Granted Patent B2

US 12,186,514 · App. 17/974,212 · Granted Jan 7, 2025

Inventors: Richard J. Paolini, Jr. (Framingham, MA); Stephen J. Telfer (Arlington, MA); Timothy J. O'Malley (Westford, MA); Brian D. Bean (Newton, MA)

Assignee: E Ink Corporation

A61M35/10A61M2205/0238A61M2205/82

Abstract

Claims (38)

1. An active molecule delivery system comprising:

a first substrate comprising:

a plurality of driving electrodes,

a dielectric layer covering the plurality of electrodes, and

a first hydrophobic layer coveting the dielectric layer;

a second substrate comprising:

a common electrode,

a second hydrophobic layer covering the common electrode;

a spacer separating the first and second substrates and creating a microfluidic region between the first and second substrates;

a plurality of reservoirs in fluidic communication with the plurality of driving electrodes;

a porous diffusion layer coupled to the first substrate on a side of the substrate opposed to the first hydrophobic layer;

a plurality of passages providing fluidic communication between the hydrophobic layer and the porous diffusion layer, wherein each of the plurality of reservoirs is in fluidic communication with only one passage, thereby providing an exclusive pathway of fluidic communication between each of the plurality of reservoirs and the porous diffusion layer; and

a controller operatively coupled to the driving electrodes and configured to provide a voltage gradient between at least two driving electrodes.

2. The active molecule delivery system of claim 1 , wherein each driving electrode is coupled to a thin-film-transistor.

3. The active molecule delivery system of claim 1 , wherein the driving electrodes are flexible.

4. The active molecule delivery system of claim 1 , wherein the plurality of passages include capillary tubes or wicking fibers.

5. The active molecule delivery system of claim 4 , wherein the capillary tubes or wicking fibers are coated with a hydrophobic coating.

6. The active molecule delivery system of claim 1 , wherein the porous diffusion layer comprises acrylate, methacrylate, polycarbonate, polyvinyl alcohol, cellulose, poly(N-isopropylacrylamide) (PNIPAAm), poly(lactic-co-glycolic acid) (PLGA), polyvinylidene chloride, acrylonitrile, amorphous nylon, oriented polyester, terephthalate, polyvinyl chloride, polyethylene, polybutylene, polypropylene, polyisobutylene, or polystyrene.

7. The active molecule delivery system of claim 1 , further comprising a biocompatible adhesive in contact with the porous diffusion layer.

8. A method for delivering an active molecule to the skin of a subject, comprising:

providing an active molecule delivery system including:

a first substrate comprising:

a plurality of driving electrodes;

a dielectric layer covering the plurality of electrodes, and

a first hydrophobic layer covering the dielectric layer;

a second substrate comprising:

a common electrode,

a second hydrophobic layer covering the common electrode;

a spacer separating the first and second substrates and creating a microfluidic region between the first and second substrates;

a plurality of reservoirs in fluidic communication with the plurality of driving electrodes;

a porous diffusion layer coupled to the first substrate on a side of the substrate opposed to the first hydrophobic layer;

a plurality of passages providing fluidic communication between the hydrophobic layer and the porous diffusion layer, wherein each of the plurality of reservoirs is in fluidic communication with only one passage, thereby providing an exclusive pathway of fluidic communication between each of the plurality of reservoirs and the porous diffusion layer; and

a controller operatively coupled to the driving electrodes and configured to provide a voltage gradient between at least two driving electrodes;

coupling the porous diffusion layer to skin of a subject;

moving a solution comprising an active molecule from one of the plurality of reservoirs to the porous diffusion layer; and

allowing the active molecule to pass from the porous diffusion layer to the skin of the subject.

9. The method of claim 8 , wherein the solution comprising an active molecule is held in the reservoir until the solution comprising an active molecule is required for delivery.

10. The method of claim 8 , wherein a first reservoir contains a first solution comprising the active molecule at a first concentration and a second reservoir contains a second solution comprising the active molecule at a second concentration.

Assignments (1)

Continuity (3)

References Cited (335)