IP Library › Granted Patent US 10,472,375
Granted Patent B2
US 10,472,375 · App. 16/298,460 · Granted Nov 12, 2019

5,6-dihydro-4H-benzo[b]thieno-[2,3-d]azepine derivative

Inventors: Simon Fraser Hunt (Nottingham, GB); Stuart Thomas Onions (Nottingham, GB); Vladimir Sherbukhin (Nottingham, GB); Euan Alexander Fraser Fordyce (Nottingham, GB); Peter John Murray (London, GB); Daniel William Brookes (London, GB); Kazuhiro Ito (London, GB); Peter Strong (London, GB); Matthew Stephen Coates (London, GB)
Assignee: PULMOCIDE LIMITED
C07D519/00A61K9/10A61K9/14A61K31/55A61K45/06C07D495/04
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Quick Facts
Patent No.
US 10,472,375
App. No.
16/298,460
Granted
Nov 12, 2019
Kind
B2
Abstract

There is provided a 5,6-dihydro-4H-benzo[b]thieno-[2,3-d]azepine derivative which is useful in the treatment of respiratory syncytial virus (RSV) infection and for the prevention of disease associated with RSV infection. (Formula (I)).

Claims (18)

1. A process for the preparation of a compound of formula (IV):

or a salt thereof;

which comprises reacting a compound of formula (VII):

or a salt thereof;

with 2-fluoro-6-methylaniline

or a salt thereof;

followed by reduction of the nitro group.

2. The process of claim 1 wherein the reduction is a dissolving metal reduction.

3. The process of claim 1 wherein the reduction is a catalytic hydrogenation reaction.

4. A process for the preparation of a compound of formula (X):

or a salt thereof;

which comprises reacting a compound of formula (IX):

wherein R a is lower alkyl;

or a salt thereof;

with a compound of formula (V):

or a salt thereof.

5. The process of claim 4 wherein R a is C 1-6 alkyl.

6. The process of claim 5 wherein the C 1-6 alkyl group is ethyl.

Priority Claims (1)
EP 14188494 · Oct 10, 2014 · regional
Continuity (5)
Continuation 16033464 · Jul 12, 2018
Continuation 15902077 · Feb 22, 2018
Continuation 15642637 · Jul 6, 2017
Continuation 15305003
Related Publication 20190202841A1 · Jul 4, 2019