IP Library › Granted Patent US 12,466,897
Granted Patent B2
US 12,466,897 · App. 19/087,398 · Granted Nov 11, 2025

Heterodimeric human IgG1 polypeptides with isoelectric point modifications

Inventors: Gregory L. Moore (Monrovia, CA); Gregory Lazar (Pacifica, CA)
Assignee: Xencor, Inc.
C07K16/468C07K16/00C07K14/521C07K14/522C07K14/523C07K14/525C07K14/535C07K14/54C07K14/5428C07K14/5434C07K14/55C07K14/70521C07K14/7151C07K14/745C07K14/755C07K16/22C07K16/2803C07K16/2809C07K16/283C07K16/2878C07K2317/31C07K2317/35C07K2317/52C07K2317/94C07K2319/30
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Quick Facts
Patent No.
US 12,466,897
App. No.
19/087,398
Granted
Nov 11, 2025
Kind
B2
Abstract

The invention relates generally to compositions and methods for purifying the desired species from a mixture of desired heterodimer and contaminating homodimer immunoglobulin variants by modifying the isoelectric point(s) of the individual chains.

Claims (1)

1 . A composition comprising a variant human IgG1 Fc region comprising the amino acid substitutions L351K and T366K, wherein numbering is according to the EU index, and wherein said variant human IgG1 Fc region has at least 95% sequence identity to SEQ ID NO: 2.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 8, 2025
From: MOORE, GREGORY; LAZAR, GREGORY
To: XENCOR, INC.
Reel/Frame 072511/0164 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 19, 2025
From: BERNETT, MATTHEW J.; MOORE, GREGORY L.; DESJARLAIS, JOHN; RASHID, RUMANA
To: XENCOR, INC.
Reel/Frame 072319/0289 →
Continuity (7)
Continuation 17068441 · Oct 12, 2020
Continuation 13648951 · Oct 10, 2012
Continuation In Part 13568028 · Aug 6, 2012
Provisional Application 61598686 · Feb 14, 2012
Provisional Application 61593846 · Feb 1, 2012
Provisional Application 61545498 · Oct 10, 2011
Related Publication 20250230262A1 · Jul 17, 2025
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