System and method for non-invasive monitoring of hemoglobin
A method of non-invasively monitoring hemoglobin concentration includes providing incident light to patient tissue at a first excitation wavelength. The method further includes monitoring a first emission response at a first emission wavelength, wherein the first emission wavelength is selected to correspond with a maximum of the emission response, and monitoring a second emission response at a second emission wavelength, wherein the second emission wavelength is selected to correspond with a minimum of the emission response. A hemoglobin concentration is calculated based on a ratio of the first emission response to the second emission response.
1. A system comprising:
a medical device comprising:
one or more light sources configured to provide incident light to a patient at a first excitation wavelength and a second excitation wavelength; and
a photodetector configured to:
monitor emissions in response to the first excitation wavelength at an emission wavelength; and
monitor emissions in response to the second excitation wavelength at the emission wavelength; and
one or more processors configured to determine a physiological parameter based on a ratio of emissions at the emission wavelength monitored in response to the first excitation wavelength and emissions at the emission wavelength monitored in response to the second excitation wavelength.
2. The system of claim 1 , wherein the physiological parameter is a blood protein measurement.
3. The system of claim 1 , wherein the physiological parameter is a fluid measurement.
4. The system of claim 1 , wherein the physiological parameter is a component concentration measurement.
5. The system of claim 1 , wherein the physiological parameter is a blood measurement.
6. The system of claim 1 , wherein the physiological parameter is a protein measurement.
7. The system of claim 1 , wherein the physiological parameter is a photo-active molecule measurement.
8. The system of claim 1 , wherein the emission wavelength is configured to detect the physiological parameter.
9. The system of claim 1 , wherein the one or more processors are configured to:
determine that the physiological parameter has fallen below a threshold value; and
generate an alert in response to the determination that the physiological parameter has fallen below the threshold value.
10. The system of claim 9 , wherein the alert indicates a change in a patient condition.
11. The system of claim 1 , wherein the one or more processors are configured to:
determine a plurality of measurements of the physiological parameter over time during a monitoring period based on a plurality of ratios of emissions at the emission wavelength monitored in response to the first excitation wavelength and emissions at the emission wavelength monitored in response to the second excitation wavelength at respective times during the monitoring period; and
provide an output indicating a trend in physiological parameter measurements over the monitoring period.
12. The system of claim 1 ,
wherein the physiological parameter comprises a first physiological parameter,
wherein the medical device comprises one or more sensors configured to sense one or more additional physiological parameters comprising one or more of an electrocardiogram (ECG) signal, respiration rate, bio-impedance level, activity level, posture, or temperature of the patient, and
wherein the one or more processors are configured to determine a patient condition based on the first physiological parameter and the one or more additional physiological parameters comprising one or more of the ECG signal, respiration rate, bio-impedance level, activity level, posture, or temperature.
13. The system of claim 1 , wherein the medical device is configured for implantation within the patient.
14. A method performed by a medical device comprising processing circuitry and being configured to determine a physiological parameter of a patient, the method comprising:
providing incident light, by one or more light sources of the medical device, to the patient at a first excitation wavelength;
monitoring emissions, by one or more photodetectors of the medical device, in response to the first excitation wavelength at an emission wavelength;
providing incident light, by the one or more light sources, to the patient at a second excitation wavelength;
monitoring emissions, by the one or more photodetectors, in response to the second excitation wavelength at the emission wavelength; and
determining, by the processing circuitry, the physiological parameter based on a ratio of emissions at the emission wavelength monitored in response to the first excitation wavelength and emissions at the emission wavelength monitored in response to the second excitation wavelength.
15. The method of claim 14 , wherein the physiological parameter is a blood protein measurement.
16. The method of claim 14 , wherein the physiological parameter is a fluid measurement.
17. The method of claim 14 , wherein the physiological parameter is a component concentration measurement.
18. The method of claim 14 , wherein the physiological parameter is a blood measurement.
19. The method of claim 14 , wherein the physiological parameter is a protein measurement.
20. The method of claim 14 , wherein the physiological parameter is a photo-active molecule measurement.
21. The method of claim 14 , wherein the emission wavelength is configured to detect the physiological parameter.
22. The method of claim 14 , further comprising:
determining, by the processing circuitry, that the physiological parameter has fallen below a threshold value; and
generating, by the processing circuitry, an alert in response to the determination that the physiological parameter has fallen below the threshold value.
23. The method of claim 14 , wherein generating the alert comprises generating an alert of a change in a patient condition.
24. The method of claim 14 , wherein determining the physiological parameter comprises:
determining a plurality of measurements of the physiological parameter over time during a monitoring period based on a plurality of ratios of emissions at the emission wavelength monitored in response to the first excitation wavelength and emissions at the emission wavelength monitored in response to the second excitation wavelength at respective times during the monitoring period; and
providing an output, by the processing circuitry, indicating a trend in the physiological parameter over the monitoring period.
25. The method of claim 14 , wherein the physiological parameter comprises a first physiological parameter, the method further comprising:
sensing, by the medical device, one or more additional physiological parameters comprising one or more of an electrocardiogram (ECG) signal, respiration rate, bio-impedance level, activity level, posture, or temperature of the patient; and
determining, by the processing circuitry, a patient condition based on the first physiological parameter and the one or more additional physiological parameters comprising one of more of the ECG signal, respiration rate, bio-impedance level, activity level, posture, or temperature.