Phenothiazine diaminium salts and their use
Disclosed are compounds of general formula (I): and pharmaceutically acceptable salts thereof, formulations, methods and uses in, for example, the treatment of disease.
1. A dosage unit comprising 20 to 300 mg of a compound of the following formula:
or comprising 20 to 300 mg of a free base equivalent of said compound, and further comprising a pharmaceutically acceptable carrier, diluent, or excipient.
2. The dosage unit according to claim 1 , which is a tablet comprising 20 to 300 mg of the compound.
3. The dosage unit according to claim 1 , which is a capsule comprising 20 to 300 mg of the compound.
4. The dosage unit according to claim 1 , which comprises 30 to 200 mg of the compound.
5. The dosage unit according to claim 1 , which comprises about 30 mg of the compound.
6. The dosage unit according to claim 1 , in which less than 12% of said compound is converted to methylthionium:
over 2 years when stored at 25° C. at a relative humidity of 60%.
7. The dosage unit according to claim 1 , which comprises about 60 mg of the compound.
8. The dosage unit according to claim 1 , which comprises about 100 mg of the compound.
9. The dosage unit according to claim 1 , which comprises about 150 mg of the compound.
10. The dosage unit according to claim 1 , which comprises about 200 mg of the compound.
11. The dosage unit according to claim 1 , which is a tablet comprising 20 to 300 mg of the free base equivalent of the compound.
12. The dosage unit according to claim 1 , which is a capsule comprising 20 to 300 mg of the free base equivalent of the compound.
13. The dosage unit according to claim 1 , which comprises 30 to 200 mg of the free base equivalent of the compound.
14. The dosage unit according to claim 1 , which comprises about 30 mg of the free base equivalent of the compound.
15. The dosage unit according to claim 1 , which comprises about 60 mg of the free base equivalent of the compound.
16. The dosage unit according to claim 1 , which comprises about 100 mg of the free base equivalent of the compound.
17. The dosage unit according to claim 1 , which comprises about 150 mg of the free base equivalent of the compound.
18. The dosage unit according to claim 1 , which comprises about 200 mg of the free base equivalent of the compound.