3,3,3-trifluoropropane-1,2-diol;

2-(3-(5-amino-6-(3-methylisothiazol-5-yl)pyrazin-2-yl)-4-methylphenyl)-3,3,3-trifluoropropane-1,2-diol;

2-(3-(5-amino-6-(2-methyloxazol-5-yl)pyrazin-2-yl)-4-methylphenyl)-3,3,3-trifluoropropane-1,2-diol;

2-(3-(5-amino-6-(2-methylthiazol-5-yl)pyrazin-2-yl)-4-methylphenyl)-3,3,3-trifluoropropane-1,2-diol;

2-(3-(5-amino-6-(oxazol-5-yl)pyrazin-2-yl)-4-methylphenyl)-3,3,3-trifluoropropane-1,2-diol;

2-(3-(5-amino-6-(1H-pyrazol-1-yl)pyrazin-2-yl)-4-methylphenyl)-3,3,3-trifluoropropane-1,2-diol;

2-(3-(5-amino-6-(1H-1,2,3-triazol-1-yl)pyrazin-2-yl)-4-methylphenyl)-3,3,3-trifluoropropane-1,2-diol;

2-(3-(5-amino-6-(2H-1,2,3-triazol-2-yl)pyrazin-2-yl)-4-methylphenyl)-3,3,3-trifluoropropane-1,2-diol;

2-(3-(5-amino-6-(1H-1,2,4-triazol-1-yl)pyrazin-2-yl)-4-methylphenyl)-3,3,3-trifluoropropane-1,2-diol;

2-(3-(5-amino-6-(2-methyloxazol-5-yl)pyrazin-2-yl)-4-(methyl-d3)phenyl)-3,3,3-trifluoropropane-1,2-diol;

2-(3-(5-amino-6-(3-methyl-1H-pyrazol-4-yl)pyrazin-2-yl)-4-(methyl-d3)phenyl)-1,1,1,4,4,4-hexafluorobutane-2,3-diol;

2-(3-(5-amino-6-(1-((1-methyl-1H-pyrazol-3-yl) sulfonyl) azetidin-3-yl)pyrazin-2-yl)-4-methylphenyl)-3,3,3-trifluoropropane-1,2-diol;

(3-(3-amino-6-(2-methyl-5-(1,1,1-trifluoro-2,3-dihydroxypropan-2-yl)phenyl)pyrazin-2-yl)cyclobutyl)(3-hydroxyazetidin-1-yl) methanone; and

2-(3-(5-amino-6-(trifluoromethyl)pyrazin-2-yl)-4-methylphenyl)-3,3,3-trifluoropropane-1,2-diol;

or a pharmaceutically acceptable salt thereof.

2. A pharmaceutical composition comprising a compound of claim 1 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient or carrier.

3. A method of treating a disease or disorder in a patient, wherein the disease or disorder is associated with abnormal expression or activity of PI3Kγ kinase and is selected from the group consisting of colon cancer, gastric cancer, endometrial cancer, pancreatic cancer, renal cancer, breast cancer, skin cancer, head and neck squamous cell carcinoma, liver cancer, bladder cancer, astrocytoma, glioma, pancreatic cancer, and triple negative breast cancer, the method comprising administering to the patient a therapeutically effective amount of a compound of claim 1 , or a pharmaceutically acceptable salt thereof.

4. The method of claim 3 , wherein the disease or disorder is colon cancer.

5. The method of claim 3 , wherein the disease or disorder is gastric cancer.

6. The method of claim 3 , wherein the disease or disorder is endometrial cancer.

7. The method of claim 3 , wherein the disease or disorder is pancreatic cancer.

8. The method of claim 3 , wherein the disease or disorder is renal cancer.

9. The method of claim 3 , wherein the disease or disorder is breast cancer.

10. The method of claim 3 , wherein the disease or disorder is skin cancer.

11. The method of claim 3 , wherein the disease or disorder is head and neck squamous cell carcinoma.

12. The method of claim 3 , wherein the disease or disorder is liver cancer.

13. The method of claim 3 , wherein the disease or disorder is bladder cancer.

14. The method of claim 3 , wherein the disease or disorder is astrocytoma.

15. The method of claim 3 , wherein the disease or disorder is glioma.

16. The method of claim 3 , wherein the disease or disorder is pancreatic cancer.

17. The method of claim 3 , wherein the disease or disorder is triple negative breast cancer.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 13, 2024
From: SHEPARD, STACEY; COMBS, ANDREW P.; FALAHATPISHEH, NIKOO; SHAO, LIXIN
To: INCYTE CORPORATION
Reel/Frame 066448/0289 →
Continuity (7)
Continuation 17540860 · Dec 2, 2021
Continuation 16847975 · Apr 14, 2020
Continuation 16295705 · Mar 7, 2019
Provisional Application 62745873 · Oct 15, 2018
Provisional Application 62702230 · Jul 23, 2018
Provisional Application 62640276 · Mar 8, 2018
Related Publication 20240400541A1 · Dec 5, 2024
References Cited (400)
US 4705853A · Cale · 1987 [cited by applicant]
US 4861884A · Treybig · 1989 [cited by applicant]
US 4921860A · Cliffe · 1990 [cited by applicant]
US 4971909A · Kaneoya et al. · 1990 [cited by applicant]
US 5025096A · Chiu et al. · 1991 [cited by applicant]
US 5155117A · Reitz · 1992 [cited by applicant]
US 5232945A · Hulin · 1993 [cited by applicant]
US 5252737A · Stern et al. · 1993 [cited by applicant]
US 5315043A · Fernandez et al. · 1994 [cited by applicant]
US 5393860A · Kvakovszky et al. · 1995 [cited by applicant]
US 5430123A · Kvakovszky et al. · 1995 [cited by applicant]
US 5436134A · Haugland et al. · 1995 [cited by applicant]
US 5459266A · Kvakovszky et al. · 1995 [cited by applicant]
US 5521056A · Buchanan et al. · 1996 [cited by applicant]
US 5521184A · Zimmerman · 1996 [cited by applicant]
US 5534416A · Millard et al. · 1996 [cited by applicant]
US 5545535A · Ruth et al. · 1996 [cited by applicant]
US 5602156A · Kohn et al. · 1997 [cited by applicant]
US 5621027A · Roschger et al. · 1997 [cited by applicant]
US 5656449A · Yue · 1997 [cited by applicant]
US 5672592A · Jackson et al. · 1997 [cited by applicant]
US 5677459A · McDonald et al. · 1997 [cited by applicant]
US 5705512A · McDonald et al. · 1998 [cited by applicant]
US 5716971A · Shiraishi et al. · 1998 [cited by applicant]
US 5723477A · McDonald et al. · 1998 [cited by applicant]
US 5756508A · Thompson et al. · 1998 [cited by applicant]
US 5811442A · Bencherif et al. · 1998 [cited by applicant]
US 5863903A · Lundgren et al. · 1999 [cited by applicant]
US 5869487A · Coburn et al. · 1999 [cited by applicant]
US 5880137A · Miller et al. · 1999 [cited by applicant]
US 5883106A · Stevens et al. · 1999 [cited by applicant]
US 5929075A · Heeres et al. · 1999 [cited by applicant]
US 6172084B1 · Cuny et al. · 2001 [cited by applicant]
US 6197798B1 · Fink et al. · 2001 [cited by applicant]
US 6207679B1 · Cuny et al. · 2001 [cited by applicant]
US 6274598B1 · Ellis et al. · 2001 [cited by applicant]
US 6559167B1 · Garst et al. · 2003 [cited by applicant]
US 7745437B2 · Ren et al. · 2010 [cited by applicant]
US 7872031B2 · Lauffer et al. · 2011 [cited by applicant]
US 8232406B2 · Lauffer et al. · 2012 [cited by applicant]
US 8410112B2 · Charrier et al. · 2013 [cited by applicant]
US 8741931B2 · Jimenez et al. · 2014 [cited by applicant]
US 8841308B2 · Charrier et al. · 2014 [cited by applicant]
US 8841337B2 · Charrier et al. · 2014 [cited by applicant]
US 8841450B2 · Charrier et al. · 2014 [cited by applicant]
US 8846917B2 · Charrier et al. · 2014 [cited by applicant]
US 8846918B2 · Charrier et al. · 2014 [cited by applicant]
US 8962623B2 · Shetty et al. · 2015 [cited by applicant]
US 8969356B2 · Charrier et al. · 2015 [cited by applicant]
US 9035053B2 · Charrier et al. · 2015 [cited by applicant]
US 9096584B2 · Charrier et al. · 2015 [cited by applicant]
US 9365557B2 · Charrier et al. · 2016 [cited by applicant]
US 9701674B2 · Charrier et al. · 2017 [cited by applicant]
US 10669262B2 · Shepard et al. · 2020 [cited by applicant]
US 11046658B2 · Douty et al. · 2021 [cited by applicant]
US 11926616B2 · Shepard et al. · 2024 [cited by applicant]
US 20020103141A1 · McKearn et al. · 2002 [cited by applicant]
US 20020115678A1 · Ellis et al. · 2002 [cited by applicant]
US 20020169072A1 · Nakayama et al. · 2002 [cited by applicant]
US 20030008828A1 · Priestley et al. · 2003 [cited by applicant]
US 20030027798A1 · Druzgala et al. · 2003 [cited by applicant]
US 20030225142A1 · Crooks et al. · 2003 [cited by applicant]
US 20040082641A1 · Rytved et al. · 2004 [cited by applicant]
US 20040106621A1 · Wu et al. · 2004 [cited by applicant]
US 20040127519A1 · Reinhard et al. · 2004 [cited by applicant]
US 20040127719A1 · Yang et al. · 2004 [cited by applicant]
US 20040158065A1 · Berth et al. · 2004 [cited by applicant]
US 20040229873A1 · Harbige et al. · 2004 [cited by applicant]
US 20050048312A1 · Herron et al. · 2005 [cited by applicant]
US 20050069551A1 · Shoji et al. · 2005 [cited by applicant]
US 20050234046A1 · Zhao et al. · 2005 [cited by applicant]
US 20050234389A1 · Bouwstra et al. · 2005 [cited by applicant]
US 20050239826A1 · Stenkamp et al. · 2005 [cited by applicant]
US 20050282825A1 · Malamas et al. · 2005 [cited by applicant]
US 20050282826A1 · Malamas et al. · 2005 [cited by applicant]
US 20060205736A1 · Noble et al. · 2006 [cited by applicant]
US 20060270686A1 · Kelly et al. · 2006 [cited by applicant]
US 20070010573A1 · Kong et al. · 2007 [cited by applicant]
US 20070015752A1 · Hangauer · 2007 [cited by applicant]
US 20070039644A1 · Lee et al. · 2007 [cited by applicant]
US 20070060613A1 · Kim · 2007 [cited by applicant]
US 20070066619A1 · Hamilton et al. · 2007 [cited by applicant]
US 20070143936A1 · Lagrange · 2007 [cited by applicant]
US 20070190358A1 · Byun et al. · 2007 [cited by applicant]
US 20080009527A1 · Dumas et al. · 2008 [cited by applicant]
US 20080103074A1 · Stokes et al. · 2008 [cited by applicant]
US 20080184495A1 · Brun et al. · 2008 [cited by applicant]
US 20080255389A1 · Coggan et al. · 2008 [cited by applicant]
US 20080280891A1 · Kelly et al. · 2008 [cited by applicant]
US 20080281075A1 · Harwood et al. · 2008 [cited by applicant]
US 20080293739A1 · Trede · 2008 [cited by applicant]
US 20080300419A1 · Chen et al. · 2008 [cited by applicant]
US 20090011991A1 · Shoji et al. · 2009 [cited by applicant]
US 20090048280A1 · Burgoon, Jr. et al. · 2009 [cited by applicant]
US 20090093479A1 · Kelly et al. · 2009 [cited by applicant]
US 20090124602A1 · Maltais et al. · 2009 [cited by applicant]
US 20090124805A1 · Alleyne · 2009 [cited by applicant]
US 20090149653A1 · Cheng et al. · 2009 [cited by applicant]
US 20090163463A1 · Bruce et al. · 2009 [cited by applicant]
US 20090272946A1 · Lu · 2009 [cited by applicant]
US 20100036172A1 · Hung et al. · 2010 [cited by applicant]
US 20100056576A1 · Burger et al. · 2010 [cited by applicant]
US 20100099825A1 · Schmitz et al. · 2010 [cited by applicant]
US 20100160669A1 · Liu et al. · 2010 [cited by applicant]
US 20100184986A1 · Carter et al. · 2010 [cited by applicant]
US 20100273764A1 · Andrews et al. · 2010 [cited by applicant]
US 20110049497A1 · Ise · 2011 [cited by applicant]
US 20110082165A1 · Ellsworth et al. · 2011 [cited by applicant]
US 20110124663A1 · Conn et al. · 2011 [cited by applicant]
US 20110277841A1 · Chi et al. · 2011 [cited by applicant]
US 20110306707A1 · Benton et al. · 2011 [cited by applicant]
US 20120122708A1 · Castells et al. · 2012 [cited by applicant]
US 20120129888A1 · Castells et al. · 2012 [cited by applicant]
US 20120142930A1 · Castells et al. · 2012 [cited by applicant]
US 20120289481A1 · O'Neil et al. · 2012 [cited by applicant]
US 20130004859A1 · Yu et al. · 2013 [cited by applicant]
US 20130035323A1 · Amberg et al. · 2013 [cited by applicant]
US 20130056716A1 · Cheng et al. · 2013 [cited by applicant]
US 20130066029A1 · Radlauer et al. · 2013 [cited by applicant]
US 20130115311A1 · Charrier et al. · 2013 [cited by applicant]
US 20130115312A1 · Charrier et al. · 2013 [cited by applicant]
US 20130115313A1 · Charrier et al. · 2013 [cited by applicant]
US 20130115314A1 · Charrier et al. · 2013 [cited by applicant]
US 20130158031A1 · Cai et al. · 2013 [cited by applicant]
US 20130158067A1 · Woller et al. · 2013 [cited by applicant]
US 20130224121A1 · Fukui et al. · 2013 [cited by applicant]
US 20130261106A1 · Carry et al. · 2013 [cited by applicant]
US 20130267521A1 · Castro et al. · 2013 [cited by applicant]
US 20140088117A1 · Burch et al. · 2014 [cited by applicant]
US 20140117318A1 · Choi et al. · 2014 [cited by applicant]
US 20140148484A1 · Schnapp et al. · 2014 [cited by applicant]
US 20140171525A1 · Yu et al. · 2014 [cited by applicant]
US 20140178815A1 · Jung et al. · 2014 [cited by applicant]
US 20140200227A1 · Xue et al. · 2014 [cited by applicant]
US 20140249132A1 · Li et al. · 2014 [cited by applicant]
US 20140275070A1 · Grembecka et al. · 2014 [cited by applicant]
US 20140275167A1 · Hartman · 2014 [cited by applicant]
US 20140288067A1 · Chesworth et al. · 2014 [cited by applicant]
US 20150057300A1 · Tafesse et al. · 2015 [cited by applicant]
US 20150137096A1 · Xia et al. · 2015 [cited by applicant]
US 20150141434A1 · Park · 2015 [cited by applicant]
US 20150171349A1 · Ma et al. · 2015 [cited by applicant]
US 20150197513A1 · Wrasidlo et al. · 2015 [cited by applicant]
US 20150249222A1 · Szigethy et al. · 2015 [cited by applicant]
US 20150306227A1 · Cruise et al. · 2015 [cited by applicant]
US 20150322076A1 · Chen et al. · 2015 [cited by applicant]
US 20150342951A1 · Cooke et al. · 2015 [cited by applicant]
US 20150359797A1 · Helleday et al. · 2015 [cited by applicant]
US 20160122302A1 · Silverman et al. · 2016 [cited by applicant]
US 20160176857A1 · Ly · 2016 [cited by applicant]
US 20160200731A1 · Mickle et al. · 2016 [cited by applicant]
US 20160246152A1 · Igawa et al. · 2016 [cited by applicant]
US 20160311809A1 · Charrier et al. · 2016 [cited by applicant]
US 20160340311A1 · Biswas et al. · 2016 [cited by applicant]
US 20160359122A1 · Boudreault et al. · 2016 [cited by applicant]
US 20170092880A1 · Boudreault et al. · 2017 [cited by applicant]
US 20170101394A1 · Zhang · 2017 [cited by applicant]
US 20170101395A1 · Zhang · 2017 [cited by applicant]
US 20170101403A1 · Zhang · 2017 [cited by applicant]
US 20170186964A1 · Cho et al. · 2017 [cited by applicant]
US 20170186975A1 · Kim et al. · 2017 [cited by applicant]
US 20170190689A1 · Sparks et al. · 2017 [cited by applicant]
US 20170204080A1 · Chen et al. · 2017 [cited by applicant]
US 20170232016A1 · Zou et al. · 2017 [cited by applicant]
US 20170275278A1 · Silverman et al. · 2017 [cited by applicant]
US 20170294597A1 · Tsai et al. · 2017 [cited by applicant]
US 20170305861A1 · Kim et al. · 2017 [cited by applicant]
US 20180086709A1 · Choi et al. · 2018 [cited by applicant]
US 20180173922A1 · Ghavanini et al. · 2018 [cited by applicant]
US 20190276435A1 · Shepard et al. · 2019 [cited by applicant]
US 20200002295A1 · Douty et al. · 2020 [cited by applicant]
US 20200339542A1 · Shepard et al. · 2020 [cited by applicant]
US 20220213065A1 · Shepard et al. · 2022 [cited by applicant]
US 20220411383A1 · Douty et al. · 2022 [cited by applicant]
AR 86653 · 2014 [cited by applicant]
CA 2464604 · 2004 [cited by applicant]
CA 2956996 · 2016 [cited by applicant]
CL 201400517 · 2014 [cited by applicant]
CL 201400498 · 2014 [cited by applicant]
CN 1374306 · 2002 [cited by applicant]
CN 101058577 · 2007 [cited by applicant]
CN 101384586 · 2009 [cited by applicant]
CN 101513584 · 2009 [cited by applicant]
CN 101591332 · 2009 [cited by applicant]
CN 101712809 · 2010 [cited by applicant]
CN 101781200 · 2010 [cited by applicant]
CN 102125875 · 2011 [cited by applicant]
CN 102260218 · 2011 [cited by applicant]
CN 102428087 · 2012 [cited by applicant]
CN 102548984 · 2012 [cited by applicant]
CN 102850328 · 2013 [cited by applicant]
CN 103087050 · 2013 [cited by applicant]
CN 103193702 · 2013 [cited by applicant]
CN 103524372 · 2014 [cited by applicant]
CN 103588771 · 2014 [cited by applicant]
CN 103664878 · 2014 [cited by applicant]
CN 103694236 · 2014 [cited by applicant]
CN 103804312 · 2014 [cited by applicant]
CN 103848838 · 2014 [cited by applicant]
CN 103923085 · 2014 [cited by applicant]
CN 104004026 · 2014 [cited by applicant]
CN 104557863 · 2015 [cited by applicant]
CN 104703979 · 2015 [cited by applicant]
CN 104744348 · 2015 [cited by applicant]
CN 104926788 · 2015 [cited by applicant]
CN 104927742 · 2015 [cited by applicant]
CN 105175202 · 2015 [cited by applicant]
CN 105315199 · 2016 [cited by applicant]
CN 106831735 · 2017 [cited by applicant]
CN 106905299 · 2017 [cited by applicant]
CO 6331431 · 2011 [cited by applicant]
CO 6640285 · 2013 [cited by applicant]
DE 3628223 · 1987 [cited by applicant]
DE 19509353 · 1995 [cited by applicant]
DE 19718742 · 1998 [cited by applicant]
DE 102009055828 · 2010 [cited by applicant]
DE 102010054892 · 2012 [cited by applicant]
DE 102012006896 · 2013 [cited by applicant]
EP 0553009 · 1993 [cited by applicant]
EP 0695743 · 1996 [cited by applicant]
EP 0808838 · 1997 [cited by applicant]
EP 0827135 · 1998 [cited by applicant]
EP 0879814 · 1998 [cited by applicant]
EP 0930302 · 1999 [cited by applicant]
EP 1837330 · 2007 [cited by applicant]
EP 2396307 · 2011 [cited by applicant]
EP 2524918 · 2012 [cited by applicant]
EP 2723722 · 2014 [cited by applicant]
EP 3051604 · 2016 [cited by applicant]
EP 3116506 · 2017 [cited by applicant]
EP 3128041 · 2017 [cited by applicant]
ES 2379919 · 2012 [cited by applicant]
GB 2290489 · 1996 [cited by applicant]
IN 110DEL2012 · 2015 [cited by applicant]
IT 2006MI0895 · 2006 [cited by applicant]
IT MI20110208 · 2012 [cited by applicant]
JP 05058997 · 1993 [cited by applicant]
JP 06001776 · 1994 [cited by applicant]
JP H06256327 · 1994 [cited by applicant]
JP H06340642 · 1994 [cited by applicant]
JP 07082249 · 1995 [cited by applicant]
JP H08175994 · 1996 [cited by applicant]
JP H08337583 · 1996 [cited by applicant]
JP H10188264 · 1998 [cited by applicant]
JP H10324687 · 1998 [cited by applicant]
JP H11292883 · 1999 [cited by applicant]
JP 2000073094 · 2000 [cited by applicant]
JP 2000076640 · 2000 [cited by applicant]
JP 2000076642 · 2000 [cited by applicant]
JP 2000076643 · 2000 [cited by applicant]
JP 2001072660 · 2001 [cited by applicant]
JP 2001089460 · 2001 [cited by applicant]
JP 2001247548 · 2001 [cited by applicant]
JP 2002338837 · 2002 [cited by applicant]
JP 2003012645 · 2003 [cited by applicant]
JP 2003040809 · 2003 [cited by applicant]
JP 2003212706 · 2003 [cited by applicant]
JP 2003292408 · 2003 [cited by applicant]
JP 3502629 · 2004 [cited by applicant]
JP 2004067540 · 2004 [cited by applicant]
JP 2004123617 · 2004 [cited by applicant]
JP 2004143061 · 2004 [cited by applicant]
JP 2004143163 · 2004 [cited by applicant]
JP 2004196670 · 2004 [cited by applicant]
JP 2005029500 · 2005 [cited by applicant]
JP 2005126586 · 2005 [cited by applicant]
JP 2006041020 · 2006 [cited by applicant]
JP 2007039388 · 2007 [cited by applicant]
JP 2007145819 · 2007 [cited by applicant]
JP 2007161674 · 2007 [cited by applicant]
JP 2009001742 · 2009 [cited by applicant]
JP 2009007342 · 2009 [cited by applicant]
JP 2009023986 · 2009 [cited by applicant]
JP 2010143829 · 2010 [cited by applicant]
JP 2012036125 · 2012 [cited by applicant]
JP 2012525395 · 2012 [cited by applicant]
JP 2013129651 · 2013 [cited by applicant]
JP 2013129653 · 2013 [cited by applicant]
JP 2014001205 · 2014 [cited by applicant]
JP 2014015447 · 2014 [cited by applicant]
JP 2014037382 · 2014 [cited by applicant]
JP 2014078381 · 2014 [cited by applicant]
JP 2014078382 · 2014 [cited by applicant]
JP 2014111559 · 2014 [cited by applicant]
JP 2014198841 · 2014 [cited by applicant]
JP 2014198843 · 2014 [cited by applicant]
JP 2014198844 · 2014 [cited by applicant]
JP 2015003895 · 2015 [cited by applicant]
JP 2015017236 · 2015 [cited by applicant]
JP 2015043445 · 2015 [cited by applicant]
JP 2015512940 · 2015 [cited by applicant]
JP 2015122247 · 2015 [cited by applicant]
JP 2015125845 · 2015 [cited by applicant]
JP 2015141806 · 2015 [cited by applicant]
JP 2015193569 · 2015 [cited by applicant]
JP 2016124730 · 2016 [cited by applicant]
JP 2017019789 · 2017 [cited by applicant]
JP 2017513889 · 2017 [cited by applicant]
JP 2021500340 · 2021 [cited by applicant]
KR 20080049767 · 2008 [cited by applicant]
KR 20100001274 · 2010 [cited by applicant]
KR 20120063028 · 2012 [cited by applicant]
KR 20130122361 · 2013 [cited by applicant]
KR 20160126792 · 2016 [cited by applicant]
KR 20170036233 · 2017 [cited by applicant]
KR 20170093273 · 2017 [cited by applicant]
TW I388566 · 2013 [cited by applicant]
WO WO199829114 · 1988 [cited by applicant]
WO WO199117979 · 1991 [cited by applicant]
WO WO199422853 · 1994 [cited by applicant]
WO WO199424213 · 1994 [cited by applicant]
WO WO199425425 · 1994 [cited by applicant]
WO WO199507695 · 1995 [cited by applicant]
WO WO199508327 · 1995 [cited by applicant]
WO WO199524391 · 1995 [cited by applicant]
WO WO199529155 · 1995 [cited by applicant]
WO WO199534564 · 1995 [cited by applicant]
WO WO199611910 · 1996 [cited by applicant]
WO WO199611911 · 1996 [cited by applicant]
WO WO199613499 · 1996 [cited by applicant]
WO WO199615123 · 1996 [cited by applicant]
WO WO199618394 · 1996 [cited by applicant]
WO WO199621651 · 1996 [cited by applicant]
WO WO199637486 · 1996 [cited by applicant]
WO WO199701538 · 1997 [cited by applicant]
WO WO199711943 · 1997 [cited by applicant]
WO WO199712864 · 1997 [cited by applicant]
WO WO199716187 · 1997 [cited by applicant]
WO WO199716192 · 1997 [cited by applicant]
WO WO199721702 · 1997 [cited by applicant]
WO WO199726258 · 1997 [cited by applicant]
WO WO199733872 · 1997 [cited by applicant]
WO WO199743267 · 1997 [cited by applicant]
WO WO199805642 · 1998 [cited by applicant]
WO WO199807702 · 1998 [cited by applicant]
WO WO199813361 · 1998 [cited by applicant]
WO WO199814436 · 1998 [cited by applicant]
WO WO199817274 · 1998 [cited by applicant]
WO WO199818326 · 1998 [cited by applicant]
WO WO199827098 · 1998 [cited by applicant]
WO WO199835961 · 1998 [cited by applicant]
WO WO199855480 · 1998 [cited by applicant]
WO WO199901453 · 1999 [cited by applicant]
WO WO199902503 · 1999 [cited by applicant]
WO WO199915169 · 1999 [cited by applicant]
WO WO199927930 · 1999 [cited by applicant]
WO WO199932110 · 1999 [cited by applicant]
WO WO199932117 · 1999 [cited by applicant]
WO WO199932455 · 1999 [cited by applicant]
WO WO199933810 · 1999 [cited by applicant]
WO WO199938829 · 1999 [cited by applicant]
WO WO199955313 · 1999 [cited by applicant]
WO WO199957113 · 1999 [cited by applicant]
WO WO199963984 · 1999 [cited by applicant]
WO WO199964407 · 1999 [cited by applicant]
WO WO200005201 · 2000 [cited by applicant]
WO WO2000009495 · 2000 [cited by applicant]
WO WO200009498 · 2000 [cited by applicant]
WO WO200015615 · 2000 [cited by applicant]
WO WO200025139 · 2000 [cited by applicant]
WO WO200034230 · 2000 [cited by applicant]
WO WO200034277 · 2000 [cited by applicant]
WO WO200039094 · 2000 [cited by applicant]
WO WO200043405 · 2000 [cited by applicant]
WO WO2000053595 · 2000 [cited by applicant]
WO WO200104076 · 2001 [cited by applicant]
WO WO200107407 · 2001 [cited by applicant]
WO WO2001014402 · 2001 [cited by applicant]
WO WO200116122 · 2001 [cited by applicant]
WO WO200132658 · 2001 [cited by applicant]
WO WO200136415 · 2001 [cited by applicant]
WO WO200140188 · 2001 [cited by applicant]
WO WO2001064655 · 2001 [cited by applicant]
WO WO200181328 · 2001 [cited by applicant]
WO WO200187853 · 2001 [cited by applicant]
WO WO2002000196 · 2002 [cited by applicant]
WO WO200200648 · 2002 [cited by applicant]
WO WO200206271 · 2002 [cited by applicant]
WO WO200208199 · 2002 [cited by applicant]
WO WO200209759 · 2002 [cited by applicant]
WO WO200220501 · 2002 [cited by applicant]
WO WO200224689 · 2002 [cited by applicant]
WO WO2002038628 · 2002 [cited by applicant]
WO WO2002042272 · 2002 [cited by applicant]
WO WO2002042306 · 2002 [cited by applicant]
WO WO2002046162 · 2002 [cited by applicant]
WO WO2002060877 · 2002 [cited by applicant]
WO WO2002069712 · 2002 [cited by applicant]
WO WO2002070514 · 2002 [cited by applicant]
WO WO2002072543 · 2002 [cited by applicant]
WO WO2002076395 · 2002 [cited by applicant]
WO WO2002079143 · 2002 [cited by applicant]
WO WO2002089738 · 2002 [cited by applicant]
WO WO2003004475 · 2003 [cited by applicant]
WO WO2003024441 · 2003 [cited by applicant]
WO WO2003024967 · 2003 [cited by applicant]
WO WO2003028684 · 2003 [cited by applicant]
WO WO2003034824 · 2003 [cited by applicant]
WO WO2003037347 · 2003 [cited by applicant]
WO WO2003040257 · 2003 [cited by applicant]