IP Library › Granted Patent US 12,419,920
Granted Patent B2
US 12,419,920 · App. 18/455,329 · Granted Sep 23, 2025

Patent

Inventors: Eileen Frances Murphy (Cork, IE); Paul Enck (Berlin, DE); Christoph Braun (Tuebingen, DE); Huiying Wang (Shanghai, CN)
Assignee: PrecisionBiotics Group Limited
A61K35/745A23L33/135A23L33/21A61K39/39A61K9/0053A61K9/14A61K9/20A61K9/48
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Quick Facts
Patent No.
US 12,419,920
App. No.
18/455,329
Granted
Sep 23, 2025
Kind
B2
Abstract

Bifidobacterium longum strain NCIMB 41676 is useful for improving or sustaining vitality and/or reducing mental fatigue in stressful situations.

Claims (20)

1. A method of treating a subject, the method comprising administering to the subject a formulation comprising Bifidobacterium longum strain having the accession number NCIMB 41676 and a carrier, wherein the formulation reduces mental fatigue in the subject as measured by an increase in theta band resting state brain oscillations in the frontal and cingulate cortex or a decrease in beta-3 resting state brain oscillations in the hippocampus, fusiform, and temporal cortex.

2. The method of claim 1 , wherein the formulation is administered daily.

3. The method of claim 1 , wherein the formulation increases energy in the subject.

4. The method of claim 1 , wherein the formulation improves vitality in the subject.

5. The method of claim 1 , wherein the subject is a human.

6. The method of claim 5 , wherein the subject is at least 60 years old.

7. The method of claim 5 , wherein the formulation is an infant food.

8. The method of claim 1 , wherein the formulation is in the form of a capsule, a tablet or a powder.

9. The method of claim 1 , wherein the carrier is a food product chosen from acidified milk, a yoghurt, a frozen food a gum, a candy, a milk powder, a milk concentrate, a cheese spread, a nutritional composition, a nutritional supplement, a cereal bar, a dressing, or a beverage.

10. The method of claim 1 , wherein the formulation further comprises a protein, a peptide, or both a protein and a peptide.

11. The method of claim 1 , wherein the strain is present in an amount from 10 6 cfu to 10 10 cfu.

12. A method of treating a human subject, the method comprising administering to the subject a formulation Bifidobacterium longum strain having the accession number NCIMB 41676 and an ingestible carrier, wherein the formulation improves or sustains vitality in the subject as measured by neural activity, the 36-item short-form health survey (SF36), or both.

13. The method of claim 12 , wherein the neural activity includes an increase in theta band resting state brain oscillations of the cingulate cortex or a decrease in beta-3 resting state brain oscillations in the hippocampus, fusiform, or temporal cortex.

14. The method of claim 12 , wherein the formulation reduces mental fatigue in the subject.

15. The method of claim 12 , wherein the formulation is in the form of a capsule, a tablet, or a powder.

16. The method of claim 12 , wherein the ingestible carrier is a food product chosen from acidified milk, a yoghurt, a frozen food, a gum, a candy, a milk powder, a milk concentrate, a cheese spread, a nutritional composition, a nutritional supplement, a cereal bar, a dressing, or a beverage.

17. The method of claim 12 , wherein the formulation is an infant food.

18. The method of claim 12 , wherein the formulation further comprises a protein, a peptide, a lipid, a carbohydrate, a vitamin, a mineral, a trace element, or a combination thereof.

19. The method of claim 12 , wherein the strain is present in an amount from 10 6 cfu to 10 10 cfu.

20. The method of claim 12 , wherein the formulation is administered daily.

Assignments (6)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 1, 2025
From: MURPHY, EILEEN FRANCES
To: ALIMENTARY HEALTH LIMITED
Reel/Frame 070694/0241 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 1, 2025
From: ENCK, PAUL; BRAUN, CHRISTOPH
To: UNIVERSITATSKLINIKUM TUEBINGEN
Reel/Frame 070694/0297 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 1, 2025
From: UNIVERSITATSKLINIKUM TUEBINGEN
To: UNIVERSITATSKLINIKUM TUEBINGEN, FOR THE EBERHARD KARLS UNIVERSITAET TUEBINGEN MEDIZINISCHE FAKULTAET
Reel/Frame 070694/0409 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 1, 2025
From: UNIVERSITATSKLINIKUM TUEBINGEN, FOR THE EBERHARD KARLS UNIVERSITAET TUEBINGEN MEDIZINISCHE FAKULTAET
To: ALIMENTARY HEALTH LIMITED
Reel/Frame 070694/0478 →
CHANGE OF NAME Recorded Apr 1, 2025
From: ALIMENTARY HEALTH LIMITED
To: PRECISIONBIOTICS GROUP LIMITED
Reel/Frame 070694/0652 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 1, 2025
From: WANG, HUIYING
To: PRECISIONBIOTICS GROUP LIMITED
Reel/Frame 070694/0733 →
Priority Claims (1)
EP 18153993 · Jan 29, 2018 · regional
Continuity (2)
Continuation 16767874
Related Publication 20230414681A1 · Dec 28, 2023
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