IP Library Granted Patent US 10,010,567
Granted Patent B2
US 10,010,567 · App. 15/589,605 · Granted Jul 3, 2018

Bioeffective krill oil compositions

Inventors: Inge Bruheim (Volda, NO); Snorre Tilseth (Bergen, NO); Daniele Mancinelli (Orsta, NO)
Assignee: AKER BIOMARINE ANTARCTIC AS
A61K35/612A23L33/115A61K9/0053A61K9/48A61K9/4825A61K31/202A61K31/215A61K31/575A61K31/685A23V2002/00
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Quick Facts
Patent No.
US 10,010,567
App. No.
15/589,605
Granted
Jul 3, 2018
Kind
B2
Abstract

This disclosure discloses new krill oil compositions characterized by having high amounts of phospholipids, astaxanthin esters and/or omega-3 contents. The krill oils are obtained from krill meal using supercritical fluid extraction in a two stage process. Stage 1 removes the neutral lipid by extracting with neat supercritical CO 2 or CO 2 plus approximately 5% of a co-solvent. Stage 2 extracts the actual krill oils by using supercritical CO 2 in combination with approximately 20% ethanol. The krill oil materials obtained are compared with commercially available krill oil and found to be more bioeffective in a number of areas such as anti-inflammation, anti-oxidant effects, improving insulin resistances and improving blood lipid profile.

Claims (20)

1. Encapsulated krill oil comprising a capsule containing Euphausia superba krill oil suitable for oral administration, said krill oil comprising greater than 30% phosphatidylcholine w/w of said krill oil, less than 3% free fatty acids w/w of said krill oil and astaxanthin esters.

2. Encapsulated krill oil of claim 1 , wherein said krill oil comprises greater than 40% phosphatidylcholine w/w of said krill oil.

3. Encapsulated krill oil of claim 1 , wherein said krill oil comprises greater than 45% phosphatidylcholine w/w of said krill oil.

4. Encapsulated krill oil of claim 1 , wherein said capsule contains a phytonutrient derived from a source other than krill.

5. Encapsulated krill oil of claim 1 , wherein said krill oil further comprises from 20% to 50% w/w triglycerides.

6. Encapsulated krill oil of claim 5 , wherein said krill oil further comprises at least 20% omega-3 fatty acids as a percentage of total fatty acids in said composition.

7. Encapsulated krill oil of claim 1 , wherein said capsule is a soft gel capsule.

8. Encapsulated krill oil of claim 1 , wherein said krill oil comprises less than about 3% lysophosphatidylcholine w/w of said krill oil.

9. Encapsulated krill oil of claim 1 , wherein said krill oil comprises less than about 2% lysophosphatidylcholine w/w of said krill oil.

10. Encapsulated krill oil of claim 1 , wherein said astaxanthin esters are present in the krill oil at in an amount of at least 100 mg/kg.

11. Encapsulated krill oil of claim 1 , wherein said astaxanthin esters are present in the krill oil at in an amount of at least 200 mg/kg.

12. Encapsulated krill oil of claim 1 , wherein said krill oil comprises less than about 0.45% arachidonic acid w/w of said krill oil, wherein w/w is the weight percent of arachidonic acid as a percent of total fatty acids.

13. Encapsulated krill oil of claim 1 , wherein said krill oil comprises less than about 0.5 g/100 g total cholesterol.

14. Encapsulated krill oil of claim 1 , wherein said krill oil comprises at least 36% w/w omega-3 fatty acids, wherein w/w is the weight percent of omega-3 fatty acids as a percent of total fatty acids.

15. Encapsulated krill oil comprising a soft gel capsule containing Euphausia superba krill oil suitable for oral administration, said krill oil comprising greater than 30% phosphatidylcholine w/w of said krill oil, less than 3% free fatty acids w/w of said krill oil, less than about 3% lysophosphatidylcholine w/w of said krill oil and at least 100 mg/kg astaxanthin esters.

16. Encapsulated krill oil of claim 15 , wherein said krill oil comprises greater than 40% phosphatidylcholine w/w of said krill oil.

17. Encapsulated krill oil of claim 15 , wherein said astaxanthin esters are present in the krill oil at in an amount of at least 200 mg/kg.

18. Encapsulated krill oil of claim 15 , wherein said krill oil comprises less than about 0.45% w/w arachidonic acid, wherein w/w is the weight percent of arachidonic acid as a percent of total fatty acids.

19. Encapsulated krill oil of claim 15 , wherein said krill oil comprises less than about 0.5 g/100 g total cholesterol.

20. Encapsulated krill oil of claim 15 , wherein said krill oil comprises at least 36% w/w omega-3 fatty acids, wherein w/w is the weight percent of omega-3 fatty acids as a percent of total fatty acids.

Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 8, 2024
From: AKER BIOMARINE ANTARCTIC AS
To: AKER BIOMARINE HUMAN INGREDIENTS AS
Reel/Frame 066703/0864 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 26, 2017
From: AKER BIOMARINE AS
To: AKER BIOMARINE ANTARCTIC AS
Reel/Frame 043099/0443 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 25, 2017
From: BRUHEIM, INGE; TILSETH, SNORRE; MANCINELLI, DANIELE
To: AKER BIOMARINE AS
Reel/Frame 043087/0315 →
Continuity (8)
Continuation 15180439 · Jun 13, 2016
Continuation 14020162 · Sep 6, 2013
Continuation 12057775 · Mar 28, 2008
Provisional Application 60920483 · Mar 28, 2007
Provisional Application 60975058 · Sep 25, 2007
Provisional Application 60983446 · Oct 29, 2007
Provisional Application 61024072 · Jan 28, 2008
Related Publication 20170246219A1 · Aug 31, 2017