5,6-dihydro-4H-benzo[b]thieno-[2,3-d]azepine derivative
There is provided a 5,6-dihydro-4H-benzo[b]thieno-[2,3-d]azepine derivative which is useful in the treatment of respiratory syncytial virus (RSV) infection and for the prevention of disease associated with RSV infection. (Formula (I)).
1. A process for the preparation of a compound of formula (IV):
or a salt thereof;
which comprises reacting a compound of formula (VII):
or a salt thereof;
with 2-fluoro-6-methylaniline
or a salt thereof;
followed by reduction of the nitro group.
2. The process of claim 1 wherein the reduction is a dissolving metal reduction.
3. The process of claim 1 wherein the reduction is a catalytic hydrogenation reaction.
4. A process for the preparation of a compound of formula (X):
or a salt thereof;
which comprises reacting a compound of formula (IX):
wherein R a is lower alkyl;
or a salt thereof;
with a compound of formula (V):
or a salt thereof.
5. The process of claim 4 wherein R a is C 1-6 alkyl.
6. The process of claim 5 wherein the C 1-6 alkyl group is ethyl.