IP Library › Granted Patent US 12,427,160
Granted Patent B2
US 12,427,160 · App. 19/187,858 · Granted Sep 30, 2025

Use of cannabinoids in the treatment of epilepsy

Inventors: Geoffrey Guy (Cambridge, GB); Stephen Wright (Altrincham, GB); Orrin Devinsky (New York, NY)
Assignee: JAZZ PHARMACEUTICALS RESEARCH UK LIMITED
A61K31/05A61K9/08A61K31/352A61K45/06A61K47/10
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Quick Facts
Patent No.
US 12,427,160
App. No.
19/187,858
Granted
Sep 30, 2025
Kind
B2
Abstract

The present disclosure relates to the use of cannabidiol (CBD) for the treatment of atonic seizures. In particular the CBD appears particularly effective in reducing atonic seizures in patients suffering with etiologies that include: Lennox-Gastaut Syndrome; Tuberous Sclerosis Complex; Dravet Syndrome; Doose Syndrome; Aicardi syndrome; CDKL5 and Dup15q in comparison to other seizure types. The disclosure further relates to the use of CBD in combination with one or more anti-epileptic drugs (AEDs).

Claims (30)

1. A method of treating seizures associated with juvenile myoclonic epilepsy in a patient in need thereof, comprising administering to the patient a pharmaceutical composition comprising a cannabidiol (CBD) drug substance, wherein the CBD drug substance comprises at least 98% w/w CBD; and

wherein the dose of CBD administered to the patient ranges from about 5 mg/kg/day to about 25 mg/kg/day.

2. The method of claim 1 , wherein the CBD drug substance comprises not more than 0.15% w/w CBDA.

3. The method of claim 1 , wherein the CBD drug substance comprises not more than 1.0% w/w CBDV.

4. The method of claim 1 , wherein the CBD drug substance comprises not more than 0.15% w/w Δ9THC.

5. The method of claim 1 , wherein the CBD drug substance comprises not more than 0.5% w/w CBD-C4.

6. The method of claim 1 , wherein the CBD drug substance comprises not more than 1.0% w/w CBDV and not more than 0.15% w/w Δ9THC.

7. The method of claim 1 , wherein the CBD drug substance comprises not more than 1.0% w/w CBDV, not more than 0.15% w/w Δ9THC, and not more than 0.5% w/w CBD-C4.

8. The method of claim 1 , wherein the CBD drug substance comprises not more than 0.15% w/w CBDA, not more than 1.0% w/w CBDV, not more than 0.15% w/w Δ9THC, and not more than 0.5% w/w CBD-C4.

9. The method of claim 1 , wherein the administering reduces the number of seizures compared to baseline.

10. The method of claim 1 , wherein the administering reduces total seizure frequency compared to baseline.

11. The method of claim 1 , wherein the administering reduces total seizure frequency by at least 50% compared to baseline.

12. The method of claim 8 , wherein the administering reduces the number of seizures compared to baseline.

13. The method of claim 8 , wherein the administering reduces total seizure frequency compared to baseline.

14. The method of claim 8 , wherein the administering reduces total seizure frequency by at least 50% compared to baseline.

15. The method of claim 1 , wherein the dose of CBD is about 10 mg/kg/day.

16. The method of claim 15 , wherein the administering reduces the number of seizures compared to baseline.

17. The method of claim 15 , wherein the administering reduces total seizure frequency compared to baseline.

18. The method of claim 15 , wherein the administering reduces total seizure frequency by at least 50% compared to baseline.

19. The method of claim 1 , wherein the dose of CBD is about 20 mg/kg/day.

20. The method of claim 19 , wherein the administering reduces the number of seizures compared to baseline.

21. The method of claim 19 , wherein the administering reduces total seizure frequency compared to baseline.

22. The method of claim 19 , wherein the administering reduces total seizure frequency by at least 50% compared to baseline.

23. The method of claim 1 , wherein the dose of CBD administered to the patient is about 25 mg/kg/day.

24. The method of claim 23 , wherein the administering reduces the number of seizures compared to baseline.

25. The method of claim 23 , wherein the administering reduces total seizure frequency compared to baseline.

26. The method of claim 23 , wherein the administering reduces total seizure frequency by at least 50% compared to baseline.

27. The method of claim 1 , wherein the pharmaceutical composition is an oral solution comprising the cannabidiol (CBD) drug substance.

28. The method of claim 1 , wherein the seizures comprise tonic-clonic seizures, myoclonic seizures, absence seizures, or a combination thereof.

29. The method of claim 1 , wherein the CBD drug substance comprises synthetic CBD.

Assignments (4)
SECURITY AGREEMENT Recorded Apr 21, 2026
From: CAVION, INC.; JAZZ PHARMACEUTICALS, INC.; JAZZ PHARMACEUTICALS IRELAND LIMITED; JAZZ PHARMACEUTICALS RESEARCH UK LIMITED; JAZZ PHARMACEUTICALS THERAPEUTICS, INC.
To: U.S. BANK TRUST COMPANY, NATIONAL ASSOCIATION, AS COLLATERAL TRUSTEE
Reel/Frame 075442/0203 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 14, 2025
From: GUY, GEOFFREY; WRIGHT, STEPHEN; DEVINSKY, ORRIN
To: GW PHARMA LIMITED
Reel/Frame 072026/0146 →
CHANGE OF NAME Recorded Aug 14, 2025
From: GW RESEARCH LIMITED
To: JAZZ PHARMACEUTICALS RESEARCH UK LIMITED
Reel/Frame 072027/0144 →
ASSET PURCHASE BY WAY OF DEED Recorded Aug 14, 2025
From: GW PHARMA LIMITED
To: GW RESEARCH LIMITED
Reel/Frame 072464/0012 →
Priority Claims (1)
GB 1418171 · Oct 14, 2014 · national
Continuity (10)
Continuation 18186792 · Mar 20, 2023
Continuation 17819046 · Aug 11, 2022
Continuation 17477172 · Sep 16, 2021
Continuation 17242075 · Apr 27, 2021
Continuation 17198965 · Mar 11, 2021
Continuation 16911914 · Jun 25, 2020
Continuation 16198141 · Nov 21, 2018
Continuation 15449535 · Mar 3, 2017
Continuation 14881969 · Oct 13, 2015
Related Publication 20250248950A1 · Aug 7, 2025
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