IP Library Granted Patent US 12,661,368
Granted Patent B2
US 12,661,368 · App. 19/347,325 · Granted Jun 23, 2026

Maribavir isomers, compositions, methods of making and methods of using

Inventor: John D. Peabody, III (West Chester, PA)
Assignee: Takeda Pharmaceutical Company Limited
A61K31/7056A61K45/06G01N33/94G09B19/00G01N2430/00G01N2800/52
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Quick Facts
Patent No.
US 12,661,368
App. No.
19/347,325
Granted
Jun 23, 2026
Kind
B2
Abstract

The invention relates to novel compositions and methods of using maribavir which enhance its effectiveness in medical therapy, as well as to maribavir isomers and methods of use thereof for counteracting the potentially adverse effects of maribavir isomerization in vivo in the event it occurs.

Claims (2)

1 . A method of treating a cytomegalovirus (CMV) infection in a patient having a CMV infection, the method comprising orally administering to the patient the compound 5,6-dichloro-2-(isopropylamino)-1-(β-L-ribofuranosyl)-1H-benzimidazole in an amount of 400 mg twice a day, wherein said compound is administered as a composition comprising a therapeutically acceptable adjuvant, excipient, or carrier medium, wherein said composition is an immediate release formulation, and wherein the immediate release formulation releases said compound from said formulation by dissolution in less than 60 minutes.

2 . A method of treating a cytomegalovirus (CMV) infection in a patient having a CMV infection, the method comprising orally administering to the patient the compound 5,6-dichloro-2-(isopropylamino)-1-(β-L-ribofuranosyl)-1H-benzimidazole in an amount of 400 mg twice a day, wherein said compound is administered as a composition comprising a therapeutically acceptable adjuvant, excipient, or carrier medium, wherein said composition is an immediate release formulation, and wherein the immediate release formulation releases said compound from said formulation in vivo in less than 60 minutes following administration.

Assignments (4)
CHANGE OF NAME Recorded Mar 12, 2026
From: VIROPHARMA INCORPORATED
To: SHIRE VIROPHARMA INCORPORATED
Reel/Frame 074914/0444 →
CHANGE OF NAME Recorded Mar 12, 2026
From: SHIRE VIROPHARMA INCORPORATED
To: SHIRE VIROPHARMA LLC
Reel/Frame 074914/0581 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 12, 2026
From: PEABODY, JOHN D., III
To: VIROPHARMA INCORPORATED
Reel/Frame 074051/0172 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 12, 2026
From: SHIRE VIROPHARMA LLC
To: TAKEDA PHARMACEUTICAL COMPANY LIMITED
Reel/Frame 074051/0178 →
Continuity (11)
Continuation 18828652 · Sep 9, 2024
Continuation 18597197 · Mar 6, 2024
Continuation 18200636 · May 23, 2023
Division 16983310 · Aug 3, 2020
Division 16663743 · Oct 25, 2019
Division 15291639 · Oct 12, 2016
Division 15055043 · Feb 26, 2016
Continuation 14595548 · Jan 13, 2015
Continuation 13282501 · Oct 27, 2011
Provisional Application 61407637 · Oct 28, 2010
Related Publication 20260021129A1 · Jan 22, 2026
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