IP Library › Granted Patent US 11,998,576
Granted Patent B2
US 11,998,576 · App. 17/403,284 · Granted Jun 4, 2024

Direct-fed microbials

Inventors: Michael R. King (Oak Creek, WI); Sona Son (Cudahy, WI); Kyle Leistikow (Franklin, WI); Nathan Robert Augspurger (Noblesville, IN)
Assignees: MICROBIAL DISCOVERY GROUP, LLC; UNITED ANIMAL HEALTH, INC.
A61K35/742A23K10/18A23K20/10A23K20/195A23K50/30A23K50/75A61K35/74A61K38/43A61K45/06
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Quick Facts
Patent No.
US 11,998,576
App. No.
17/403,284
Granted
Jun 4, 2024
Kind
B2
Abstract

The invention relates to direct-fed microbials for use in E. coli inhibition in animals. More particularly, the invention relates to isolated Bacillus strains 101, 235, 77, 177, and 102 and strains having all of the identifying characteristics of these strains, for a use comprising the above-mentioned use. The invention can also be used for treatment of plants and in food processing.

Claims (16)

1. A nutrient composition comprising an isolated Bacillus strain selected from the group consisting of Bacillus strain 101 (NRRL No. B-67218), Bacillus strain 235 (NRRL No. B-67219), Bacillus strain 77 (NRRL No. B-67274), Bacillus strain 177 (NRRL No. B-67275), Bacillus strain 102 (NRRL No. B-67276), a strain having all of the identifying characteristics of Bacillus strain 101 (NRRL No. B-67218), a strain having all of the identifying characteristics of Bacillus strain 235 (NRRL No. B-67219), a strain having all of the identifying characteristics of Bacillus strain 77 (NRRL No. B-67274), a strain having all of the identifying characteristics of Bacillus strain 177 (NRRL No. B-67275), a strain having all of the identifying characteristics of Bacillus strain 102 (NRRL No. B-67276), and combinations thereof, wherein the composition further comprises a carrier and the composition causes E. coli inhibition in an animal.

2. The composition of claim 1 wherein the carrier is selected from the group consisting of a bran, rice hulls, a salt, mineral oil, a dextrin, whey, sugar, limestone, dried starch, sodium silico aluminate, vegetable oil, and combinations thereof.

3. The composition of claim 1 wherein the composition further comprises an exogenously added nutrient component selected from the group consisting of a vitamin, an antibiotic, an enzyme, a water-soluble or water-insoluble monosaccharide, disaccharide, or polysaccharide, a fat, phosphorous, sodium bicarbonate, limestone, calcium, sodium, sulfur, magnesium, potassium, copper, iron, manganese, zinc, fish oil, raw seed, an antioxidant, and a starch.

4. The composition of claim 1 further comprising a binder wherein the binder is selected from the group consisting of clay, yeast cell wall components, aluminum silicate, glucan, and combinations thereof.

5. The composition of claim 1 in the form of a commercial package.

6. The composition of claim 5 wherein the commercial package comprises a container selected from the group consisting of a bag, a pouch, a drum, a bottle, and a box.

7. The composition of claim 3 wherein the exogenously added component is an enzyme.

8. The composition of claim 7 wherein the enzyme is selected from the group consisting of a galactosidase, a protease, a lipase, an amylase, a hemicellulase, an arabinoxylanase, a xylanase, a cellulase, an NSPase, a phytase, and combinations thereof.

9. The composition of claim 1 wherein the isolated Bacillus strain is selected from the group consisting of Bacillus strain 101 (NRRL No. B-67218), Bacillus strain 235 (NRRL No. B-67219), Bacillus strain 77 (NRRL No. B-67274), Bacillus strain 177 (NRRL No. B-67275), and Bacillus strain 102 (NRRL No. B-67276), and combinations thereof.

10. The composition of claim 2 wherein the isolated Bacillus strain is selected from the group consisting of Bacillus strain 101 (NRRL No. B-67218), Bacillus strain 235 (NRRL No. B-67219), Bacillus strain 77 (NRRL No. B-67274), Bacillus strain 177 (NRRL No. B-67275), and Bacillus strain 102 (NRRL No. B-67276), and combinations thereof.

11. The composition of claim 3 wherein the isolated Bacillus strain is selected from the group consisting of Bacillus strain 101 (NRRL No. B-67218), Bacillus strain 235 (NRRL No. B-67219), Bacillus strain 77 (NRRL No. B-67274), Bacillus strain 177 (NRRL No. B-67275), and Bacillus strain 102 (NRRL No. B-67276), and combinations thereof.

12. The composition of claim 4 wherein the isolated Bacillus strain is selected from the group consisting of Bacillus strain 101 (NRRL No. B-67218), Bacillus strain 235 (NRRL No. B-67219), Bacillus strain 77 (NRRL No. B-67274), Bacillus strain 177 (NRRL No. B-67275), and Bacillus strain 102 (NRRL No. B-67276), and combinations thereof.

13. The composition of claim 5 wherein the isolated Bacillus strain is selected from the group consisting of Bacillus strain 101 (NRRL No. B-67218), Bacillus strain 235 (NRRL No. B-67219), Bacillus strain 77 (NRRL No. B-67274), Bacillus strain 177 (NRRL No. B-67275), and Bacillus strain 102 (NRRL No. B-67276), and combinations thereof.

14. The composition of claim 6 wherein the isolated Bacillus strain is selected from the group consisting of Bacillus strain 101 (NRRL No. B-67218), Bacillus strain 235 (NRRL No. B-67219), Bacillus strain 77 (NRRL No. B-67274), Bacillus strain 177 (NRRL No. B-67275), and Bacillus strain 102 (NRRL No. B-67276), and combinations thereof.

15. The composition of claim 7 wherein the isolated Bacillus strain is selected from the group consisting of Bacillus strain 101 (NRRL No. B-67218), Bacillus strain 235 (NRRL No. B-67219), Bacillus strain 77 (NRRL No. B-67274), Bacillus strain 177 (NRRL No. B-67275), and Bacillus strain 102 (NRRL No. B-67276), and combinations thereof.

16. The composition of claim 8 wherein the isolated Bacillus strain is selected from the group consisting of Bacillus strain 101 (NRRL No. B-67218), Bacillus strain 235 (NRRL No. B-67219), Bacillus strain 77 (NRRL No. B-67274), Bacillus strain 177 (NRRL No. B-67275), and Bacillus strain 102 (NRRL No. B-67276), and combinations thereof.

Continuity (5)
Division 16454593 · Jun 27, 2019
Continuation 15445193 · Feb 28, 2017
Provisional Application 62364271 · Jul 19, 2016
Provisional Application 62301438 · Feb 29, 2016
Related Publication 20220241352A1 · Aug 4, 2022
Cited By (2)
US 12,369,604 US 12,514,885