Selective androgen receptor modulators and methods of use thereof
View Patent ↗This invention provides a class of androgen receptor targeting agents. The agents define a new subclass of compounds, which are selective androgen receptor modulators (SARM).
1. A selective androgen receptor modulator (SARM) compound represented by the structure of formula (IV):
wherein X is O; and
Y is a lipid soluble group, wherein said lipid soluble group is selected from CH 2 CH 3 , CH 2 CH 2 CH 3 , CH 2 CH 2 CH 2 CH 3 , (CH 2 ) n CH 3 wherein n≧4, or C 6 H 5 ;
or its isomer, metabolite, pharmaceutically acceptable salt, pharmaceutical product, crystal, N-oxide or any combination thereof.
2. A composition comprising the selective androgen receptor modulator compound of claim 1 , and/or its isomer, metabolite, pharmaceutically acceptable salt, pharmaceutical product, crystal, N-oxide or any combination thereof; and a suitable carrier or diluent.
3. A pharmaceutical composition comprising an effective amount of the selective androgen receptor modulator compound of claim 1 , and/or its isomer, metabolite, pharmaceutically acceptable salt, pharmaceutical product, crystal, N oxide; and a pharmaceutically acceptable carrier, diluent or salt.