Treatment and diagnosis of inflammatory disorders and HIV
This invention concerns compositions and methods of treating or diagnosing inflammatory disorders and other disorders, as well as compositions and methods of treating HIV.
1. A method of treating an inflammatory autoimmune disease characterized by an influx of immune cells into the central nervous system, the method consisting essentially of administering to a subject in need thereof, a therapeutically effective amount of a leukotoxin comprising SEQ ID NO: 1, wherein the inflammatory autoimmune disease is multiple sclerosis which is characterized by upregulated expression of leukocyte function antigen-1 (LFA-1) on the surface of activated immune cells from blood and cerebrospinal fluid of the subject, wherein the leukotoxin depletes and/or blocks the activated immune cells in the central nervous system of the subject.
2. The method of claim 1 , wherein the leukotoxin is prepared from Aggregatibacter actinomycetemcomitans.
3. A method of treating an inflammatory autoimmune disease characterized by an influx of immune cells into the central nervous system, the method consisting of administering to a subject in need thereof a therapeutically effective amount of a leukotoxin comprising SEQ ID NO: 1, wherein the inflammatory autoimmune disease is multiple sclerosis which is characterized by upregulated expression of leukocyte function antigen-1 (LFA-1) on the surface of activated immune cells from blood and cerebrospinal fluid of the subject, wherein the leukotoxin depletes and/or blocks the activated immune cells in the central nervous system of the subject.
4. The method of claim 2 , wherein the leukotoxin is prepared from Aggregatibacter actinomycetemcomitans.