IP Library › Granted Patent US 10,383,938
Granted Patent B2
US 10,383,938 · App. 16/043,394 · Granted Aug 20, 2019

Lipidated immune response modifier compound compositions, formulations, and methods

Inventor: Paul D. Wightman (St. Paul, MN)
Assignee: 3M Innovative Properties Company
A61K39/39A61K9/0019A61K9/10A61K9/127A61K31/437A61K31/47A61K39/0011A61K39/145A61K47/26C07D471/04C12N7/00A61K2039/54A61K2039/55511A61K2039/55555A61K2039/55572A61K2039/572C12N2760/16134Y02A50/41Y02A50/412
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Quick Facts
Patent No.
US 10,383,938
App. No.
16/043,394
Granted
Aug 20, 2019
Kind
B2
Abstract

The compound N-(4-{[4-amino-2-butyl-1H-imidazo[4,5-c]quinolin-1-yl]oxy}butyl)octadecanamide is a useful drug compound for enhancing immune response and can be used, for example, as a vaccine adjuvant and a cancer treatment.

Claims (12)

1. A method of treating a viral, bacterial, fungal, or parasitic infection in an animal comprising administering an effective amount of a compound having the formula N-(4-{[4-amino-2-butyl-1H-imidazo[4,5-c]quinolin-1-yl]oxy}butyl)octadecanamide, or a pharmaceutically acceptable salt thereof, to the animal.

2. The method of claim 1 , which treats a viral infection in an animal.

3. The method of claim 1 , which treats a bacterial infection in an animal.

4. The method of claim 1 , which treats a fungal infection in an animal.

5. The method of claim 1 , which treats a parasitic infection in an animal.

6. The method of claim 1 , wherein the compound is co-delivered with a vaccine.

7. The method of claim 1 , wherein the treatment is a therapeutic or prophylactic treatment.

8. The method of claim 1 , wherein the treatment is a therapeutic treatment.

9. The method of claim 1 , wherein the treatment is a prophylactic treatment.

10. The method of claim 1 , wherein an antigen is co-delivered with the compound.

11. The method of claim 10 , wherein the antigen is a vaccine.

12. The method of claim 10 , wherein the antigen is co-delivered with the compound as an admixture in a pharmaceutical composition.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 1, 2024
From: 3M INNOVATIVE PROPERTIES COMPANY
To: SOLVENTUM INTELLECTUAL PROPERTIES COMPANY
Reel/Frame 066430/0295 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 24, 2018
From: WIGHTMAN, PAUL D.
To: 3M INNOVATIVE PROPERTIES COMPANY
Reel/Frame 046439/0861 →
Continuity (6)
Continuation 15822556 · Nov 27, 2017
Continuation 15241166 · Aug 19, 2016
Continuation 14969483 · Dec 15, 2015
Division 13817214
Provisional Application 61374512 · Aug 17, 2010
Related Publication 20180326051A1 · Nov 15, 2018