IP Library Granted Patent US 11,225,641
Granted Patent B2
US 11,225,641 · App. 16/789,768 · Granted Jan 18, 2022

Probiotic

Inventors: Liam O'Mahony (Cork, IE); Barry Kiely (Cork, IE); John Francis Cryan (Cork, IE); Timothy Dinan (Cork, IE); Eileen Frances Murphy (Cork, IE)
Assignee: PrecisionBiotics Group Limited
C12N1/205A23C9/1234A23G9/363A23L33/135A61K35/745C12N1/20A23V2002/00A23Y2300/55C12R2001/01Y02A50/30
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Quick Facts
Patent No.
US 11,225,641
App. No.
16/789,768
Granted
Jan 18, 2022
Kind
B2
Abstract

Probiotic Bifidobacterium strain AH1714 is significantly immunomodulatory following oral consumption. The strain is useful as an immunomodulatory biotherapeutic agent.

Claims (21)

1. A method for treating a subject, the method comprising administering to the subject an oral formulation comprising isolated strain Bifidobacterium longum deposited with NCIMB under accession number NCIMB 41676, wherein the Bifidobacterium longum strain is in the form of a powder,

wherein the subject has a disorder chosen from an anxiety disorder, a mood disorder, or a behavioral disorder, and the formulation treats the disorder.

2. The method of claim 1 , wherein the formulation reduces stress of the subject.

3. The method of claim 1 , wherein the disorder is bipolar illness, depression, obsessive compulsive disorder, panic disorder, generalized anxiety disorder, or post-traumatic disorder.

4. The method of claim 1 , wherein the subject is a human.

5. The method of claim 1 , wherein administration of the formulation is part of a regimen for replacing a selective serotonin reuptake inhibitor.

6. The method of claim 5 , wherein the selective serotonin reuptake inhibitor is escitalopram.

7. The method of claim 1 , wherein the formulation comprises an ingestible carrier.

8. The method of claim 7 , wherein the ingestible carrier comprises a dairy product.

9. The method of claim 7 , wherein the ingestible carrier comprises a dressing or a beverage.

10. The method of claim 1 , wherein the composition comprises more than 10 6 cfu of the Bifidobacterium longum strain per gram of the composition.

11. A method for treating a subject, the method comprising administering to the subject an oral formulation comprising isolated strain Bifidobacterium longum deposited with NCIMB under accession number NCIMB 41676 and an ingestible carrier,

wherein the subject has a disorder chosen from an anxiety disorder, a mood disorder, or a behavioral disorder, and the formulation treats the disorder.

12. The method of claim 11 , wherein each of the Bifidobacterium longum strain and the ingestible carrier is in the form of a powder, the formulation being administered in the form of a powder.

13. The method of claim 11 , wherein the formulation comprises more than 10 6 cfu of the Bifidobacterium longum strain per gram of the formulation.

14. The method of claim 11 , wherein the formulation is administered in the form of a food product or a beverage.

15. The method of claim 11 , wherein the formulation is administered in the form of a capsule or a tablet.

16. A method for treating a subject, the method comprising administering to the subject an oral formulation comprising isolated strain Bifidobacterium longum deposited with NCIMB under accession number NCIMB 41676 and an ingestible carrier, wherein the Bifidobacterium longum strain is in the form of a powder, wherein the formulation comprises more than 10 6 cfu per gram of the Bifidobacterium longum strain;

wherein the subject has a disorder chosen from an anxiety disorder, a mood disorder, or a behavioral disorder, and the formulation treats the disorder.

17. The method of claim 16 , wherein the formulation is administered in the form of a food product or a beverage.

18. The method of claim 16 , wherein the formulation reduces stress of the subject.

Assignments (7)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 21, 2020
From: O'MAHONY, LIAM; KIELY, BARRY; MURPHY, EILEEN FRANCES
To: ALIMENTARY HEALTH LIMITED
Reel/Frame 051889/0356 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 21, 2020
From: ALIMENTARY HEALTH LIMITED
To: THE PROCTER & GAMBLE COMPANY
Reel/Frame 051889/0378 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 21, 2020
From: THE PROCTER & GAMBLE COMPANY
To: ALIMENTARY HEALTH LIMITED
Reel/Frame 051890/0425 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 21, 2020
From: CRYAN, JOHN F.
To: UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK
Reel/Frame 051991/0491 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 21, 2020
From: DINAN, TIMOTHY G.
To: UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK
Reel/Frame 051991/0534 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 21, 2020
From: UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK
To: ALIMENTARY HEALTH LIMITED
Reel/Frame 051991/0697 →
CHANGE OF NAME Recorded Feb 21, 2020
From: ALIMENTARY HEALTH LIMITED
To: PRECISIONBIOTICS GROUP LIMITED
Reel/Frame 051992/0098 →
Continuity (6)
Continuation 15936661 · Mar 27, 2018
Continuation 13468374 · May 10, 2012
Continuation PCTIE2010000066 · Nov 11, 2010
Continuation In Part 12616752 · Nov 11, 2009
Provisional Application 61344030 · May 11, 2010
Related Publication 20200325548A1 · Oct 15, 2020
Cited By (1)
US 12,419,920